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Rationale and design of the B-PROOF study, a randomized controlled trial on the effect of supplemental intake of vitamin B12 and folic acid on fracture incidence.

van Wijngaarden JP, Dhonukshe-Rutten RA, van Schoor NM, van der Velde N, Swart KM, Enneman AW, van Dijk SC, Brouwer-Brolsma EM, Zillikens MC, van Meurs JB, Brug J, Uitterlinden AG, Lips P, de Groot LC.

BMC Geriatr. 2011 Dec 2;11:80. doi: 10.1186/1471-2318-11-80.


Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial.

van Wijngaarden JP, Swart KM, Enneman AW, Dhonukshe-Rutten RA, van Dijk SC, Ham AC, Brouwer-Brolsma EM, van der Zwaluw NL, Sohl E, van Meurs JB, Zillikens MC, van Schoor NM, van der Velde N, Brug J, Uitterlinden AG, Lips P, de Groot LC.

Am J Clin Nutr. 2014 Dec;100(6):1578-86. doi: 10.3945/ajcn.114.090043. Epub 2014 Oct 1.


Folic acid with or without vitamin B12 for cognition and dementia.

Malouf M, Grimley EJ, Areosa SA.

Cochrane Database Syst Rev. 2003;(4):CD004514. Review. Update in: Cochrane Database Syst Rev. 2008;(4):CD004514.


Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people.

Malouf R, Grimley Evans J.

Cochrane Database Syst Rev. 2008 Oct 8;(4):CD004514. doi: 10.1002/14651858.CD004514.pub2. Review.


Folic acid and vitamin B(12) supplementation lowers plasma homocysteine but has no effect on serum bone turnover markers in elderly women: a randomized, double-blind, placebo-controlled trial.

Keser I, Ilich JZ, Vrkić N, Giljević Z, Colić Barić I.

Nutr Res. 2013 Mar;33(3):211-9. doi: 10.1016/j.nutres.2013.01.002. Epub 2013 Feb 1.


Vitamin B12, folic acid, and bone.

Swart KM, van Schoor NM, Lips P.

Curr Osteoporos Rep. 2013 Sep;11(3):213-8. doi: 10.1007/s11914-013-0155-2. Review.


Rationale, design and baseline characteristics of a large, simple, randomized trial of combined folic acid and vitamins B6 and B12 in high-risk patients: the Heart Outcomes Prevention Evaluation (HOPE)-2 trial.

Lonn E, Held C, Arnold JM, Probstfield J, McQueen M, Micks M, Pogue J, Sheridan P, Bosch J, Genest J, Yusuf S; HOPE-2 Investigators.

Can J Cardiol. 2006 Jan;22(1):47-53.


Effectiveness and safety of vitamin D in relation to bone health.

Cranney A, Horsley T, O'Donnell S, Weiler H, Puil L, Ooi D, Atkinson S, Ward L, Moher D, Hanley D, Fang M, Yazdi F, Garritty C, Sampson M, Barrowman N, Tsertsvadze A, Mamaladze V.

Evid Rep Technol Assess (Full Rep). 2007 Aug;(158):1-235. Review.


Prevention of falls and fractures in old people by administration of calcium and vitamin D, randomized clinical trial.

López-Torres Hidalgo J; ANVITAD Group.

BMC Public Health. 2011 Dec 9;11:910. doi: 10.1186/1471-2458-11-910.


Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial.

Albert CM, Cook NR, Gaziano JM, Zaharris E, MacFadyen J, Danielson E, Buring JE, Manson JE.

JAMA. 2008 May 7;299(17):2027-36. doi: 10.1001/jama.299.17.2027.


The B-VITAGE trial: a randomized trial of homocysteine lowering treatment of depression in later life.

Ford AH, Flicker L, McCaul K, van Bockxmeer F, Hegarty S, Hirani V, Fenner S, Almeida OP.

Trials. 2010 Jan 25;11:8. doi: 10.1186/1745-6215-11-8. Erratum in: Trials. 2011;12:193.


Homocysteine and vitamin B12 status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people.

Dhonukshe-Rutten RA, Pluijm SM, de Groot LC, Lips P, Smit JH, van Staveren WA.

J Bone Miner Res. 2005 Jun;20(6):921-9. Epub 2005 Feb 7.


Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial.

Eussen SJ, de Groot LC, Joosten LW, Bloo RJ, Clarke R, Ueland PM, Schneede J, Blom HJ, Hoefnagels WH, van Staveren WA.

Am J Clin Nutr. 2006 Aug;84(2):361-70.


The effect of long-term homocysteine-lowering on carotid intima-media thickness and flow-mediated vasodilation in stroke patients: a randomized controlled trial and meta-analysis.

Potter K, Hankey GJ, Green DJ, Eikelboom J, Jamrozik K, Arnolda LF.

BMC Cardiovasc Disord. 2008 Sep 20;8:24. doi: 10.1186/1471-2261-8-24. Review.


The effect of homocysteine-lowering with B-vitamins on osteoporotic fractures in patients with cerebrovascular disease: substudy of VITATOPS, a randomised placebo-controlled trial.

Gommans J, Yi Q, Eikelboom JW, Hankey GJ, Chen C, Rodgers H; VITATOPS trial study group.

BMC Geriatr. 2013 Sep 3;13:88. doi: 10.1186/1471-2318-13-88.


Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults.

Fenech M, Aitken C, Rinaldi J.

Carcinogenesis. 1998 Jul;19(7):1163-71.

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