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Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling.

Lerner-Marmarosh N, Miralem T, Gibbs PE, Maines MD.

Proc Natl Acad Sci U S A. 2008 May 13;105(19):6870-5. doi: 10.1073/pnas.0800750105. Epub 2008 May 7.


The human biliverdin reductase-based peptide fragments and biliverdin regulate protein kinase Cδ activity: the peptides are inhibitors or substrate for the protein kinase C.

Miralem T, Lerner-Marmarosh N, Gibbs PE, Tudor C, Hagen FK, Maines MD.

J Biol Chem. 2012 Jul 13;287(29):24698-712. doi: 10.1074/jbc.M111.326504. Epub 2012 May 14.


Human biliverdin reductase, a previously unknown activator of protein kinase C betaII.

Maines MD, Miralem T, Lerner-Marmarosh N, Shen J, Gibbs PE.

J Biol Chem. 2007 Mar 16;282(11):8110-22. Epub 2007 Jan 16.


Human biliverdin reductase suppresses Goodpasture antigen-binding protein (GPBP) kinase activity: the reductase regulates tumor necrosis factor-alpha-NF-kappaB-dependent GPBP expression.

Miralem T, Gibbs PE, Revert F, Saus J, Maines MD.

J Biol Chem. 2010 Apr 23;285(17):12551-8. doi: 10.1074/jbc.M109.032771. Epub 2010 Feb 22.


A bipartite mechanism for ERK2 recognition by its cognate regulators and substrates.

Zhang J, Zhou B, Zheng CF, Zhang ZY.

J Biol Chem. 2003 Aug 8;278(32):29901-12. Epub 2003 May 16.


Biliverdin reductase: more than a namesake - the reductase, its Peptide fragments, and biliverdin regulate activity of the three classes of protein kinase C.

Gibbs PE, Tudor C, Maines MD.

Front Pharmacol. 2012 Mar 13;3:31. doi: 10.3389/fphar.2012.00031. eCollection 2012.


Pleiotropic functions of biliverdin reductase: cellular signaling and generation of cytoprotective and cytotoxic bilirubin.

Kapitulnik J, Maines MD.

Trends Pharmacol Sci. 2009 Mar;30(3):129-37. doi: 10.1016/ Epub 2009 Feb 11. Review.


Down-regulation of protein kinase Cδ inhibits inducible nitric oxide synthase expression through IRF1.

Leppänen T, Korhonen R, Laavola M, Nieminen R, Tuominen RK, Moilanen E.

PLoS One. 2013;8(1):e52741. doi: 10.1371/journal.pone.0052741. Epub 2013 Jan 9.


Human biliverdin reductase-based peptides activate and inhibit glucose uptake through direct interaction with the kinase domain of insulin receptor.

Gibbs PE, Lerner-Marmarosh N, Poulin A, Farah E, Maines MD.

FASEB J. 2014 Jun;28(6):2478-91. doi: 10.1096/fj.13-247015. Epub 2014 Feb 25.


Biliverdin reductase is a transporter of haem into the nucleus and is essential for regulation of HO-1 gene expression by haematin.

Tudor C, Lerner-Marmarosh N, Engelborghs Y, Gibbs PE, Maines MD.

Biochem J. 2008 Aug 1;413(3):405-16. doi: 10.1042/BJ20080018.


Protein kinase C-δ negatively regulates T cell receptor-induced NF-κB activation by inhibiting the assembly of CARMA1 signalosome.

Liu Y, Song R, Gao Y, Li Y, Wang S, Liu HY, Wang Y, Hu YH, Shu HB.

J Biol Chem. 2012 Jun 8;287(24):20081-7. doi: 10.1074/jbc.M111.335463. Epub 2012 Apr 23.


The naturally occurring biflavonoid, ochnaflavone, inhibits LPS-induced iNOS expression, which is mediated by ERK1/2 via NF-kappaB regulation, in RAW264.7 cells.

Suh SJ, Chung TW, Son MJ, Kim SH, Moon TC, Son KH, Kim HP, Chang HW, Kim CH.

Arch Biochem Biophys. 2006 Mar 15;447(2):136-46. Epub 2006 Feb 10. Erratum in: Arch Biochem Biophys. 2010 Jan 15;493(2):249.

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