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Items: 1 to 20 of 104

1.

An intermediate-risk multiple myeloma subgroup is defined by sIL-6r: levels synergistically increase with incidence of SNP rs2228145 and 1q21 amplification.

Stephens OW, Zhang Q, Qu P, Zhou Y, Chavan S, Tian E, Williams DR, Epstein J, Barlogie B, Shaughnessy JD Jr.

Blood. 2012 Jan 12;119(2):503-12. doi: 10.1182/blood-2011-07-367052. Epub 2011 Nov 9.

2.

The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases.

Garbers C, Monhasery N, Aparicio-Siegmund S, Lokau J, Baran P, Nowell MA, Jones SA, Rose-John S, Scheller J.

Biochim Biophys Acta. 2014 Sep;1842(9):1485-94. doi: 10.1016/j.bbadis.2014.05.018. Epub 2014 May 27.

3.

Increased copy number of the interleukin-6 receptor gene is associated with adverse survival in multiple myeloma patients treated with autologous stem cell transplantation.

Kim SY, Min HJ, Park HK, Oh B, Kim TY, She CJ, Hwang SM, Kim M, Kim HK, Kim I, Yoon SS, Park S, Kim BK, Lee JH, Lee DS; Korea Multiple Myeloma Working Party.

Biol Blood Marrow Transplant. 2011 Jun;17(6):810-20. doi: 10.1016/j.bbmt.2011.01.002. Epub 2011 Jan 8.

4.

Association of plasma IL-6 and soluble IL-6 receptor levels with the Asp358Ala polymorphism of the IL-6 receptor gene in schizophrenic patients.

Sasayama D, Wakabayashi C, Hori H, Teraishi T, Hattori K, Ota M, Ishikawa M, Arima K, Higuchi T, Amano N, Kunugi H.

J Psychiatr Res. 2011 Nov;45(11):1439-44. doi: 10.1016/j.jpsychires.2011.06.003. Epub 2011 Jun 22.

PMID:
21700295
5.

Polymorphisms in the IL-6 receptor (IL-6R) gene: strong evidence that serum levels of soluble IL-6R are genetically influenced.

Galicia JC, Tai H, Komatsu Y, Shimada Y, Akazawa K, Yoshie H.

Genes Immun. 2004 Sep;5(6):513-6.

PMID:
15306846
6.

Alternative splicing and proteolytic rupture contribute to the generation of soluble IL-6 receptors (sIL-6R) in rheumatoid arthritis.

Lamas JR, Rodríguez-Rodríguez L, Tornero-Esteban P, Villafuertes E, Hoyas J, Abasolo L, Varadé J, Alvarez-Lafuente R, Urcelay E, Fernández-Gutiérrez B.

Cytokine. 2013 Mar;61(3):720-3. doi: 10.1016/j.cyto.2012.12.025. Epub 2013 Jan 29.

PMID:
23375120
7.

Soluble interleukin-6 receptor (sIL-6R), a new prognostic factor in multiple myeloma.

Kyrtsonis MC, Dedoussis G, Zervas C, Perifanis V, Baxevanis C, Stamatelou M, Maniatis A.

Br J Haematol. 1996 May;93(2):398-400.

PMID:
8639436
8.

Soluble interleukin-6 receptor as a prognostic factor in multiple myeloma. Finnish Leukaemia Group.

Pulkki K, Pelliniemi TT, Rajamäki A, Tienhaara A, Laakso M, Lahtinen R.

Br J Haematol. 1996 Feb;92(2):370-4.

PMID:
8603002
9.

Serum levels of soluble IL-6 receptor in multiple myeloma as indicator of disease activity.

Papadaki H, Kyriakou D, Foudoulakis A, Markidou F, Alexandrakis M, Eliopoulos GD.

Acta Haematol. 1997;97(4):191-5.

PMID:
9158660
10.

The prognostic value of soluble interleukin-6 receptor in patients with multiple myeloma.

Stasi R, Brunetti M, Parma A, Di Giulio C, Terzoli E, Pagano A.

Cancer. 1998 May 15;82(10):1860-6.

PMID:
9587117
11.

A new regulatory variant in the interleukin-6 receptor gene associates with asthma risk.

Revez JA, Bain L, Chapman B, Powell JE, Jansen R, Duffy DL, Tung JY; AAGC Collaborators, Penninx BW, Visscher PM, De Geus EJ, Boomsma DI, Hinds DA, Martin NG, Montgomery GW, Ferreira MA.

Genes Immun. 2013 Oct;14(7):441-6. doi: 10.1038/gene.2013.38. Epub 2013 Aug 15.

12.

A gain of function polymorphism in the interleukin 6 receptor influences RA susceptibility.

Marinou I, Walters K, Winfield J, Bax DE, Wilson AG.

Ann Rheum Dis. 2010 Jun;69(6):1191-4. doi: 10.1136/ard.2008.100644. Epub 2009 Aug 26.

PMID:
19713205
13.

The contribution of the functional IL6R polymorphism rs2228145, eQTLs and other genome-wide SNPs to the heritability of plasma sIL-6R levels.

van Dongen J, Jansen R, Smit D, Hottenga JJ, Mbarek H, Willemsen G, Kluft C; AAGC Collaborators, Penninx BW, Ferreira MA, Boomsma DI, de Geus EJ.

Behav Genet. 2014 Jul;44(4):368-82. doi: 10.1007/s10519-014-9656-8. Epub 2014 May 3.

14.

Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases.

Ferreira RC, Freitag DF, Cutler AJ, Howson JM, Rainbow DB, Smyth DJ, Kaptoge S, Clarke P, Boreham C, Coulson RM, Pekalski ML, Chen WM, Onengut-Gumuscu S, Rich SS, Butterworth AS, Malarstig A, Danesh J, Todd JA.

PLoS Genet. 2013 Apr;9(4):e1003444. doi: 10.1371/journal.pgen.1003444. Epub 2013 Apr 4.

15.

Plasma soluble IL-6 receptor concentration in rheumatoid arthritis: associations with the rs8192284 IL6R polymorphism and with disease activity.

Rodríguez-Rodríguez L, Lamas JR, Varadé J, López-Romero P, Tornero-Esteban P, Abasolo L, de la Concha EG, Jover JA, Urcelay E, Fernández-Gutiérrez B.

Rheumatol Int. 2011 Mar;31(3):409-13. doi: 10.1007/s00296-010-1593-0. Epub 2010 Jul 27.

PMID:
20661738
16.

The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma.

Hawkins GA, Robinson MB, Hastie AT, Li X, Li H, Moore WC, Howard TD, Busse WW, Erzurum SC, Wenzel SE, Peters SP, Meyers DA, Bleecker ER; National Heart, Lung, and Blood Institute–sponsored Severe Asthma Research Program (SARP).

J Allergy Clin Immunol. 2012 Aug;130(2):510-5.e1. doi: 10.1016/j.jaci.2012.03.018. Epub 2012 May 1.

17.

Circulating IL-6-type cytokines and sIL-6R in patients with multiple myeloma.

Wierzbowska A, Urbańska-Ryś H, Robak T.

Br J Haematol. 1999 May;105(2):412-9.

PMID:
10233412
19.
20.

The relationship between soluble receptor of interleukin-6 with angiogenic cytokines and proliferation markers in multiple myeloma.

Tsirakis G, Pappa CA, Kaparou M, Boula A, Katsomitrou V, Xekalou A, Kyriakaki S, Alexandrakis MG.

Tumour Biol. 2013 Apr;34(2):859-64. doi: 10.1007/s13277-012-0618-6. Epub 2012 Dec 16.

PMID:
23242610
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