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A palmitoylation switch mechanism regulates Rac1 function and membrane organization.

Navarro-Lérida I, Sánchez-Perales S, Calvo M, Rentero C, Zheng Y, Enrich C, Del Pozo MA.

EMBO J. 2012 Feb 1;31(3):534-51. doi: 10.1038/emboj.2011.446. Epub 2011 Dec 9.


Phospholipase D activity regulates integrin-mediated cell spreading and migration by inducing GTP-Rac translocation to the plasma membrane.

Chae YC, Kim JH, Kim KL, Kim HW, Lee HY, Heo WD, Meyer T, Suh PG, Ryu SH.

Mol Biol Cell. 2008 Jul;19(7):3111-23. doi: 10.1091/mbc.E07-04-0337. Epub 2008 May 14.


Palmitoylation regulates regulators of G-protein signaling (RGS) 16 function. I. Mutation of amino-terminal cysteine residues on RGS16 prevents its targeting to lipid rafts and palmitoylation of an internal cysteine residue.

Hiol A, Davey PC, Osterhout JL, Waheed AA, Fischer ER, Chen CK, Milligan G, Druey KM, Jones TL.

J Biol Chem. 2003 May 23;278(21):19301-8. Epub 2003 Mar 17.


Role of palmitoylation in RGS protein function.

Jones TL.

Methods Enzymol. 2004;389:33-55. Review.


A non-farnesylated Ha-Ras protein can be palmitoylated and trigger potent differentiation and transformation.

Booden MA, Baker TL, Solski PA, Der CJ, Punke SG, Buss JE.

J Biol Chem. 1999 Jan 15;274(3):1423-31.


Interaction with Gbetagamma is required for membrane targeting and palmitoylation of Galpha(s) and Galpha(q).

Evanko DS, Thiyagarajan MM, Wedegaertner PB.

J Biol Chem. 2000 Jan 14;275(2):1327-36.


Mechanism of NADPH oxidase activation by the Rac/Rho-GDI complex.

Di-Poï N, Fauré J, Grizot S, Molnár G, Pick E, Dagher MC.

Biochemistry. 2001 Aug 28;40(34):10014-22.


N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localization.

Cadwallader KA, Paterson H, Macdonald SG, Hancock JF.

Mol Cell Biol. 1994 Jul;14(7):4722-30.


Cell migration and signaling specificity is determined by the phosphatidylserine recognition motif of Rac1.

Finkielstein CV, Overduin M, Capelluto DG.

J Biol Chem. 2006 Sep 15;281(37):27317-26. Epub 2006 Jul 21.


MYADM regulates Rac1 targeting to ordered membranes required for cell spreading and migration.

Aranda JF, Reglero-Real N, Kremer L, Marcos-Ramiro B, Ruiz-Sáenz A, Calvo M, Enrich C, Correas I, Millán J, Alonso MA.

Mol Biol Cell. 2011 Apr 15;22(8):1252-62. doi: 10.1091/mbc.E10-11-0910. Epub 2011 Feb 16.


Crystal structure of the Rac1-RhoGDI complex involved in nadph oxidase activation.

Grizot S, Fauré J, Fieschi F, Vignais PV, Dagher MC, Pebay-Peyroula E.

Biochemistry. 2001 Aug 28;40(34):10007-13.


Transforming activity of the Rho family GTPase, Wrch-1, a Wnt-regulated Cdc42 homolog, is dependent on a novel carboxyl-terminal palmitoylation motif.

Berzat AC, Buss JE, Chenette EJ, Weinbaum CA, Shutes A, Der CJ, Minden A, Cox AD.

J Biol Chem. 2005 Sep 23;280(38):33055-65. Epub 2005 Jul 26.


Post-translational processing of rac p21s is important both for their interaction with the GDP/GTP exchange proteins and for their activation of NADPH oxidase.

Ando S, Kaibuchi K, Sasaki T, Hiraoka K, Nishiyama T, Mizuno T, Asada M, Nunoi H, Matsuda I, Matsuura Y, et al.

J Biol Chem. 1992 Dec 25;267(36):25709-13.


The role of palmitoylation of the guanine nucleotide binding protein G11 alpha in defining interaction with the plasma membrane.

McCallum JF, Wise A, Grassie MA, Magee AI, Guzzi F, Parenti M, Milligan G.

Biochem J. 1995 Sep 15;310 ( Pt 3):1021-7.


GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits.

De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG.

Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15203-8.


Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division.

Michaelson D, Abidi W, Guardavaccaro D, Zhou M, Ahearn I, Pagano M, Philips MR.

J Cell Biol. 2008 May 5;181(3):485-96. doi: 10.1083/jcb.200801047. Epub 2008 Apr 28.

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