Format
Sort by

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 101

1.

Configuration of a high-content imaging platform for hit identification and pharmacological assessment of JMJD3 demethylase enzyme inhibitors.

Mulji A, Haslam C, Brown F, Randle R, Karamshi B, Smith J, Eagle R, Munoz-Muriedas J, Taylor J, Sheikh A, Bridges A, Gill K, Jepras R, Smee P, Barker M, Woodrow M, Liddle J, Thomas P, Jones E, Gordon L, Tanner R, Leveridge M, Hutchinson S, Martin M, Brown M, Kruidenier L, Katso R.

J Biomol Screen. 2012 Jan;17(1):108-20. doi: 10.1177/1087057111418229.

PMID:
22223398
2.

JMJD3 is a histone H3K27 demethylase.

Xiang Y, Zhu Z, Han G, Lin H, Xu L, Chen CD.

Cell Res. 2007 Oct;17(10):850-7.

3.

High-throughput TR-FRET assays for identifying inhibitors of LSD1 and JMJD2C histone lysine demethylases.

Yu V, Fisch T, Long AM, Tang J, Lee JH, Hierl M, Chen H, Yakowec P, Schwandner R, Emkey R.

J Biomol Screen. 2012 Jan;17(1):27-38. doi: 10.1177/1087057111418228. Epub 2011 Aug 21.

PMID:
21859682
4.

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.

Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, Bantscheff M, Bountra C, Bridges A, Diallo H, Eberhard D, Hutchinson S, Jones E, Katso R, Leveridge M, Mander PK, Mosley J, Ramirez-Molina C, Rowland P, Schofield CJ, Sheppard RJ, Smith JE, Swales C, Tanner R, Thomas P, Tumber A, Drewes G, Oppermann U, Patel DJ, Lee K, Wilson DM.

Nature. 2012 Aug 16;488(7411):404-8. doi: 10.1038/nature11262.

5.

Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.

King ON, Li XS, Sakurai M, Kawamura A, Rose NR, Ng SS, Quinn AM, Rai G, Mott BT, Beswick P, Klose RJ, Oppermann U, Jadhav A, Heightman TD, Maloney DJ, Schofield CJ, Simeonov A.

PLoS One. 2010 Nov 23;5(11):e15535. doi: 10.1371/journal.pone.0015535.

6.

The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation.

Chen S, Ma J, Wu F, Xiong LJ, Ma H, Xu W, Lv R, Li X, Villen J, Gygi SP, Liu XS, Shi Y.

Genes Dev. 2012 Jun 15;26(12):1364-75. doi: 10.1101/gad.186056.111.

7.

Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen.

Sayegh J, Cao J, Zou MR, Morales A, Blair LP, Norcia M, Hoyer D, Tackett AJ, Merkel JS, Yan Q.

J Biol Chem. 2013 Mar 29;288(13):9408-17. doi: 10.1074/jbc.M112.419861. Epub 2013 Feb 13.

8.

Enabling lead discovery for histone lysine demethylases by high-throughput RapidFire mass spectrometry.

Hutchinson SE, Leveridge MV, Heathcote ML, Francis P, Williams L, Gee M, Munoz-Muriedas J, Leavens B, Shillings A, Jones E, Homes P, Baddeley S, Chung CW, Bridges A, Argyrou A.

J Biomol Screen. 2012 Jan;17(1):39-48. doi: 10.1177/1087057111416660. Epub 2011 Aug 21.

PMID:
21859681
9.

Novel Scaffolds of Cell-Active Histone Demethylase Inhibitors Identified from High-Throughput Screening.

Wang W, Marholz LJ, Wang X.

J Biomol Screen. 2015 Jul;20(6):821-7. doi: 10.1177/1087057115579637. Epub 2015 Apr 16.

10.

The localization of histone H3K27me3 demethylase Jmjd3 is dynamically regulated.

Kamikawa YF, Donohoe ME.

Epigenetics. 2014 Jun;9(6):834-41. doi: 10.4161/epi.28524. Epub 2014 Mar 19.

11.

Jmjd3 contributes to the control of gene expression in LPS-activated macrophages.

De Santa F, Narang V, Yap ZH, Tusi BK, Burgold T, Austenaa L, Bucci G, Caganova M, Notarbartolo S, Casola S, Testa G, Sung WK, Wei CL, Natoli G.

EMBO J. 2009 Nov 4;28(21):3341-52. doi: 10.1038/emboj.2009.271. Epub 2009 Sep 24.

12.

Jmjd3-mediated epigenetic regulation of inflammatory cytokine gene expression in serum amyloid A-stimulated macrophages.

Yan Q, Sun L, Zhu Z, Wang L, Li S, Ye RD.

Cell Signal. 2014 Sep;26(9):1783-91. doi: 10.1016/j.cellsig.2014.03.025. Epub 2014 Apr 1.

13.

Jmjd3 activates Mash1 gene in RA-induced neuronal differentiation of P19 cells.

Dai JP, Lu JY, Zhang Y, Shen YF.

J Cell Biochem. 2010 Aug 15;110(6):1457-63. doi: 10.1002/jcb.22703.

PMID:
20506217
14.

TR-FRET cellular assays for interrogating posttranslational modifications of histone H3.

Machleidt T, Robers MB, Hermanson SB, Dudek JM, Bi K.

J Biomol Screen. 2011 Dec;16(10):1236-46. doi: 10.1177/1087057111422943. Epub 2011 Oct 4.

PMID:
21972037
15.

Inhibitor scaffold for the histone lysine demethylase KDM4C (JMJD2C).

Leurs U, Clausen RP, Kristensen JL, Lohse B.

Bioorg Med Chem Lett. 2012 Sep 15;22(18):5811-3. doi: 10.1016/j.bmcl.2012.07.091. Epub 2012 Aug 2.

PMID:
22917519
16.

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives.

Westaway SM, Preston AG, Barker MD, Brown F, Brown JA, Campbell M, Chung CW, Diallo H, Douault C, Drewes G, Eagle R, Gordon L, Haslam C, Hayhow TG, Humphreys PG, Joberty G, Katso R, Kruidenier L, Leveridge M, Liddle J, Mosley J, Muelbaier M, Randle R, Rioja I, Rueger A, Seal GA, Sheppard RJ, Singh O, Taylor J, Thomas P, Thomson D, Wilson DM, Lee K, Prinjha RK.

J Med Chem. 2016 Feb 25;59(4):1357-69. doi: 10.1021/acs.jmedchem.5b01537. Epub 2016 Jan 15.

PMID:
26771107
17.

The histone lysine demethylase JMJD3/KDM6B is recruited to p53 bound promoters and enhancer elements in a p53 dependent manner.

Williams K, Christensen J, Rappsilber J, Nielsen AL, Johansen JV, Helin K.

PLoS One. 2014 May 5;9(5):e96545. doi: 10.1371/journal.pone.0096545. eCollection 2014.

18.

Inhibited expression of hematopoietic progenitor kinase 1 associated with loss of jumonji domain containing 3 promoter binding contributes to autoimmunity in systemic lupus erythematosus.

Zhang Q, Long H, Liao J, Zhao M, Liang G, Wu X, Zhang P, Ding S, Luo S, Lu Q.

J Autoimmun. 2011 Nov;37(3):180-9. doi: 10.1016/j.jaut.2011.09.006. Epub 2011 Oct 19.

PMID:
22014533
19.

The H3K27 demethylase JMJD3 is required for maintenance of the embryonic respiratory neuronal network, neonatal breathing, and survival.

Burgold T, Voituron N, Caganova M, Tripathi PP, Menuet C, Tusi BK, Spreafico F, Bévengut M, Gestreau C, Buontempo S, Simeone A, Kruidenier L, Natoli G, Casola S, Hilaire G, Testa G.

Cell Rep. 2012 Nov 29;2(5):1244-58. doi: 10.1016/j.celrep.2012.09.013. Epub 2012 Oct 25.

20.

KDM6B/JMJD3 histone demethylase is induced by vitamin D and modulates its effects in colon cancer cells.

Pereira F, Barbáchano A, Silva J, Bonilla F, Campbell MJ, Muñoz A, Larriba MJ.

Hum Mol Genet. 2011 Dec 1;20(23):4655-65. doi: 10.1093/hmg/ddr399. Epub 2011 Sep 2.

Items per page

Supplemental Content

Write to the Help Desk