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Results: 1 to 20 of 132

1.

Cholera toxin: an intracellular journey into the cytosol by way of the endoplasmic reticulum.

Wernick NL, Chinnapen DJ, Cho JA, Lencer WI.

Toxins (Basel). 2010 Mar;2(3):310-25. doi: 10.3390/toxins2030310. Epub 2010 Mar 5. Review.

PMID:
22069586
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The intracellular voyage of cholera toxin: going retro.

Lencer WI, Tsai B.

Trends Biochem Sci. 2003 Dec;28(12):639-45. Review.

PMID:
14659695
[PubMed - indexed for MEDLINE]
3.

Insights on the trafficking and retro-translocation of glycosphingolipid-binding bacterial toxins.

Cho JA, Chinnapen DJ, Aamar E, te Welscher YM, Lencer WI, Massol R.

Front Cell Infect Microbiol. 2012 Apr 11;2:51. doi: 10.3389/fcimb.2012.00051. eCollection 2012. Review.

PMID:
22919642
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Rafting with cholera toxin: endocytosis and trafficking from plasma membrane to ER.

Chinnapen DJ, Chinnapen H, Saslowsky D, Lencer WI.

FEMS Microbiol Lett. 2007 Jan;266(2):129-37. Epub 2006 Nov 29. Review.

PMID:
17156122
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

A biochemical method for tracking cholera toxin transport from plasma membrane to Golgi and endoplasmic reticulum.

De Luca HE, Lencer WI.

Methods Mol Biol. 2006;341:127-39. Review.

PMID:
16799195
[PubMed - indexed for MEDLINE]
6.

N-terminal extension of the cholera toxin A1-chain causes rapid degradation after retrotranslocation from endoplasmic reticulum to cytosol.

Wernick NL, De Luca H, Kam WR, Lencer WI.

J Biol Chem. 2010 Feb 26;285(9):6145-52. doi: 10.1074/jbc.M109.062067. Epub 2010 Jan 7.

PMID:
20056601
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Trafficking of cholera toxin-ganglioside GM1 complex into Golgi and induction of toxicity depend on actin cytoskeleton.

Badizadegan K, Wheeler HE, Fujinaga Y, Lencer WI.

Am J Physiol Cell Physiol. 2004 Nov;287(5):C1453-62. Epub 2004 Aug 4.

PMID:
15294854
[PubMed - indexed for MEDLINE]
Free Article
8.

Lipid sorting by ceramide structure from plasma membrane to ER for the cholera toxin receptor ganglioside GM1.

Chinnapen DJ, Hsieh WT, te Welscher YM, Saslowsky DE, Kaoutzani L, Brandsma E, D'Auria L, Park H, Wagner JS, Drake KR, Kang M, Benjamin T, Ullman MD, Costello CE, Kenworthy AK, Baumgart T, Massol RH, Lencer WI.

Dev Cell. 2012 Sep 11;23(3):573-86. doi: 10.1016/j.devcel.2012.08.002.

PMID:
22975326
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Role of ubiquitination in retro-translocation of cholera toxin and escape of cytosolic degradation.

Rodighiero C, Tsai B, Rapoport TA, Lencer WI.

EMBO Rep. 2002 Dec;3(12):1222-7. Epub 2002 Nov 21.

PMID:
12446567
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Establishment of an in vitro transport assay that reveals mechanistic differences in cytosolic events controlling cholera toxin and T-cell receptor α retro-translocation.

Moore P, He K, Tsai B.

PLoS One. 2013 Oct 11;8(10):e75801. doi: 10.1371/journal.pone.0075801. eCollection 2013.

PMID:
24146777
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

A single native ganglioside GM1-binding site is sufficient for cholera toxin to bind to cells and complete the intoxication pathway.

Jobling MG, Yang Z, Kam WR, Lencer WI, Holmes RK.

MBio. 2012 Oct 30;3(6). pii: e00401-12. doi: 10.1128/mBio.00401-12.

PMID:
23111873
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Retrograde transport of cholera toxin into the ER of host cells.

Lencer WI.

Int J Med Microbiol. 2004 Apr;293(7-8):491-4. Review.

PMID:
15149023
[PubMed - indexed for MEDLINE]
13.

Derlin-1 facilitates the retro-translocation of cholera toxin.

Bernardi KM, Forster ML, Lencer WI, Tsai B.

Mol Biol Cell. 2008 Mar;19(3):877-84. Epub 2007 Dec 19.

PMID:
18094046
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Entry of protein toxins into mammalian cells by crossing the endoplasmic reticulum membrane: co-opting basic mechanisms of endoplasmic reticulum-associated degradation.

Lord JM, Roberts LM, Lencer WI.

Curr Top Microbiol Immunol. 2005;300:149-68. Review.

PMID:
16573240
[PubMed - indexed for MEDLINE]
16.

A therapeutic chemical chaperone inhibits cholera intoxication and unfolding/translocation of the cholera toxin A1 subunit.

Taylor M, Banerjee T, Navarro-Garcia F, Huerta J, Massey S, Burlingame M, Pande AH, Tatulian SA, Teter K.

PLoS One. 2011 Apr 19;6(4):e18825. doi: 10.1371/journal.pone.0018825.

PMID:
21526142
[PubMed - indexed for MEDLINE]
Free PMC Article
17.
18.

Raft trafficking of AB5 subunit bacterial toxins.

Lencer WI, Saslowsky D.

Biochim Biophys Acta. 2005 Dec 30;1746(3):314-21. Epub 2005 Aug 15. Review.

PMID:
16153723
[PubMed - indexed for MEDLINE]
Free Article
19.

Gangliosides that associate with lipid rafts mediate transport of cholera and related toxins from the plasma membrane to endoplasmic reticulm.

Fujinaga Y, Wolf AA, Rodighiero C, Wheeler H, Tsai B, Allen L, Jobling MG, Rapoport T, Holmes RK, Lencer WI.

Mol Biol Cell. 2003 Dec;14(12):4783-93. Epub 2003 Sep 17.

PMID:
13679513
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Conversion of apical plasma membrane sphingomyelin to ceramide attenuates the intoxication of host cells by cholera toxin.

Saslowsky DE, Lencer WI.

Cell Microbiol. 2008 Jan;10(1):67-80.

PMID:
18052945
[PubMed - indexed for MEDLINE]

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