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Results: 1 to 20 of 106

1.

An activity-based near-infrared glucuronide trapping probe for imaging β-glucuronidase expression in deep tissues.

Cheng TC, Roffler SR, Tzou SC, Chuang KH, Su YC, Chuang CH, Kao CH, Chen CS, Harn IH, Liu KY, Cheng TL, Leu YL.

J Am Chem Soc. 2012 Feb 15;134(6):3103-10. doi: 10.1021/ja209335z. Epub 2012 Feb 1.

PMID:
22239495
[PubMed - indexed for MEDLINE]
2.

N'-Fluorescein-N''-[4-O-(β-d-glucopyranuronic acid)-3-difluoromethylphenyl]-S-methylthiourea (FITC-TrapG) and N'-(p-aminophenyl)thioether of IR-820-N''-[4-O-(β-d-glucopyranuronic acid)-3-difluoromethylphenyl]-S-methylthiourea (NIR-TrapG).

Chopra A.

Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013.
2012 Apr 10 [updated 2012 May 10].

3.

PET Imaging of β-Glucuronidase Activity by an Activity-Based 124I-Trapping Probe for the Personalized Glucuronide Prodrug Targeted Therapy.

Su YC, Cheng TC, Leu YL, Roffler SR, Wang JY, Chuang CH, Kao CH, Chen KC, Wang HE, Cheng TL.

Mol Cancer Ther. 2014 Dec;13(12):2852-63. doi: 10.1158/1535-7163.MCT-14-0212. Epub 2014 Oct 2.

PMID:
25277385
[PubMed - in process]
4.

Gene expression imaging by enzymatic catalysis of a fluorescent probe via membrane-anchored beta-glucuronidase.

Su YC, Chuang KH, Wang YM, Cheng CM, Lin SR, Wang JY, Hwang JJ, Chen BM, Chen KC, Roffler S, Cheng TL.

Gene Ther. 2007 Apr;14(7):565-74. Epub 2007 Jan 18.

PMID:
17235292
[PubMed - indexed for MEDLINE]
5.

Beta-glucuronidase-mediated drug release.

de Graaf M, Boven E, Scheeren HW, Haisma HJ, Pinedo HM.

Curr Pharm Des. 2002;8(15):1391-403. Review.

PMID:
12052215
[PubMed - indexed for MEDLINE]
6.

Membrane-localized activation of glucuronide prodrugs by beta-glucuronidase enzymes.

Chen KC, Cheng TL, Leu YL, Prijovich ZM, Chuang CH, Chen BM, Roffler SR.

Cancer Gene Ther. 2007 Feb;14(2):187-200. Epub 2006 Sep 15.

PMID:
16977328
[PubMed - indexed for MEDLINE]
7.

A versatile technique for the in vivo imaging of human tumor xenografts using near-infrared fluorochrome-conjugated macromolecule probes.

Suemizu H, Kawai K, Higuchi Y, Hashimoto H, Ogura T, Itoh T, Sasaki E, Nakamura M.

PLoS One. 2013 Dec 17;8(12):e82708. doi: 10.1371/journal.pone.0082708. eCollection 2013.

PMID:
24358218
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Selective cancer therapy by extracellular activation of a highly potent glycosidic duocarmycin analogue.

Chen KC, Schmuck K, Tietze LF, Roffler SR.

Mol Pharm. 2013 May 6;10(5):1773-82. doi: 10.1021/mp300581u. Epub 2013 Mar 26.

PMID:
23448264
[PubMed - indexed for MEDLINE]
9.

A humanized immunoenzyme with enhanced activity for glucuronide prodrug activation in the tumor microenvironment.

Chen KC, Wu SY, Leu YL, Prijovich ZM, Chen BM, Wang HE, Cheng TL, Roffler SR.

Bioconjug Chem. 2011 May 18;22(5):938-48. doi: 10.1021/bc1005784. Epub 2011 Apr 12.

PMID:
21443266
[PubMed - indexed for MEDLINE]
10.

Micro-PET imaging of beta-glucuronidase activity by the hydrophobic conversion of a glucuronide probe.

Tzou SC, Roffler S, Chuang KH, Yeh HP, Kao CH, Su YC, Cheng CM, Tseng WL, Shiea J, Harm IH, Cheng KW, Chen BM, Hwang JJ, Cheng TL, Wang HE.

Radiology. 2009 Sep;252(3):754-62. doi: 10.1148/radiol.2523082055.

PMID:
19717754
[PubMed - indexed for MEDLINE]
11.

Benzyl ether-linked glucuronide derivative of 10-hydroxycamptothecin designed for selective camptothecin-based anticancer therapy.

Leu YL, Chen CS, Wu YJ, Chern JW.

J Med Chem. 2008 Mar 27;51(6):1740-6. doi: 10.1021/jm701151c. Epub 2008 Mar 5.

PMID:
18318465
[PubMed - indexed for MEDLINE]
12.

Expression of β-glucuronidase on the surface of bacteria enhances activation of glucuronide prodrugs.

Cheng CM, Chen FM, Lu YL, Tzou SC, Wang JY, Kao CH, Liao KW, Cheng TC, Chuang CH, Chen BM, Roffler S, Cheng TL.

Cancer Gene Ther. 2013 May;20(5):276-81. doi: 10.1038/cgt.2013.17. Epub 2013 Apr 19.

PMID:
23598434
[PubMed - indexed for MEDLINE]
13.

Chimeric TNT-3/human beta-glucuronidase fusion proteins for antibody-directed enzyme prodrug therapy (ADEPT).

Biela BH, Khawli LA, Hu P, Epstein AL.

Cancer Biother Radiopharm. 2003 Jun;18(3):339-53.

PMID:
12954121
[PubMed - indexed for MEDLINE]
14.

Stability and enzymatic hydrolysis of quaternary ammonium-linked glucuronide metabolites of drugs with an aliphatic tertiary amine-implications for analysis.

Kowalczyk I, Hawes EM, McKay G.

J Pharm Biomed Anal. 2000 Jun;22(5):803-11.

PMID:
10815723
[PubMed - indexed for MEDLINE]
15.

In vivo tumor imaging using a near-infrared-labeled endostatin molecule.

Citrin D, Scott T, Sproull M, Menard C, Tofilon PJ, Camphausen K.

Int J Radiat Oncol Biol Phys. 2004 Feb 1;58(2):536-41.

PMID:
14751525
[PubMed - indexed for MEDLINE]
16.

Local enzymatic hydrolysis of an endogenously generated metabolite can enhance CPT-11 anticancer efficacy.

Prijovich ZM, Chen KC, Roffler SR.

Mol Cancer Ther. 2009 Apr;8(4):940-6. doi: 10.1158/1535-7163.MCT-08-0812.

PMID:
19372567
[PubMed - indexed for MEDLINE]
Free Article
17.

Pronounced antitumor efficacy of doxorubicin when given as the prodrug DOX-GA3 in combination with a monoclonal antibody beta-glucuronidase conjugate.

Houba PH, Boven E, van der Meulen-Muileman IH, Leenders RG, Scheeren JW, Pinedo HM, Haisma HJ.

Int J Cancer. 2001 Feb 15;91(4):550-4.

PMID:
11251980
[PubMed - indexed for MEDLINE]
18.

Enhanced tumor detection using a folate receptor-targeted near-infrared fluorochrome conjugate.

Moon WK, Lin Y, O'Loughlin T, Tang Y, Kim DE, Weissleder R, Tung CH.

Bioconjug Chem. 2003 May-Jun;14(3):539-45.

PMID:
12757377
[PubMed - indexed for MEDLINE]
19.

Synthesis and evaluation of [18F]-FEAnGA as a PET Tracer for beta-glucuronidase activity.

Antunes IF, Haisma HJ, Elsinga PH, Dierckx RA, de Vries EF.

Bioconjug Chem. 2010 May 19;21(5):911-20. doi: 10.1021/bc9004602.

PMID:
20415436
[PubMed - indexed for MEDLINE]
20.

A near-infrared fluorescent heptamethine indocyanine dye with preferential tumor accumulation for in vivo imaging.

Zhang C, Liu T, Su Y, Luo S, Zhu Y, Tan X, Fan S, Zhang L, Zhou Y, Cheng T, Shi C.

Biomaterials. 2010 Sep;31(25):6612-7. doi: 10.1016/j.biomaterials.2010.05.007. Epub 2010 Jun 9.

PMID:
20542559
[PubMed - indexed for MEDLINE]

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