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Targeting radioresistant osteosarcoma cells with parthenolide.

Zuch D, Giang AH, Shapovalov Y, Schwarz E, Rosier R, O'Keefe R, Eliseev RA.

J Cell Biochem. 2012 Apr;113(4):1282-91. doi: 10.1002/jcb.24002.


Suppression of NF-kappaB activity by parthenolide induces X-ray sensitivity through inhibition of split-dose repair in TP53 null prostate cancer cells.

Watson C, Miller DA, Chin-Sinex H, Losch A, Hughes W, Sweeney C, Mendonca MS.

Radiat Res. 2009 Apr;171(4):389-96. doi: 10.1667/RR1394.1.


Therapeutic implications of an enriched cancer stem-like cell population in a human osteosarcoma cell line.

Martins-Neves SR, Lopes ÁO, do Carmo A, Paiva AA, Simões PC, Abrunhosa AJ, Gomes CM.

BMC Cancer. 2012 Apr 4;12:139. doi: 10.1186/1471-2407-12-139.


Parthenolide induces caspase-independent and AIF-mediated cell death in human osteosarcoma and melanoma cells.

D'Anneo A, Carlisi D, Lauricella M, Emanuele S, Di Fiore R, Vento R, Tesoriere G.

J Cell Physiol. 2013 May;228(5):952-67. doi: 10.1002/jcp.24131.


Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-kappa B pathway in pancreatic carcinoma cells.

Yip-Schneider MT, Nakshatri H, Sweeney CJ, Marshall MS, Wiebke EA, Schmidt CM.

Mol Cancer Ther. 2005 Apr;4(4):587-94.


Sesquiterpene lactone parthenolide suppresses tumor growth in a xenograft model of renal cell carcinoma by inhibiting the activation of NF-kappaB.

Oka D, Nishimura K, Shiba M, Nakai Y, Arai Y, Nakayama M, Takayama H, Inoue H, Okuyama A, Nonomura N.

Int J Cancer. 2007 Jun 15;120(12):2576-81.


Proteasome inhibition improves fractionated radiation treatment against non-small cell lung cancer: an antioxidant connection.

Grimes KR, Daosukho C, Zhao Y, Meigooni A, St Clair W.

Int J Oncol. 2005 Oct;27(4):1047-52.


Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer.

De Bacco F, Luraghi P, Medico E, Reato G, Girolami F, Perera T, Gabriele P, Comoglio PM, Boccaccio C.

J Natl Cancer Inst. 2011 Apr 20;103(8):645-61. doi: 10.1093/jnci/djr093. Epub 2011 Apr 4.


Parthenolide sensitizes cells to X-ray-induced cell killing through inhibition of NF-kappaB and split-dose repair.

Mendonca MS, Chin-Sinex H, Gomez-Millan J, Datzman N, Hardacre M, Comerford K, Nakshatri H, Nye M, Benjamin L, Mehta S, Patino F, Sweeney C.

Radiat Res. 2007 Dec;168(6):689-97.


Glycogen synthase kinase-3β, NF-κB signaling, and tumorigenesis of human osteosarcoma.

Tang QL, Xie XB, Wang J, Chen Q, Han AJ, Zou CY, Yin JQ, Liu DW, Liang Y, Zhao ZQ, Yong BC, Zhang RH, Feng QS, Deng WG, Zhu XF, Zhou BP, Zeng YX, Shen JN, Kang T.

J Natl Cancer Inst. 2012 May 16;104(10):749-63. doi: 10.1093/jnci/djs210. Epub 2012 Apr 24.


Vitamin K2-derived compounds induce growth inhibition in radioresistant cancer cells.

Amalia H, Sasaki R, Suzuki Y, Demizu Y, Bito T, Nishimura H, Okamoto Y, Yoshida K, Miyawaki D, Kawabe T, Mizushina Y, Sugimura K.

Kobe J Med Sci. 2010 Sep 28;56(2):E38-49.


Perspectives on cancer stem cells in osteosarcoma.

Basu-Roy U, Basilico C, Mansukhani A.

Cancer Lett. 2013 Sep 10;338(1):158-67. doi: 10.1016/j.canlet.2012.05.028. Epub 2012 May 29. Review.


Parthenolide reduces the frequency of ABCB5-positive cells and clonogenic capacity of melanoma cells from anchorage independent melanospheres.

Czyz M, Koprowska K, Sztiller-Sikorska M.

Cancer Biol Ther. 2013 Feb;14(2):135-45. doi: 10.4161/cbt.22952. Epub 2012 Nov 28.


NF-kappa B-mediated adaptive resistance to ionizing radiation.

Ahmed KM, Li JJ.

Free Radic Biol Med. 2008 Jan 1;44(1):1-13. Epub 2007 Oct 10. Review.


The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells.

Guzman ML, Rossi RM, Karnischky L, Li X, Peterson DR, Howard DS, Jordan CT.

Blood. 2005 Jun 1;105(11):4163-9. Epub 2005 Feb 1.


Sesquiterpene lactone parthenolide markedly enhances sensitivity of human A549 cells to low-dose oxaliplatin via inhibition of NF-kappaB activation and induction of apoptosis.

Fang LJ, Shao XT, Wang S, Lu GH, Xu T, Zhou JY.

Planta Med. 2010 Feb;76(3):258-64. doi: 10.1055/s-0029-1186083. Epub 2009 Sep 11.


Salinomycin inhibits osteosarcoma by targeting its tumor stem cells.

Tang QL, Zhao ZQ, Li JC, Liang Y, Yin JQ, Zou CY, Xie XB, Zeng YX, Shen JN, Kang T, Wang J.

Cancer Lett. 2011 Dec 1;311(1):113-21. doi: 10.1016/j.canlet.2011.07.016. Epub 2011 Jul 21.


Parthenolide cooperates with NS398 to inhibit growth of human hepatocellular carcinoma cells through effects on apoptosis and G0-G1 cell cycle arrest.

Ralstin MC, Gage EA, Yip-Schneider MT, Klein PJ, Wiebke EA, Schmidt CM.

Mol Cancer Res. 2006 Jun;4(6):387-99.


Biological activity of dihydroartemisinin in canine osteosarcoma cell lines.

Hosoya K, Murahari S, Laio A, London CA, Couto CG, Kisseberth WC.

Am J Vet Res. 2008 Apr;69(4):519-26. doi: 10.2460/ajvr.69.4.519.

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