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Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state.

Lapasset L, Milhavet O, Prieur A, Besnard E, Babled A, Aït-Hamou N, Leschik J, Pellestor F, Ramirez JM, De Vos J, Lehmann S, Lemaitre JM.

Genes Dev. 2011 Nov 1;25(21):2248-53. doi: 10.1101/gad.173922.111.


The aging signature: a hallmark of induced pluripotent stem cells?

Rohani L, Johnson AA, Arnold A, Stolzing A.

Aging Cell. 2014 Feb;13(1):2-7. doi: 10.1111/acel.12182. Epub 2013 Nov 21. Review.


Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells.

Wang F, Yin Y, Ye X, Liu K, Zhu H, Wang L, Chiourea M, Okuka M, Ji G, Dan J, Zuo B, Li M, Zhang Q, Liu N, Chen L, Pan X, Gagos S, Keefe DL, Liu L.

Cell Res. 2012 Apr;22(4):757-68. doi: 10.1038/cr.2011.201. Epub 2011 Dec 20.


Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations.

Prigione A, Hossini AM, Lichtner B, Serin A, Fauler B, Megges M, Lurz R, Lehrach H, Makrantonaki E, Zouboulis CC, Adjaye J.

PLoS One. 2011;6(11):e27352. doi: 10.1371/journal.pone.0027352. Epub 2011 Nov 14.


Aging and reprogramming: a two-way street.

Mahmoudi S, Brunet A.

Curr Opin Cell Biol. 2012 Dec;24(6):744-56. doi: 10.1016/ Epub 2012 Nov 9. Review.


The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells.

Prigione A, Fauler B, Lurz R, Lehrach H, Adjaye J.

Stem Cells. 2010 Apr;28(4):721-33. doi: 10.1002/stem.404.


mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: a roadmap from energy metabolism to stem cell renewal and aging.

Menendez JA, Vellon L, Oliveras-Ferraros C, Cufí S, Vazquez-Martin A.

Cell Cycle. 2011 Nov 1;10(21):3658-77. doi: 10.4161/cc.10.21.18128. Epub 2011 Nov 1. Review.


Enhanced telomere rejuvenation in pluripotent cells reprogrammed via nuclear transfer relative to induced pluripotent stem cells.

Le R, Kou Z, Jiang Y, Li M, Huang B, Liu W, Li H, Kou X, He W, Rudolph KL, Ju Z, Gao S.

Cell Stem Cell. 2014 Jan 2;14(1):27-39. doi: 10.1016/j.stem.2013.11.005. Epub 2013 Nov 21.


Telomere rejuvenation during nuclear reprogramming.

Marión RM, Blasco MA.

Curr Opin Genet Dev. 2010 Apr;20(2):190-6. doi: 10.1016/j.gde.2010.01.005. Epub 2010 Feb 20. Review.


Vitamin C enhances the generation of mouse and human induced pluripotent stem cells.

Esteban MA, Wang T, Qin B, Yang J, Qin D, Cai J, Li W, Weng Z, Chen J, Ni S, Chen K, Li Y, Liu X, Xu J, Zhang S, Li F, He W, Labuda K, Song Y, Peterbauer A, Wolbank S, Redl H, Zhong M, Cai D, Zeng L, Pei D.

Cell Stem Cell. 2010 Jan 8;6(1):71-9. doi: 10.1016/j.stem.2009.12.001. Epub 2009 Dec 31.


Mitochondrial metabolism transition cooperates with nuclear reprogramming during induced pluripotent stem cell generation.

Liu W, Long Q, Chen K, Li S, Xiang G, Chen S, Liu X, Li Y, Yang L, Dong D, Jiang C, Feng Z, Qin D, Liu X.

Biochem Biophys Res Commun. 2013 Feb 22;431(4):767-71. doi: 10.1016/j.bbrc.2012.12.148. Epub 2013 Jan 16.


Telomere dynamics in human cells reprogrammed to pluripotency.

Suhr ST, Chang EA, Rodriguez RM, Wang K, Ross PJ, Beyhan Z, Murthy S, Cibelli JB.

PLoS One. 2009 Dec 2;4(12):e8124. doi: 10.1371/journal.pone.0008124. Erratum in: PLoS One. 2010;5(3) doi: 10.1371/annotation/c786d141-fd0f-45fd-80ec-96d80be620dc.


Analysis of human and mouse reprogramming of somatic cells to induced pluripotent stem cells. What is in the plate?

Boué S, Paramonov I, Barrero MJ, Izpisúa Belmonte JC.

PLoS One. 2010 Sep 17;5(9). pii: e12664. doi: 10.1371/journal.pone.0012664.


A practical and efficient cellular substrate for the generation of induced pluripotent stem cells from adults: blood-derived endothelial progenitor cells.

Geti I, Ormiston ML, Rouhani F, Toshner M, Movassagh M, Nichols J, Mansfield W, Southwood M, Bradley A, Rana AA, Vallier L, Morrell NW.

Stem Cells Transl Med. 2012 Dec;1(12):855-65. doi: 10.5966/sctm.2012-0093. Epub 2012 Nov 29.


Evolution of induced pluripotent stem cell technology.

Zhou H, Ding S.

Curr Opin Hematol. 2010 Jul;17(4):276-80. doi: 10.1097/MOH.0b013e328339f2ee. Review.


Comparative analysis of human embryonic stem cell and induced pluripotent stem cell-derived hepatocyte-like cells reveals current drawbacks and possible strategies for improved differentiation.

Jozefczuk J, Prigione A, Chavez L, Adjaye J.

Stem Cells Dev. 2011 Jul;20(7):1259-75. doi: 10.1089/scd.2010.0361. Epub 2011 Jan 24.


Efficient hematopoietic redifferentiation of induced pluripotent stem cells derived from primitive murine bone marrow cells.

Pfaff N, Lachmann N, Kohlscheen S, Sgodda M, Araúzo-Bravo MJ, Greber B, Kues W, Glage S, Baum C, Niemann H, Schambach A, Cantz T, Moritz T.

Stem Cells Dev. 2012 Mar 20;21(5):689-701. doi: 10.1089/scd.2011.0010. Epub 2011 Aug 24.


Rejuvenation of senescent cells-the road to postponing human aging and age-related disease?

Sikora E.

Exp Gerontol. 2013 Jul;48(7):661-6. doi: 10.1016/j.exger.2012.09.008. Epub 2012 Oct 11. Review.


H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs.

Chen J, Liu H, Liu J, Qi J, Wei B, Yang J, Liang H, Chen Y, Chen J, Wu Y, Guo L, Zhu J, Zhao X, Peng T, Zhang Y, Chen S, Li X, Li D, Wang T, Pei D.

Nat Genet. 2013 Jan;45(1):34-42. doi: 10.1038/ng.2491. Epub 2012 Dec 2.


Reprogramming induced pluripotent stem cells in the absence of c-Myc for differentiation into hepatocyte-like cells.

Li HY, Chien Y, Chen YJ, Chen SF, Chang YL, Chiang CH, Jeng SY, Chang CM, Wang ML, Chen LK, Hung SI, Huo TI, Lee SD, Chiou SH.

Biomaterials. 2011 Sep;32(26):5994-6005. doi: 10.1016/j.biomaterials.2011.05.009. Epub 2011 Jun 11.

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