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Items: 1 to 20 of 119


Get5 carboxyl-terminal domain is a novel dimerization motif that tethers an extended Get4/Get5 complex.

Chartron JW, VanderVelde DG, Rao M, Clemons WM Jr.

J Biol Chem. 2012 Mar 9;287(11):8310-7. doi: 10.1074/jbc.M111.333252. Epub 2012 Jan 17.


Interaction surface and topology of Get3-Get4-Get5 protein complex, involved in targeting tail-anchored proteins to endoplasmic reticulum.

Chang YW, Lin TW, Li YC, Huang YS, Sun YJ, Hsiao CD.

J Biol Chem. 2012 Feb 10;287(7):4783-9. doi: 10.1074/jbc.M111.318329. Epub 2011 Dec 21.


Structural characterization of the Get4/Get5 complex and its interaction with Get3.

Chartron JW, Suloway CJ, Zaslaver M, Clemons WM Jr.

Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12127-32. doi: 10.1073/pnas.1006036107. Epub 2010 Jun 16.


Crystal structure of Get4-Get5 complex and its interactions with Sgt2, Get3, and Ydj1.

Chang YW, Chuang YC, Ho YC, Cheng MY, Sun YJ, Hsiao CD, Wang C.

J Biol Chem. 2010 Mar 26;285(13):9962-70. doi: 10.1074/jbc.M109.087098. Epub 2010 Jan 27.


A structural model of the Sgt2 protein and its interactions with chaperones and the Get4/Get5 complex.

Chartron JW, Gonzalez GM, Clemons WM Jr.

J Biol Chem. 2011 Sep 30;286(39):34325-34. doi: 10.1074/jbc.M111.277798. Epub 2011 Aug 10.


Crystal structure of ATP-bound Get3-Get4-Get5 complex reveals regulation of Get3 by Get4.

Gristick HB, Rao M, Chartron JW, Rome ME, Shan SO, Clemons WM Jr.

Nat Struct Mol Biol. 2014 May;21(5):437-42. doi: 10.1038/nsmb.2813. Epub 2014 Apr 13.


Structures of Get3, Get4, and Get5 provide new models for TA membrane protein targeting.

Simpson PJ, Schwappach B, Dohlman HG, Isaacson RL.

Structure. 2010 Aug 11;18(8):897-902. doi: 10.1016/j.str.2010.07.003. Review.


Structure of the Sgt2 dimerization domain complexed with the Get5 UBL domain involved in the targeting of tail-anchored membrane proteins to the endoplasmic reticulum.

Tung JY, Li YC, Lin TW, Hsiao CD.

Acta Crystallogr D Biol Crystallogr. 2013 Oct;69(Pt 10):2081-90. doi: 10.1107/S0907444913019379. Epub 2013 Sep 20.


Structure of the Sgt2/Get5 complex provides insights into GET-mediated targeting of tail-anchored membrane proteins.

Simon AC, Simpson PJ, Goldstone RM, Krysztofinska EM, Murray JW, High S, Isaacson RL.

Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1327-32. doi: 10.1073/pnas.1207518110. Epub 2013 Jan 7.


Structures of the Sgt2/SGTA dimerization domain with the Get5/UBL4A UBL domain reveal an interaction that forms a conserved dynamic interface.

Chartron JW, VanderVelde DG, Clemons WM Jr.

Cell Rep. 2012 Dec 27;2(6):1620-32. doi: 10.1016/j.celrep.2012.10.010. Epub 2012 Nov 8.


1H, 13C and 15N assignments of Sgt2 N-terminal dimerisation domain and its binding partner, Get5 Ubiquitin-like domain.

Simon AC, Simpson PJ, Hawthorne W, Hale LR, Goldstone RM, Isaacson RL.

Biomol NMR Assign. 2013 Oct;7(2):271-4. doi: 10.1007/s12104-012-9425-7. Epub 2012 Sep 22.


Structural basis for tail-anchored membrane protein biogenesis by the Get3-receptor complex.

Stefer S, Reitz S, Wang F, Wild K, Pang YY, Schwarz D, Bomke J, Hein C, Löhr F, Bernhard F, Denic V, Dötsch V, Sinning I.

Science. 2011 Aug 5;333(6043):758-62. doi: 10.1126/science.1207125. Epub 2011 Jun 30.


Model for eukaryotic tail-anchored protein binding based on the structure of Get3.

Suloway CJ, Chartron JW, Zaslaver M, Clemons WM Jr.

Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14849-54. doi: 10.1073/pnas.0907522106. Epub 2009 Aug 14.


The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase.

Wang F, Chan C, Weir NR, Denic V.

Nature. 2014 Aug 28;512(7515):441-4. doi: 10.1038/nature13471. Epub 2014 Jul 20.


Structural and functional characterization of ybr137wp implicates its involvement in the targeting of tail-anchored proteins to membranes.

Yeh YH, Lin TW, Li YC, Tung JY, Lin CY, Hsiao CD.

Mol Cell Biol. 2014 Dec;34(24):4500-12. doi: 10.1128/MCB.00697-14. Epub 2014 Oct 6.


The structural basis of tail-anchored membrane protein recognition by Get3.

Mateja A, Szlachcic A, Downing ME, Dobosz M, Mariappan M, Hegde RS, Keenan RJ.

Nature. 2009 Sep 17;461(7262):361-6. doi: 10.1038/nature08319. Epub 2009 Aug 12.


Structural insight into the membrane insertion of tail-anchored proteins by Get3.

Yamagata A, Mimura H, Sato Y, Yamashita M, Yoshikawa A, Fukai S.

Genes Cells. 2010 Jan;15(1):29-41. doi: 10.1111/j.1365-2443.2009.01362.x. Epub 2009 Dec 15.


Cooperative and independent activities of Sgt2 and Get5 in the targeting of tail-anchored proteins.

Kohl C, Tessarz P, von der Malsburg K, Zahn R, Bukau B, Mogk A.

Biol Chem. 2011 Jul;392(7):601-8. doi: 10.1515/BC.2011.066. Epub 2011 May 28.


The crystal structures of yeast Get3 suggest a mechanism for tail-anchored protein membrane insertion.

Hu J, Li J, Qian X, Denic V, Sha B.

PLoS One. 2009 Nov 30;4(11):e8061. doi: 10.1371/journal.pone.0008061.


Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo.

Mateja A, Paduch M, Chang HY, Szydlowska A, Kossiakoff AA, Hegde RS, Keenan RJ.

Science. 2015 Mar 6;347(6226):1152-5. doi: 10.1126/science.1261671.

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