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Results: 1 to 20 of 107

1.

Discovery of potent and selective covalent inhibitors of JNK.

Zhang T, Inesta-Vaquera F, Niepel M, Zhang J, Ficarro SB, Machleidt T, Xie T, Marto JA, Kim N, Sim T, Laughlin JD, Park H, LoGrasso PV, Patricelli M, Nomanbhoy TK, Sorger PK, Alessi DR, Gray NS.

Chem Biol. 2012 Jan 27;19(1):140-54. doi: 10.1016/j.chembiol.2011.11.010.

PMID:
22284361
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): kinase profiling guided optimization of a 1,2,3-benzotriazole lead.

Palmer WS, Alam M, Arzeno HB, Chang KC, Dunn JP, Goldstein DM, Gong L, Goyal B, Hermann JC, Hogg JH, Hsieh G, Jahangir A, Janson C, Jin S, Ursula Kammlott R, Kuglstatter A, Lukacs C, Michoud C, Niu L, Reuter DC, Shao A, Silva T, Trejo-Martin TA, Stein K, Tan YC, Tivitmahaisoon P, Tran P, Wagner P, Weller P, Wu SY.

Bioorg Med Chem Lett. 2013 Mar 1;23(5):1486-92. doi: 10.1016/j.bmcl.2012.12.047. Epub 2012 Dec 22.

PMID:
23352510
[PubMed - indexed for MEDLINE]
3.

A novel retro-inverso peptide is a preferential JNK substrate-competitive inhibitor.

Ngoei KR, Catimel B, Milech N, Watt PM, Bogoyevitch MA.

Int J Biochem Cell Biol. 2013 Aug;45(8):1939-50. doi: 10.1016/j.biocel.2013.06.006. Epub 2013 Jun 19.

PMID:
23792175
[PubMed - indexed for MEDLINE]
4.

Discovery of a novel series of 4-quinolone JNK inhibitors.

Gong L, Tan YC, Boice G, Abbot S, McCaleb K, Iyer P, Zuo F, Dal Porto J, Wong B, Jin S, Chang A, Tran P, Hsieh G, Niu L, Shao A, Reuter D, Lukacs CM, Ursula Kammlott R, Kuglstatter A, Goldstein D.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7381-7. doi: 10.1016/j.bmcl.2012.10.066. Epub 2012 Oct 24.

PMID:
23142618
[PubMed - indexed for MEDLINE]
5.

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1).

Asano Y, Kitamura S, Ohra T, Aso K, Igata H, Tamura T, Kawamoto T, Tanaka T, Sogabe S, Matsumoto S, Yamaguchi M, Kimura H, Itoh F.

Bioorg Med Chem. 2008 Apr 15;16(8):4715-32. doi: 10.1016/j.bmc.2008.02.027. Epub 2008 Feb 13.

PMID:
18313304
[PubMed - indexed for MEDLINE]
6.

Exendin-4 prevents c-Jun N-terminal protein kinase activation by tumor necrosis factor-alpha (TNFalpha) and inhibits TNFalpha-induced apoptosis in insulin-secreting cells.

Natalicchio A, De Stefano F, Orlando MR, Melchiorre M, Leonardini A, Cignarelli A, Labarbuta R, Marchetti P, Perrini S, Laviola L, Giorgino F.

Endocrinology. 2010 May;151(5):2019-29. doi: 10.1210/en.2009-1166. Epub 2010 Mar 10.

PMID:
20219981
[PubMed - indexed for MEDLINE]
7.

Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): optimization for JNK potency and physicochemical properties.

Gong L, Han X, Silva T, Tan YC, Goyal B, Tivitmahaisoon P, Trejo A, Palmer W, Hogg H, Jahagir A, Alam M, Wagner P, Stein K, Filonova L, Loe B, Makra F, Rotstein D, Rapatova L, Dunn J, Zuo F, Dal Porto J, Wong B, Jin S, Chang A, Tran P, Hsieh G, Niu L, Shao A, Reuter D, Hermann J, Kuglstatter A, Goldstein D.

Bioorg Med Chem Lett. 2013 Jun 15;23(12):3565-9. doi: 10.1016/j.bmcl.2013.04.029. Epub 2013 Apr 21.

PMID:
23664880
[PubMed - indexed for MEDLINE]
8.

Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases.

Comess KM, Sun C, Abad-Zapatero C, Goedken ER, Gum RJ, Borhani DW, Argiriadi M, Groebe DR, Jia Y, Clampit JE, Haasch DL, Smith HT, Wang S, Song D, Coen ML, Cloutier TE, Tang H, Cheng X, Quinn C, Liu B, Xin Z, Liu G, Fry EH, Stoll V, Ng TI, Banach D, Marcotte D, Burns DJ, Calderwood DJ, Hajduk PJ.

ACS Chem Biol. 2011 Mar 18;6(3):234-44. doi: 10.1021/cb1002619. Epub 2011 Jan 20.

PMID:
21090814
[PubMed - indexed for MEDLINE]
9.

Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors.

Shin Y, Chen W, Habel J, Duckett D, Ling YY, Koenig M, He Y, Vojkovsky T, LoGrasso P, Kamenecka TM.

Bioorg Med Chem Lett. 2009 Jun 15;19(12):3344-7. doi: 10.1016/j.bmcl.2009.03.086. Epub 2009 Mar 26.

PMID:
19433357
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors.

He Y, Duckett D, Chen W, Ling YY, Cameron MD, Lin L, Ruiz CH, Lograsso PV, Kamenecka TM, Koenig M.

Bioorg Med Chem Lett. 2014 Jan 1;24(1):161-4. doi: 10.1016/j.bmcl.2013.11.052. Epub 2013 Dec 4.

PMID:
24332487
[PubMed - indexed for MEDLINE]
11.

JNK and ERK mitogen-activated protein kinases mediate THDA-induced apoptosis in K562 cells.

Yang SH, Wu ZZ, Chien CM, Lo YH, Wu MJ, Chang LS, Lin SR.

Cell Biol Toxicol. 2008 Aug;24(4):291-302. Epub 2007 Oct 13.

PMID:
17934787
[PubMed - indexed for MEDLINE]
12.

Activation of c-Jun N-terminal kinase (JNK) by widely used specific p38 MAPK inhibitors SB202190 and SB203580: a MLK-3-MKK7-dependent mechanism.

Muniyappa H, Das KC.

Cell Signal. 2008 Apr;20(4):675-83. doi: 10.1016/j.cellsig.2007.12.003. Epub 2007 Dec 8.

PMID:
18222647
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway.

Ito M, Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, Hibi M, Nakabeppu Y, Shiba T, Yamamoto KI.

Mol Cell Biol. 1999 Nov;19(11):7539-48.

PMID:
10523642
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Synthesis and SAR of 2-phenoxypyridines as novel c-Jun N-terminal kinase inhibitors.

Song X, Chen W, Lin L, Ruiz CH, Cameron MD, Duckett DR, Kamenecka TM.

Bioorg Med Chem Lett. 2011 Dec 1;21(23):7072-5. doi: 10.1016/j.bmcl.2011.09.090. Epub 2011 Sep 29.

PMID:
22004719
[PubMed - indexed for MEDLINE]
15.

c-Jun N-terminal kinase binding domain-dependent phosphorylation of mitogen-activated protein kinase kinase 4 and mitogen-activated protein kinase kinase 7 and balancing cross-talk between c-Jun N-terminal kinase and extracellular signal-regulated kinase pathways in cortical neurons.

Repici M, Mare L, Colombo A, Ploia C, Sclip A, Bonny C, Nicod P, Salmona M, Borsello T.

Neuroscience. 2009 Mar 3;159(1):94-103. doi: 10.1016/j.neuroscience.2008.11.049. Epub 2008 Dec 14.

PMID:
19135136
[PubMed - indexed for MEDLINE]
16.

The protein kinase C inhibitor, Ro-31-7459, is a potent activator of ERK and JNK MAP kinases in HUVECs and yet inhibits cyclic AMP-stimulated SOCS-3 gene induction through inactivation of the transcription factor c-Jun.

Wiejak J, Dunlop J, Stoyle C, Lappin G, McIlroy A, Pediani JD, Gao S, Yarwood SJ.

Cell Signal. 2012 Aug;24(8):1690-9. doi: 10.1016/j.cellsig.2012.04.016. Epub 2012 Apr 25.

PMID:
22561846
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

c-jun amino-terminal kinase and mitogen activated protein kinase 1/2 mediate hepatocyte growth factor-induced migration of brain endothelial cells.

Rush S, Khan G, Bamisaiye A, Bidwell P, Leaver HA, Rizzo MT.

Exp Cell Res. 2007 Jan 1;313(1):121-32. Epub 2006 Sep 26.

PMID:
17055484
[PubMed - indexed for MEDLINE]
18.

Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) inhibitors.

He Y, Kamenecka TM, Shin Y, Song X, Jiang R, Noel R, Duckett D, Chen W, Ling YY, Cameron MD, Lin L, Khan S, Koenig M, LoGrasso PV.

Bioorg Med Chem Lett. 2011 Mar 15;21(6):1719-23. doi: 10.1016/j.bmcl.2011.01.079. Epub 2011 Jan 22.

PMID:
21316221
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

c-Jun N-terminal kinase mediates microtubule-depolymerizing agent-induced microtubule depolymerization and G2/M arrest in MCF-7 breast cancer cells.

Chen J, Sun WL, Wasylyk B, Wang YP, Zheng H.

Anticancer Drugs. 2012 Jan;23(1):98-107. doi: 10.1097/CAD.0b013e32834bc978.

PMID:
21968419
[PubMed - indexed for MEDLINE]
20.

Role of the JNK/c-Jun/AP-1 signaling pathway in galectin-1-induced T-cell death.

Brandt B, Abou-Eladab EF, Tiedge M, Walzel H.

Cell Death Dis. 2010;1:e23. doi: 10.1038/cddis.2010.1.

PMID:
21364631
[PubMed - indexed for MEDLINE]
Free PMC Article

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