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An enhancer from the 8q24 prostate cancer risk region is sufficient to direct reporter gene expression to a subset of prostate stem-like epithelial cells in transgenic mice.

Ting MC, Liao CP, Yan C, Jia L, Groshen S, Frenkel B, Roy-Burman P, Coetzee GA, Maxson R.

Dis Model Mech. 2012 May;5(3):366-74. doi: 10.1242/dmm.008458. Epub 2012 Jan 25.


An 8q24 gene desert variant associated with prostate cancer risk confers differential in vivo activity to a MYC enhancer.

Wasserman NF, Aneas I, Nobrega MA.

Genome Res. 2010 Sep;20(9):1191-7. doi: 10.1101/gr.105361.110. Epub 2010 Jul 13.


Networks of intergenic long-range enhancers and snpRNAs drive castration-resistant phenotype of prostate cancer and contribute to pathogenesis of multiple common human disorders.

Glinskii AB, Ma S, Ma J, Grant D, Lim CU, Guest I, Sell S, Buttyan R, Glinsky GV.

Cell Cycle. 2011 Oct 15;10(20):3571-97. doi: 10.4161/cc.10.20.17842.


A luminal epithelial stem cell that is a cell of origin for prostate cancer.

Wang X, Kruithof-de Julio M, Economides KD, Walker D, Yu H, Halili MV, Hu YP, Price SM, Abate-Shen C, Shen MM.

Nature. 2009 Sep 24;461(7263):495-500. doi: 10.1038/nature08361. Epub 2009 Sep 9.


Distinct regulatory elements mediate the dynamic expression pattern of Nkx3.1.

Chen H, Mutton LN, Prins GS, Bieberich CJ.

Dev Dyn. 2005 Dec;234(4):961-73.


The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling.

Tuupanen S, Turunen M, Lehtonen R, Hallikas O, Vanharanta S, Kivioja T, Björklund M, Wei G, Yan J, Niittymäki I, Mecklin JP, Järvinen H, Ristimäki A, Di-Bernardo M, East P, Carvajal-Carmona L, Houlston RS, Tomlinson I, Palin K, Ukkonen E, Karhu A, Taipale J, Aaltonen LA.

Nat Genet. 2009 Aug;41(8):885-90. doi: 10.1038/ng.406. Epub 2009 Jun 28.


Germ-line mutation of NKX3.1 cosegregates with hereditary prostate cancer and alters the homeodomain structure and function.

Zheng SL, Ju JH, Chang BL, Ortner E, Sun J, Isaacs SD, Sun J, Wiley KE, Liu W, Zemedkun M, Walsh PC, Ferretti J, Gruschus J, Isaacs WB, Gelmann EP, Xu J.

Cancer Res. 2006 Jan 1;66(1):69-77.


A functional variant at a prostate cancer predisposition locus at 8q24 is associated with PVT1 expression.

Meyer KB, Maia AT, O'Reilly M, Ghoussaini M, Prathalingam R, Porter-Gill P, Ambs S, Prokunina-Olsson L, Carroll J, Ponder BA.

PLoS Genet. 2011 Jul;7(7):e1002165. doi: 10.1371/journal.pgen.1002165. Epub 2011 Jul 21.


A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer.

He WW, Sciavolino PJ, Wing J, Augustus M, Hudson P, Meissner PS, Curtis RT, Shell BK, Bostwick DG, Tindall DJ, Gelmann EP, Abate-Shen C, Carter KC.

Genomics. 1997 Jul 1;43(1):69-77.


Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis.

Song H, Zhang B, Watson MA, Humphrey PA, Lim H, Milbrandt J.

Oncogene. 2009 Sep 17;28(37):3307-19. doi: 10.1038/onc.2009.181. Epub 2009 Jul 13.


Prostate targeting: PSP94 gene promoter/enhancer region directed prostate tissue-specific expression in a transgenic mouse prostate cancer model.

Gabril MY, Onita T, Ji PG, Sakai H, Chan FL, Koropatnick J, Chin JL, Moussa M, Xuan JW.

Gene Ther. 2002 Dec;9(23):1589-99.


Emergence of androgen independence at early stages of prostate cancer progression in Nkx3.1; Pten mice.

Gao H, Ouyang X, Banach-Petrosky WA, Shen MM, Abate-Shen C.

Cancer Res. 2006 Aug 15;66(16):7929-33.


A FOXA1-binding enhancer regulates Hoxb13 expression in the prostate gland.

McMullin RP, Dobi A, Mutton LN, Orosz A, Maheshwari S, Shashikant CS, Bieberich CJ.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):98-103. doi: 10.1073/pnas.0902001107. Epub 2009 Dec 14.


A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding.

Huang Q, Whitington T, Gao P, Lindberg JF, Yang Y, Sun J, Väisänen MR, Szulkin R, Annala M, Yan J, Egevad LA, Zhang K, Lin R, Jolma A, Nykter M, Manninen A, Wiklund F, Vaarala MH, Visakorpi T, Xu J, Taipale J, Wei GH.

Nat Genet. 2014 Feb;46(2):126-35. doi: 10.1038/ng.2862. Epub 2014 Jan 5.


Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5.

Kim T, Cui R, Jeon YJ, Lee JH, Lee JH, Sim H, Park JK, Fadda P, Tili E, Nakanishi H, Huh MI, Kim SH, Cho JH, Sung BH, Peng Y, Lee TJ, Luo Z, Sun HL, Wei H, Alder H, Oh JS, Shim KS, Ko SB, Croce CM.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4173-8. doi: 10.1073/pnas.1400350111. Epub 2014 Mar 4.


NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss.

Lei Q, Jiao J, Xin L, Chang CJ, Wang S, Gao J, Gleave ME, Witte ON, Liu X, Wu H.

Cancer Cell. 2006 May;9(5):367-78.


Progenitor cells for the prostate epithelium: roles in development, regeneration, and cancer.

Shen MM, Wang X, Economides KD, Walker D, Abate-Shen C.

Cold Spring Harb Symp Quant Biol. 2008;73:529-38. doi: 10.1101/sqb.2008.73.050. Epub 2009 Jan 15. Review.


Upregulation of c-MYC in cis through a large chromatin loop linked to a cancer risk-associated single-nucleotide polymorphism in colorectal cancer cells.

Wright JB, Brown SJ, Cole MD.

Mol Cell Biol. 2010 Mar;30(6):1411-20. doi: 10.1128/MCB.01384-09. Epub 2010 Jan 11.


Multiple regions within 8q24 independently affect risk for prostate cancer.

Haiman CA, Patterson N, Freedman ML, Myers SR, Pike MC, Waliszewska A, Neubauer J, Tandon A, Schirmer C, McDonald GJ, Greenway SC, Stram DO, Le Marchand L, Kolonel LN, Frasco M, Wong D, Pooler LC, Ardlie K, Oakley-Girvan I, Whittemore AS, Cooney KA, John EM, Ingles SA, Altshuler D, Henderson BE, Reich D.

Nat Genet. 2007 May;39(5):638-44. Epub 2007 Apr 1.


Genome-wide association study of prostate cancer identifies a second risk locus at 8q24.

Yeager M, Orr N, Hayes RB, Jacobs KB, Kraft P, Wacholder S, Minichiello MJ, Fearnhead P, Yu K, Chatterjee N, Wang Z, Welch R, Staats BJ, Calle EE, Feigelson HS, Thun MJ, Rodriguez C, Albanes D, Virtamo J, Weinstein S, Schumacher FR, Giovannucci E, Willett WC, Cancel-Tassin G, Cussenot O, Valeri A, Andriole GL, Gelmann EP, Tucker M, Gerhard DS, Fraumeni JF Jr, Hoover R, Hunter DJ, Chanock SJ, Thomas G.

Nat Genet. 2007 May;39(5):645-9. Epub 2007 Apr 1.

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