Format
Items per page
Sort by

Send to:

Choose Destination

Links from PubMed

Items: 1 to 20 of 98

1.

Increased Diels-Alderase activity through backbone remodeling guided by Foldit players.

Eiben CB, Siegel JB, Bale JB, Cooper S, Khatib F, Shen BW, Players F, Stoddard BL, Popovic Z, Baker D.

Nat Biotechnol. 2012 Jan 22;30(2):190-2. doi: 10.1038/nbt.2109.

2.

Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction.

Siegel JB, Zanghellini A, Lovick HM, Kiss G, Lambert AR, St Clair JL, Gallaher JL, Hilvert D, Gelb MH, Stoddard BL, Houk KN, Michael FE, Baker D.

Science. 2010 Jul 16;329(5989):309-13. doi: 10.1126/science.1190239.

3.

Kemp elimination catalysts by computational enzyme design.

Röthlisberger D, Khersonsky O, Wollacott AM, Jiang L, DeChancie J, Betker J, Gallaher JL, Althoff EA, Zanghellini A, Dym O, Albeck S, Houk KN, Tawfik DS, Baker D.

Nature. 2008 May 8;453(7192):190-5. doi: 10.1038/nature06879. Epub 2008 Mar 19.

PMID:
18354394
4.

Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase.

Preiswerk N, Beck T, Schulz JD, Milovník P, Mayer C, Siegel JB, Baker D, Hilvert D.

Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8013-8. doi: 10.1073/pnas.1401073111. Epub 2014 May 20.

5.

Design of protein catalysts.

Hilvert D.

Annu Rev Biochem. 2013;82:447-70. doi: 10.1146/annurev-biochem-072611-101825. Review.

PMID:
23746259
6.

Alteration of enzyme specificity by computational loop remodeling and design.

Murphy PM, Bolduc JM, Gallaher JL, Stoddard BL, Baker D.

Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9215-20. doi: 10.1073/pnas.0811070106. Epub 2009 May 21.

7.

Iterative approach to computational enzyme design.

Privett HK, Kiss G, Lee TM, Blomberg R, Chica RA, Thomas LM, Hilvert D, Houk KN, Mayo SL.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3790-5. doi: 10.1073/pnas.1118082108. Epub 2012 Feb 22.

8.

De novo design of catalytic proteins.

Kaplan J, DeGrado WF.

Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11566-70. Epub 2004 Aug 3.

9.

Enzyme-like proteins from an unselected library of designed amino acid sequences.

Wei Y, Hecht MH.

Protein Eng Des Sel. 2004 Jan;17(1):67-75.

10.

De novo enzymes by computational design.

Kries H, Blomberg R, Hilvert D.

Curr Opin Chem Biol. 2013 Apr;17(2):221-8. doi: 10.1016/j.cbpa.2013.02.012. Epub 2013 Mar 14. Review.

PMID:
23498973
11.

New algorithms and an in silico benchmark for computational enzyme design.

Zanghellini A, Jiang L, Wollacott AM, Cheng G, Meiler J, Althoff EA, Röthlisberger D, Baker D.

Protein Sci. 2006 Dec;15(12):2785-94.

12.

Computational enzyme design.

Kiss G, Çelebi-Ölçüm N, Moretti R, Baker D, Houk KN.

Angew Chem Int Ed Engl. 2013 May 27;52(22):5700-25. doi: 10.1002/anie.201204077. Epub 2013 Mar 25. Review.

PMID:
23526810
13.

Predicting protein structures with a multiplayer online game.

Cooper S, Khatib F, Treuille A, Barbero J, Lee J, Beenen M, Leaver-Fay A, Baker D, Popović Z, Players F.

Nature. 2010 Aug 5;466(7307):756-60. doi: 10.1038/nature09304.

14.

The influence of protein dynamics on the success of computational enzyme design.

Ruscio JZ, Kohn JE, Ball KA, Head-Gordon T.

J Am Chem Soc. 2009 Oct 7;131(39):14111-5. doi: 10.1021/ja905396s.

15.

A computational approach to enzyme design: predicting ω-aminotransferase catalytic activity using docking and MM-GBSA scoring.

Sirin S, Kumar R, Martinez C, Karmilowicz MJ, Ghosh P, Abramov YA, Martin V, Sherman W.

J Chem Inf Model. 2014 Aug 25;54(8):2334-46. doi: 10.1021/ci5002185. Epub 2014 Jul 22.

PMID:
25005922
16.

Intelligent design: the de novo engineering of proteins with specified functions.

Koder RL, Dutton PL.

Dalton Trans. 2006 Jul 7;(25):3045-51. Epub 2006 May 31.

PMID:
16786062
17.

De novo computational design of retro-aldol enzymes.

Jiang L, Althoff EA, Clemente FR, Doyle L, Röthlisberger D, Zanghellini A, Gallaher JL, Betker JL, Tanaka F, Barbas CF 3rd, Hilvert D, Houk KN, Stoddard BL, Baker D.

Science. 2008 Mar 7;319(5868):1387-91. doi: 10.1126/science.1152692.

19.

Computational design of novel enzymes without cofactors.

Smith MD, Zanghellini A, Grabs-Röthlisberger D.

Methods Mol Biol. 2014;1216:197-210. doi: 10.1007/978-1-4939-1486-9_10. Review.

PMID:
25213417
20.

De novo enzyme design using Rosetta3.

Richter F, Leaver-Fay A, Khare SD, Bjelic S, Baker D.

PLoS One. 2011;6(5):e19230. doi: 10.1371/journal.pone.0019230. Epub 2011 May 16.

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk