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Items: 1 to 20 of 93


Identification of a central role for complement in osteoarthritis.

Wang Q, Rozelle AL, Lepus CM, Scanzello CR, Song JJ, Larsen DM, Crish JF, Bebek G, Ritter SY, Lindstrom TM, Hwang I, Wong HH, Punzi L, Encarnacion A, Shamloo M, Goodman SB, Wyss-Coray T, Goldring SR, Banda NK, Thurman JM, Gobezie R, Crow MK, Holers VM, Lee DM, Robinson WH.

Nat Med. 2011 Nov 6;17(12):1674-9. doi: 10.1038/nm.2543.


Interleukin-6 plays an essential role in hypoxia-inducible factor 2α-induced experimental osteoarthritic cartilage destruction in mice.

Ryu JH, Yang S, Shin Y, Rhee J, Chun CH, Chun JS.

Arthritis Rheum. 2011 Sep;63(9):2732-43. doi: 10.1002/art.30451.


Brief report: carboxypeptidase B serves as a protective mediator in osteoarthritis.

Lepus CM, Song JJ, Wang Q, Wagner CA, Lindstrom TM, Chu CR, Sokolove J, Leung LL, Robinson WH.

Arthritis Rheumatol. 2014 Jan;66(1):101-6. doi: 10.1002/art.38213.


Cloning of the sixth complement component and, spatial and temporal expression profile of MAC structural and regulatory genes in chicken.

Mikrou A, Zarkadis IK.

Dev Comp Immunol. 2010 May;34(5):485-90. doi: 10.1016/j.dci.2010.01.003. Epub 2010 Jan 17.


Disturbed cartilage and joint homeostasis resulting from a loss of mitogen-inducible gene 6 in a mouse model of joint dysfunction.

Pest MA, Russell BA, Zhang YW, Jeong JW, Beier F.

Arthritis Rheumatol. 2014 Oct;66(10):2816-27. doi: 10.1002/art.38758.


Predominant role for C5b-9 in renal ischemia/reperfusion injury.

Zhou W, Farrar CA, Abe K, Pratt JR, Marsh JE, Wang Y, Stahl GL, Sacks SH.

J Clin Invest. 2000 May;105(10):1363-71.


Absence of the complement regulatory molecule CD59a leads to exacerbated neuropathology after traumatic brain injury in mice.

Stahel PF, Flierl MA, Morgan BP, Persigehl I, Stoll C, Conrad C, Touban BM, Smith WR, Beauchamp K, Schmidt OI, Ertel W, Leinhase I.

J Neuroinflammation. 2009 Jan 8;6:2. doi: 10.1186/1742-2094-6-2.


Inhibition of complement component C5 protects porcine chondrocytes from xenogeneic rejection.

Sommaggio R, Pérez-Cruz M, Brokaw JL, Máñez R, Costa C.

Osteoarthritis Cartilage. 2013 Dec;21(12):1958-67. doi: 10.1016/j.joca.2013.09.002. Epub 2013 Sep 14.


Wnt/beta-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration.

Yuasa T, Otani T, Koike T, Iwamoto M, Enomoto-Iwamoto M.

Lab Invest. 2008 Mar;88(3):264-74. doi: 10.1038/labinvest.3700747. Epub 2008 Jan 28.


Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: implications for cartilage degradation in arthritis.

Barksby HE, Milner JM, Patterson AM, Peake NJ, Hui W, Robson T, Lakey R, Middleton J, Cawston TE, Richards CD, Rowan AD.

Arthritis Rheum. 2006 Oct;54(10):3244-53.


Impact of the complement cascade on posttraumatic cartilage inflammation and degradation.

John T, Stahel PF, Morgan SJ, Schulze-Tanzil G.

Histol Histopathol. 2007 Jul;22(7):781-90. Review.


Complement regulator CD59 protects against atherosclerosis by restricting the formation of complement membrane attack complex.

Wu G, Hu W, Shahsafaei A, Song W, Dobarro M, Sukhova GK, Bronson RR, Shi GP, Rother RP, Halperin JA, Qin X.

Circ Res. 2009 Feb 27;104(4):550-8. doi: 10.1161/CIRCRESAHA.108.191361. Epub 2009 Jan 8.


Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism.

Li J, Gorski DJ, Anemaet W, Velasco J, Takeuchi J, Sandy JD, Plaas A.

Arthritis Res Ther. 2012 Jun 21;14(3):R151. doi: 10.1186/ar3887.


Modulation of leukocyte recruitment and IL-8 expression by the membrane attack complex of complement (C5b-9) in a rabbit model of antigen-induced arthritis.

Tramontini NL, Kuipers PJ, Huber CM, Murphy K, Naylor KB, Broady AJ, Kilgore KS.

Inflammation. 2002 Dec;26(6):311-9.


PGE2 inhibits MMP expression by suppressing MKK4-JNK MAP kinase-c-JUN pathway via EP4 in human articular chondrocytes.

Nishitani K, Ito H, Hiramitsu T, Tsutsumi R, Tanida S, Kitaori T, Yoshitomi H, Kobayashi M, Nakamura T.

J Cell Biochem. 2010 Feb 1;109(2):425-33. doi: 10.1002/jcb.22421.


Osteoarthritis year 2012 in review: biomarkers.

Mobasheri A.

Osteoarthritis Cartilage. 2012 Dec;20(12):1451-64. doi: 10.1016/j.joca.2012.07.009. Epub 2012 Jul 25. Review.


Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks.

Iliopoulos D, Malizos KN, Oikonomou P, Tsezou A.

PLoS One. 2008;3(11):e3740. doi: 10.1371/journal.pone.0003740. Epub 2008 Nov 17.


The membrane attack complex of complement drives the progression of atherosclerosis in apolipoprotein E knockout mice.

Lewis RD, Jackson CL, Morgan BP, Hughes TR.

Mol Immunol. 2010 Feb;47(5):1098-105. doi: 10.1016/j.molimm.2009.10.035. Epub 2009 Dec 2.

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