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Degradation of p21Cip1 through anaphase-promoting complex/cyclosome and its activator Cdc20 (APC/CCdc20) ubiquitin ligase complex-mediated ubiquitylation is inhibited by cyclin-dependent kinase 2 in cardiomyocytes.

Yamada K, Tamamori-Adachi M, Goto I, Iizuka M, Yasukawa T, Aso T, Okazaki T, Kitajima S.

J Biol Chem. 2011 Dec 23;286(51):44057-66. doi: 10.1074/jbc.M111.236711. Epub 2011 Nov 1.


APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase.

Amador V, Ge S, Santamaría PG, Guardavaccaro D, Pagano M.

Mol Cell. 2007 Aug 3;27(3):462-73.


APC/C-Cdc20-mediated degradation of cyclin B participates in CSF arrest in unfertilized Xenopus eggs.

Yamamoto TM, Iwabuchi M, Ohsumi K, Kishimoto T.

Dev Biol. 2005 Mar 15;279(2):345-55.


Down-regulation of p27Kip1 promotes cell proliferation of rat neonatal cardiomyocytes induced by nuclear expression of cyclin D1 and CDK4. Evidence for impaired Skp2-dependent degradation of p27 in terminal differentiation.

Tamamori-Adachi M, Hayashida K, Nobori K, Omizu C, Yamada K, Sakamoto N, Kamura T, Fukuda K, Ogawa S, Nakayama KI, Kitajima S.

J Biol Chem. 2004 Nov 26;279(48):50429-36. Epub 2004 Sep 13.


The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction.

Nilsson J, Yekezare M, Minshull J, Pines J.

Nat Cell Biol. 2008 Dec;10(12):1411-20. doi: 10.1038/ncb1799. Epub 2008 Nov 9.


Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis.

Puliyappadamba VT, Wu W, Bevis D, Zhang L, Polin L, Kilkuskie R, Finley RL Jr, Larsen SD, Levi E, Miller FR, Wali A, Rishi AK.

J Biol Chem. 2011 Nov 4;286(44):38000-17. doi: 10.1074/jbc.M111.222398. Epub 2011 Sep 8.


Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase.

Bashir T, Dorrello NV, Amador V, Guardavaccaro D, Pagano M.

Nature. 2004 Mar 11;428(6979):190-3.


The spindle checkpoint requires cyclin-dependent kinase activity.

D'Angiolella V, Mari C, Nocera D, Rametti L, Grieco D.

Genes Dev. 2003 Oct 15;17(20):2520-5.


The APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exit.

van Zon W, Ogink J, ter Riet B, Medema RH, te Riele H, Wolthuis RM.

J Cell Biol. 2010 Aug 23;190(4):587-602. doi: 10.1083/jcb.200912084.


The anaphase-promoting complex coordinates initiation of lens differentiation.

Wu G, Glickstein S, Liu W, Fujita T, Li W, Yang Q, Duvoisin R, Wan Y.

Mol Biol Cell. 2007 Mar;18(3):1018-29. Epub 2007 Jan 10.


Cdc20: a WD40 activator for a cell cycle degradation machine.

Yu H.

Mol Cell. 2007 Jul 6;27(1):3-16. Review.


Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20.

Morrow CJ, Tighe A, Johnson VL, Scott MI, Ditchfield C, Taylor SS.

J Cell Sci. 2005 Aug 15;118(Pt 16):3639-52. Epub 2005 Jul 26.


Regulation of the action of early mitotic inhibitor 1 on the anaphase-promoting complex/cyclosome by cyclin-dependent kinases.

Moshe Y, Bar-On O, Ganoth D, Hershko A.

J Biol Chem. 2011 May 13;286(19):16647-57. doi: 10.1074/jbc.M111.223339. Epub 2011 Mar 16.


Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit.

Binné UK, Classon MK, Dick FA, Wei W, Rape M, Kaelin WG Jr, Näär AM, Dyson NJ.

Nat Cell Biol. 2007 Feb;9(2):225-32. Epub 2006 Dec 24. Erratum in: Nat Cell Biol. 2007 Mar;9(3):353.


The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C).

Sczaniecka M, Feoktistova A, May KM, Chen JS, Blyth J, Gould KL, Hardwick KG.

J Biol Chem. 2008 Aug 22;283(34):23039-47. doi: 10.1074/jbc.M803594200. Epub 2008 Jun 13.


Dephosphorylation of Cdc20 is required for its C-box-dependent activation of the APC/C.

Labit H, Fujimitsu K, Bayin NS, Takaki T, Gannon J, Yamano H.

EMBO J. 2012 Aug 1;31(15):3351-62. doi: 10.1038/emboj.2012.168. Epub 2012 Jun 19.

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