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Results: 1 to 20 of 113

1.

Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities.

Annedi SC, Ramnauth J, Maddaford SP, Renton P, Rakhit S, Mladenova G, Dove P, Silverman S, Andrews JS, Felice MD, Porreca F.

J Med Chem. 2012 Jan 26;55(2):943-55. doi: 10.1021/jm201564u. Epub 2012 Jan 10.

PMID:
22175766
[PubMed - indexed for MEDLINE]
2.

First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain.

Mladenova G, Annedi SC, Ramnauth J, Maddaford SP, Rakhit S, Andrews JS, Zhang D, Porreca F.

J Med Chem. 2012 Apr 12;55(7):3488-501. doi: 10.1021/jm300138g. Epub 2012 Apr 4.

PMID:
22420844
[PubMed - indexed for MEDLINE]
3.

Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain.

Annedi SC, Maddaford SP, Mladenova G, Ramnauth J, Rakhit S, Andrews JS, Lee DK, Zhang D, Porreca F, Bunton D, Christie L.

J Med Chem. 2011 Oct 27;54(20):7408-16. doi: 10.1021/jm201063u. Epub 2011 Oct 5.

PMID:
21923116
[PubMed - indexed for MEDLINE]
4.

1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors: lead optimization studies resulting in the identification of N-(1-(2-(methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a preclinical development candidate.

Ramnauth J, Renton P, Dove P, Annedi SC, Speed J, Silverman S, Mladenova G, Maddaford SP, Zinghini S, Rakhit S, Andrews J, Lee DK, Zhang D, Porreca F.

J Med Chem. 2012 Mar 22;55(6):2882-93. doi: 10.1021/jm3000449. Epub 2012 Mar 1.

PMID:
22335555
[PubMed - indexed for MEDLINE]
5.

Discovery of a potent, orally bioavailable and highly selective human neuronal nitric oxide synthase (nNOS) inhibitor, N-(1-(piperidin-4-yl)indolin-5-yl)thiophene-2-carboximidamide as a pre-clinical development candidate for the treatment of migraine.

Annedi SC, Maddaford SP, Ramnauth J, Renton P, Rybak T, Silverman S, Rakhit S, Mladenova G, Dove P, Andrews JS, Zhang D, Porreca F.

Eur J Med Chem. 2012 Sep;55:94-107. doi: 10.1016/j.ejmech.2012.07.006. Epub 2012 Jul 14.

PMID:
22840695
[PubMed - indexed for MEDLINE]
6.

3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors.

Annedi SC, Maddaford SP, Ramnauth J, Renton P, Speed J, Rakhit S, Andrews JS, Porreca F.

Bioorg Med Chem Lett. 2012 Mar 1;22(5):1980-4. doi: 10.1016/j.bmcl.2012.01.031. Epub 2012 Jan 21.

PMID:
22318159
[PubMed - indexed for MEDLINE]
7.

Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS).

Annedi SC, Ramnauth J, Cossette M, Maddaford SP, Dove P, Rakhit S, Andrews JS, Porreca F.

Bioorg Med Chem Lett. 2012 Apr 1;22(7):2510-3. doi: 10.1016/j.bmcl.2012.02.004. Epub 2012 Feb 9.

PMID:
22370270
[PubMed - indexed for MEDLINE]
8.

Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors.

Ramnauth J, Speed J, Maddaford SP, Dove P, Annedi SC, Renton P, Rakhit S, Andrews J, Silverman S, Mladenova G, Zinghini S, Nair S, Catalano C, Lee DK, De Felice M, Porreca F.

J Med Chem. 2011 Aug 11;54(15):5562-75. doi: 10.1021/jm200648s. Epub 2011 Jul 8.

PMID:
21699209
[PubMed - indexed for MEDLINE]
9.

Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective series of benzimidazole-quinolinone iNOS/nNOS dimerization inhibitors that are orally active in pain models.

Payne JE, Bonnefous C, Symons KT, Nguyen PM, Sablad M, Rozenkrants N, Zhang Y, Wang L, Yazdani N, Shiau AK, Noble SA, Rix P, Rao TS, Hassig CA, Smith ND.

J Med Chem. 2010 Nov 11;53(21):7739-55. doi: 10.1021/jm100828n.

PMID:
20931971
[PubMed - indexed for MEDLINE]
10.

Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase.

Hah JM, Martásek P, Roman LJ, Silverman RB.

J Med Chem. 2003 Apr 24;46(9):1661-9.

PMID:
12699384
[PubMed - indexed for MEDLINE]
11.

Potent and selective double-headed thiophene-2-carboximidamide inhibitors of neuronal nitric oxide synthase for the treatment of melanoma.

Huang H, Li H, Yang S, Chreifi G, Martásek P, Roman LJ, Meyskens FL, Poulos TL, Silverman RB.

J Med Chem. 2014 Feb 13;57(3):686-700. doi: 10.1021/jm401252e. Epub 2014 Jan 30.

PMID:
24447275
[PubMed - indexed for MEDLINE]
12.

Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase.

Hah JM, Roman LJ, Martásek P, Silverman RB.

J Med Chem. 2001 Aug 2;44(16):2667-70.

PMID:
11472219
[PubMed - indexed for MEDLINE]
13.

Pharmacological characterization of KLYP961, a dual inhibitor of inducible and neuronal nitric-oxide synthases.

Symons KT, Nguyen PM, Massari ME, Anzola JV, Staszewski LM, Wang L, Yazdani N, Dorow S, Muhammad J, Sablad M, Rozenkrants N, Bonefous C, Payne JE, Rix PJ, Shiau AK, Noble SA, Smith ND, Hassig CA, Zhang Y, Rao TS.

J Pharmacol Exp Ther. 2011 Feb;336(2):468-78. doi: 10.1124/jpet.110.172817. Epub 2010 Oct 29.

PMID:
21036913
[PubMed - indexed for MEDLINE]
Free Article
14.

1,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors.

Renton P, Speed J, Maddaford S, Annedi SC, Ramnauth J, Rakhit S, Andrews J.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5301-4. doi: 10.1016/j.bmcl.2011.07.022. Epub 2011 Jul 14.

PMID:
21813276
[PubMed - indexed for MEDLINE]
15.

Potent and selective conformationally restricted neuronal nitric oxide synthase inhibitors.

Gómez-Vidal JA, Martásek P, Roman LJ, Silverman RB.

J Med Chem. 2004 Jan 29;47(3):703-10.

PMID:
14736250
[PubMed - indexed for MEDLINE]
16.

Role of neuronal nitric-oxide synthase in estrogen-induced relaxation in rat resistance arteries.

Lekontseva O, Chakrabarti S, Jiang Y, Cheung CC, Davidge ST.

J Pharmacol Exp Ther. 2011 Nov;339(2):367-75. doi: 10.1124/jpet.111.183798. Epub 2011 Aug 1.

PMID:
21807885
[PubMed - indexed for MEDLINE]
Free Article
17.

1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors.

Maddaford S, Renton P, Speed J, Annedi SC, Ramnauth J, Rakhit S, Andrews J, Mladenova G, Majuta L, Porreca F.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5234-8. doi: 10.1016/j.bmcl.2011.07.042. Epub 2011 Jul 22.

PMID:
21824773
[PubMed - indexed for MEDLINE]
18.

Endothelial nitric oxide synthase is predominantly involved in angiotensin II modulation of renal vascular resistance and norepinephrine release.

Stegbauer J, Kuczka Y, Vonend O, Quack I, Sellin L, Patzak A, Steege A, Langnaese K, Rump LC.

Am J Physiol Regul Integr Comp Physiol. 2008 Feb;294(2):R421-8. Epub 2007 Nov 28.

PMID:
18046021
[PubMed - indexed for MEDLINE]
19.

Pharmacological assessments of nitric oxide synthase isoforms and downstream diversity of NO signaling in the maintenance of thermal and mechanical hypersensitivity after peripheral nerve injury in mice.

Tanabe M, Nagatani Y, Saitoh K, Takasu K, Ono H.

Neuropharmacology. 2009 Mar;56(3):702-8. doi: 10.1016/j.neuropharm.2008.12.003. Epub 2008 Dec 16.

PMID:
19111753
[PubMed - indexed for MEDLINE]
20.

Nitric oxide synthase isoform inhibition before whole body ischemia reperfusion in pigs: vital or protective?

Adams JA, Wu D, Bassuk J, Arias J, Lozano H, Kurlansky P, Lamas GA.

Resuscitation. 2007 Sep;74(3):516-25. Epub 2007 Apr 26.

PMID:
17466432
[PubMed - indexed for MEDLINE]

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