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Results: 1 to 20 of 98

1.

Hepatic deletion of SIRT1 decreases hepatocyte nuclear factor 1α/farnesoid X receptor signaling and induces formation of cholesterol gallstones in mice.

Purushotham A, Xu Q, Lu J, Foley JF, Yan X, Kim DH, Kemper JK, Li X.

Mol Cell Biol. 2012 Apr;32(7):1226-36. doi: 10.1128/MCB.05988-11. Epub 2012 Jan 30.

PMID:
22290433
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Intestine-specific deletion of SIRT1 in mice impairs DCoH2-HNF-1α-FXR signaling and alters systemic bile acid homeostasis.

Kazgan N, Metukuri MR, Purushotham A, Lu J, Rao A, Lee S, Pratt-Hyatt M, Lickteig A, Csanaky IL, Zhao Y, Dawson PA, Li X.

Gastroenterology. 2014 Apr;146(4):1006-16. doi: 10.1053/j.gastro.2013.12.029. Epub 2013 Dec 31.

PMID:
24389307
[PubMed - indexed for MEDLINE]
3.

A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition.

Lee J, Padhye A, Sharma A, Song G, Miao J, Mo YY, Wang L, Kemper JK.

J Biol Chem. 2010 Apr 23;285(17):12604-11. doi: 10.1074/jbc.M109.094524. Epub 2010 Feb 25.

PMID:
20185821
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation.

Purushotham A, Schug TT, Xu Q, Surapureddi S, Guo X, Li X.

Cell Metab. 2009 Apr;9(4):327-38. doi: 10.1016/j.cmet.2009.02.006.

PMID:
19356714
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling.

García-Rodríguez JL, Barbier-Torres L, Fernández-Álvarez S, Gutiérrez-de Juan V, Monte MJ, Halilbasic E, Herranz D, Álvarez L, Aspichueta P, Marín JJ, Trauner M, Mato JM, Serrano M, Beraza N, Martínez-Chantar ML.

Hepatology. 2014 May;59(5):1972-83. doi: 10.1002/hep.26971. Epub 2014 Mar 31.

PMID:
24338587
[PubMed - indexed for MEDLINE]
6.

Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1α regulation of FXR expression.

Liu N, Meng Z, Lou G, Zhou W, Wang X, Zhang Y, Zhang L, Liu X, Yen Y, Lai L, Forman BM, Xu Z, Xu R, Huang W.

Mol Endocrinol. 2012 May;26(5):775-85. doi: 10.1210/me.2011-1383. Epub 2012 Apr 2.

PMID:
22474109
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Farnesoid X receptor, hepatocyte nuclear factors 1alpha and 3beta are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene.

Ohtsuka H, Abe T, Onogawa T, Kondo N, Sato T, Oshio H, Mizutamari H, Mikkaichi T, Oikawa M, Rikiyama T, Katayose Y, Unno M.

J Gastroenterol. 2006 Apr;41(4):369-77.

PMID:
16741617
[PubMed - indexed for MEDLINE]
8.

Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis.

Hayhurst GP, Lee YH, Lambert G, Ward JM, Gonzalez FJ.

Mol Cell Biol. 2001 Feb;21(4):1393-403.

PMID:
11158324
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

FXR an emerging therapeutic target for the treatment of atherosclerosis.

Mencarelli A, Fiorucci S.

J Cell Mol Med. 2010 Jan;14(1-2):79-92. doi: 10.1111/j.1582-4934.2009.00997.x. Review.

PMID:
20041971
[PubMed - indexed for MEDLINE]
10.

Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity.

Guo GL, Lambert G, Negishi M, Ward JM, Brewer HB Jr, Kliewer SA, Gonzalez FJ, Sinal CJ.

J Biol Chem. 2003 Nov 14;278(46):45062-71. Epub 2003 Aug 15.

PMID:
12923173
[PubMed - indexed for MEDLINE]
Free Article
11.

Activation of the farnesoid X receptor induces hepatic expression and secretion of fibroblast growth factor 21.

Cyphert HA, Ge X, Kohan AB, Salati LM, Zhang Y, Hillgartner FB.

J Biol Chem. 2012 Jul 20;287(30):25123-38. doi: 10.1074/jbc.M112.375907. Epub 2012 Jun 1.

PMID:
22661717
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression.

Claudel T, Inoue Y, Barbier O, Duran-Sandoval D, Kosykh V, Fruchart J, Fruchart JC, Gonzalez FJ, Staels B.

Gastroenterology. 2003 Aug;125(2):544-55.

PMID:
12891557
[PubMed - indexed for MEDLINE]
13.

Role of nuclear receptors and hepatocyte-enriched transcription factors for Ntcp repression in biliary obstruction in mouse liver.

Zollner G, Wagner M, Fickert P, Geier A, Fuchsbichler A, Silbert D, Gumhold J, Zatloukal K, Kaser A, Tilg H, Denk H, Trauner M.

Am J Physiol Gastrointest Liver Physiol. 2005 Nov;289(5):G798-805. Epub 2005 Jul 7.

PMID:
16002565
[PubMed - indexed for MEDLINE]
Free Article
14.

Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.

Yin H, Hu M, Liang X, Ajmo JM, Li X, Bataller R, Odena G, Stevens SM Jr, You M.

Gastroenterology. 2014 Mar;146(3):801-11. doi: 10.1053/j.gastro.2013.11.008. Epub 2013 Nov 18.

PMID:
24262277
[PubMed - indexed for MEDLINE]
15.

Energy sensing factors PGC-1α and SIRT1 modulate PXR expression and function.

Buler M, Aatsinki SM, Skoumal R, Hakkola J.

Biochem Pharmacol. 2011 Dec 15;82(12):2008-15. doi: 10.1016/j.bcp.2011.09.006. Epub 2011 Sep 16.

PMID:
21933665
[PubMed - indexed for MEDLINE]
16.

The G protein-coupled receptor G2A: involvement in hepatic lipid metabolism and gallstone formation in mice.

Johnson LE, Elias MS, Bolick DT, Skaflen MD, Green RM, Hedrick CC.

Hepatology. 2008 Oct;48(4):1138-48. doi: 10.1002/hep.22433.

PMID:
18821587
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

SIRT1 deacetylates and positively regulates the nuclear receptor LXR.

Li X, Zhang S, Blander G, Tse JG, Krieger M, Guarente L.

Mol Cell. 2007 Oct 12;28(1):91-106.

PMID:
17936707
[PubMed - indexed for MEDLINE]
Free Article
18.

FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states.

Kemper JK, Xiao Z, Ponugoti B, Miao J, Fang S, Kanamaluru D, Tsang S, Wu SY, Chiang CM, Veenstra TD.

Cell Metab. 2009 Nov;10(5):392-404. doi: 10.1016/j.cmet.2009.09.009.

PMID:
19883617
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

A nutrient-sensitive interaction between Sirt1 and HNF-1α regulates Crp expression.

Grimm AA, Brace CS, Wang T, Stormo GD, Imai S.

Aging Cell. 2011 Apr;10(2):305-17. doi: 10.1111/j.1474-9726.2010.00667.x. Epub 2011 Feb 1.

PMID:
21176092
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Intestinal FXR-mediated FGF15 production contributes to diurnal control of hepatic bile acid synthesis in mice.

Stroeve JH, Brufau G, Stellaard F, Gonzalez FJ, Staels B, Kuipers F.

Lab Invest. 2010 Oct;90(10):1457-67. doi: 10.1038/labinvest.2010.107. Epub 2010 Jun 7.

PMID:
20531290
[PubMed - indexed for MEDLINE]
Free Article

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