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Similar articles for PubMed (Select 22234187)


Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype.

Davidson MB, Katou Y, Keszthelyi A, Sing TL, Xia T, Ou J, Vaisica JA, Thevakumaran N, Marjavaara L, Myers CL, Chabes A, Shirahige K, Brown GW.

EMBO J. 2012 Feb 15;31(4):895-907. doi: 10.1038/emboj.2011.485. Epub 2012 Jan 10.


dNTP pools determine fork progression and origin usage under replication stress.

Poli J, Tsaponina O, Crabbé L, Keszthelyi A, Pantesco V, Chabes A, Lengronne A, Pasero P.

EMBO J. 2012 Feb 15;31(4):883-94. doi: 10.1038/emboj.2011.470. Epub 2012 Jan 10.


Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase.

Chabes A, Georgieva B, Domkin V, Zhao X, Rothstein R, Thelander L.

Cell. 2003 Feb 7;112(3):391-401.


Ixr1 is required for the expression of the ribonucleotide reductase Rnr1 and maintenance of dNTP pools.

Tsaponina O, Barsoum E, Aström SU, Chabes A.

PLoS Genet. 2011 May;7(5):e1002061. doi: 10.1371/journal.pgen.1002061. Epub 2011 May 5.


Loss of yeast peroxiredoxin Tsa1p induces genome instability through activation of the DNA damage checkpoint and elevation of dNTP levels.

Tang HM, Siu KL, Wong CM, Jin DY.

PLoS Genet. 2009 Oct;5(10):e1000697. doi: 10.1371/journal.pgen.1000697. Epub 2009 Oct 23.


Elevated dNTP levels suppress hyper-recombination in Saccharomyces cerevisiae S-phase checkpoint mutants.

Fasullo M, Tsaponina O, Sun M, Chabes A.

Nucleic Acids Res. 2010 Mar;38(4):1195-203. doi: 10.1093/nar/gkp1064. Epub 2009 Dec 3.


Hydroxyurea arrests DNA replication by a mechanism that preserves basal dNTP pools.

Koç A, Wheeler LJ, Mathews CK, Merrill GF.

J Biol Chem. 2004 Jan 2;279(1):223-30. Epub 2003 Oct 21.


Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells.

Håkansson P, Hofer A, Thelander L.

J Biol Chem. 2006 Mar 24;281(12):7834-41. Epub 2006 Jan 24.


Elg1 forms an alternative RFC complex important for DNA replication and genome integrity.

Bellaoui M, Chang M, Ou J, Xu H, Boone C, Brown GW.

EMBO J. 2003 Aug 15;22(16):4304-13.


Mcm2 phosphorylation and the response to replicative stress.

Stead BE, Brandl CJ, Sandre MK, Davey MJ.

BMC Genet. 2012 May 7;13:36. doi: 10.1186/1471-2156-13-36.


Checkpoint deficient rad53-11 yeast cannot accumulate dNTPs in response to DNA damage.

Koc A, Merrill GF.

Biochem Biophys Res Commun. 2007 Feb 9;353(2):527-30. Epub 2006 Dec 18.


Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint.

Kumar D, Viberg J, Nilsson AK, Chabes A.

Nucleic Acids Res. 2010 Jul;38(12):3975-83. doi: 10.1093/nar/gkq128. Epub 2010 Mar 9.


dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants.

Williams LN, Marjavaara L, Knowels GM, Schultz EM, Fox EJ, Chabes A, Herr AJ.

Proc Natl Acad Sci U S A. 2015 Mar 31. pii: 201422948. [Epub ahead of print]


Genetic and physical interactions between the yeast ELG1 gene and orthologs of the Fanconi anemia pathway.

Singh S, Shemesh K, Liefshitz B, Kupiec M.

Cell Cycle. 2013 May 15;12(10):1625-36. doi: 10.4161/cc.24756. Epub 2013 Apr 25.


Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability.

Kanellis P, Agyei R, Durocher D.

Curr Biol. 2003 Sep 16;13(18):1583-95.


Spd1 accumulation causes genome instability independently of ribonucleotide reductase activity but functions to protect the genome when deoxynucleotide pools are elevated.

Fleck O, Vejrup-Hansen R, Watson A, Carr AM, Nielsen O, Holmberg C.

J Cell Sci. 2013 Nov 1;126(Pt 21):4985-94. doi: 10.1242/jcs.132837. Epub 2013 Aug 28.


The Elg1 replication factor C-like complex functions in PCNA unloading during DNA replication.

Kubota T, Nishimura K, Kanemaki MT, Donaldson AD.

Mol Cell. 2013 Apr 25;50(2):273-80. doi: 10.1016/j.molcel.2013.02.012. Epub 2013 Mar 14.

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