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Results: 1 to 20 of 132

1.

Cataract-linked γD-crystallin mutants have weak affinity to lens chaperones α-crystallins.

Mishra S, Stein RA, McHaourab HS.

FEBS Lett. 2012 Feb 17;586(4):330-6. doi: 10.1016/j.febslet.2012.01.019. Epub 2012 Jan 28.

PMID:
22289178
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Cataract-causing defect of a mutant γ-crystallin proceeds through an aggregation pathway which bypasses recognition by the α-crystallin chaperone.

Moreau KL, King JA.

PLoS One. 2012;7(5):e37256. doi: 10.1371/journal.pone.0037256. Epub 2012 May 24.

PMID:
22655036
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

GammaD-crystallin associated protein aggregation and lens fiber cell denucleation.

Wang K, Cheng C, Li L, Liu H, Huang Q, Xia CH, Yao K, Sun P, Horwitz J, Gong X.

Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3719-28.

PMID:
17652744
[PubMed - indexed for MEDLINE]
Free Article
4.

Structural and biochemical characterization of the childhood cataract-associated R76S mutant of human γD-crystallin.

Ji F, Jung J, Gronenborn AM.

Biochemistry. 2012 Mar 27;51(12):2588-96. doi: 10.1021/bi300199d. Epub 2012 Mar 14.

PMID:
22394327
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Partially folded aggregation intermediates of human gammaD-, gammaC-, and gammaS-crystallin are recognized and bound by human alphaB-crystallin chaperone.

Acosta-Sampson L, King J.

J Mol Biol. 2010 Aug 6;401(1):134-52. doi: 10.1016/j.jmb.2010.05.067. Epub 2010 Jun 1.

PMID:
20621668
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Hydrophobic core mutations associated with cataract development in mice destabilize human gammaD-crystallin.

Moreau KL, King J.

J Biol Chem. 2009 Nov 27;284(48):33285-95. doi: 10.1074/jbc.M109.031344. Epub 2009 Sep 16.

PMID:
19758984
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Binding of γ-crystallin substrate prevents the binding of copper and zinc ions to the molecular chaperone α-crystallin.

Ghosh KS, Pande A, Pande J.

Biochemistry. 2011 Apr 26;50(16):3279-81. doi: 10.1021/bi200091q. Epub 2011 Mar 30.

PMID:
21417258
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

A novel gammaD-crystallin mutation causes mild changes in protein properties but leads to congenital coralliform cataract.

Zhang LY, Gong B, Tong JP, Fan DS, Chiang SW, Lou D, Lam DS, Yam GH, Pang CP.

Mol Vis. 2009 Aug 6;15:1521-9.

PMID:
19668596
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

AlphaA-crystallin expression prevents gamma-crystallin insolubility and cataract formation in the zebrafish cloche mutant lens.

Goishi K, Shimizu A, Najarro G, Watanabe S, Rogers R, Zon LI, Klagsbrun M.

Development. 2006 Jul;133(13):2585-93. Epub 2006 May 25.

PMID:
16728471
[PubMed - indexed for MEDLINE]
Free Article
10.

Alteration of protein-protein interactions of congenital cataract crystallin mutants.

Fu L, Liang JJ.

Invest Ophthalmol Vis Sci. 2003 Mar;44(3):1155-9.

PMID:
12601044
[PubMed - indexed for MEDLINE]
Free Article
11.

Susceptibility of ovine lens crystallins to proteolytic cleavage during formation of hereditary cataract.

Robertson LJ, David LL, Riviere MA, Wilmarth PA, Muir MS, Morton JD.

Invest Ophthalmol Vis Sci. 2008 Mar;49(3):1016-22. doi: 10.1167/iovs.07-0792.

PMID:
18326725
[PubMed - indexed for MEDLINE]
Free Article
12.

Enhancement of ubiquitin conjugation activity reduces intracellular aggregation of V76D mutant γD-crystallin.

Liu Z, Taylor A, Liu Y, Wu M, Gong X, Shang F.

Invest Ophthalmol Vis Sci. 2012 Sep 25;53(10):6655-65.

PMID:
22915036
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Modulation of alpha-crystallin chaperone activity: a target to prevent or delay cataract?

Kumar PA, Reddy GB.

IUBMB Life. 2009 May;61(5):485-95. doi: 10.1002/iub.176. Review.

PMID:
19391162
[PubMed - indexed for MEDLINE]
14.

Visualization of in situ intracellular aggregation of two cataract-associated human gamma-crystallin mutants: lose a tail, lose transparency.

Talla V, Srinivasan N, Balasubramanian D.

Invest Ophthalmol Vis Sci. 2008 Aug;49(8):3483-90. doi: 10.1167/iovs.07-1114. Epub 2008 Apr 17.

PMID:
18421082
[PubMed - indexed for MEDLINE]
Free Article
15.

Mutation screening and genotype phenotype correlation of α-crystallin, γ-crystallin and GJA8 gene in congenital cataract.

Kumar M, Agarwal T, Khokhar S, Kumar M, Kaur P, Roy TS, Dada R.

Mol Vis. 2011 Mar 11;17:693-707.

PMID:
21423869
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Removal of Hsf4 leads to cataract development in mice through down-regulation of gamma S-crystallin and Bfsp expression.

Shi X, Cui B, Wang Z, Weng L, Xu Z, Ma J, Xu G, Kong X, Hu L.

BMC Mol Biol. 2009 Feb 19;10:10. doi: 10.1186/1471-2199-10-10.

PMID:
19224648
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Cataract-associated mutant E107A of human gammaD-crystallin shows increased attraction to alpha-crystallin and enhanced light scattering.

Banerjee PR, Pande A, Patrosz J, Thurston GM, Pande J.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):574-9. doi: 10.1073/pnas.1014653107. Epub 2010 Dec 20.

PMID:
21173272
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Increased hydrophobicity and decreased backbone flexibility explain the lower solubility of a cataract-linked mutant of γD-crystallin.

Banerjee PR, Puttamadappa SS, Pande A, Shekhtman A, Pande J.

J Mol Biol. 2011 Sep 30;412(4):647-59. doi: 10.1016/j.jmb.2011.07.058. Epub 2011 Jul 30.

PMID:
21827768
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Crystallin {gamma}B-I4F mutant protein binds to {alpha}-crystallin and affects lens transparency.

Liu H, Du X, Wang M, Huang Q, Ding L, McDonald HW, Yates JR 3rd, Beutler B, Horwitz J, Gong X.

J Biol Chem. 2005 Jul 1;280(26):25071-8. Epub 2005 May 4.

PMID:
15878859
[PubMed - indexed for MEDLINE]
Free Article
20.

Biophysical properties of gammaC-crystallin in human and mouse eye lens: the role of molecular dipoles.

Purkiss AG, Bateman OA, Wyatt K, Wilmarth PA, David LL, Wistow GJ, Slingsby C.

J Mol Biol. 2007 Sep 7;372(1):205-22. Epub 2007 Jun 26.

PMID:
17659303
[PubMed - indexed for MEDLINE]
Free PMC Article

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