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Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicity.

Xifró X, Anglada-Huguet M, Rué L, Saavedra A, Pérez-Navarro E, Alberch J.

Mol Neurodegener. 2011 Oct 31;6:74. doi: 10.1186/1750-1326-6-74.


Activation of Elk-1 participates as a neuroprotective compensatory mechanism in models of Huntington's disease.

Anglada-Huguet M, Giralt A, Perez-Navarro E, Alberch J, Xifró X.

J Neurochem. 2012 May;121(4):639-48. doi: 10.1111/j.1471-4159.2012.07711.x. Epub 2012 Mar 28.


MicroRNA-124 targets CCNA2 and regulates cell cycle in STHdh(Q111)/Hdh(Q111) cells.

Das E, Jana NR, Bhattacharyya NP.

Biochem Biophys Res Commun. 2013 Jul 26;437(2):217-24. doi: 10.1016/j.bbrc.2013.06.041. Epub 2013 Jun 21.


Calcineurin is involved in the early activation of NMDA-mediated cell death in mutant huntingtin knock-in striatal cells.

Xifró X, García-Martínez JM, Del Toro D, Alberch J, Pérez-Navarro E.

J Neurochem. 2008 Jun;105(5):1596-612. doi: 10.1111/j.1471-4159.2008.05252.x. Epub 2008 Jan 24.


Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin.

Jin YN, Yu YV, Gundemir S, Jo C, Cui M, Tieu K, Johnson GV.

PLoS One. 2013;8(3):e57932. doi: 10.1371/journal.pone.0057932. Epub 2013 Mar 1.


Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells.

Gines S, Ivanova E, Seong IS, Saura CA, MacDonald ME.

J Biol Chem. 2003 Dec 12;278(50):50514-22. Epub 2003 Oct 1.


Differential proteomic and genomic profiling of mouse striatal cell model of Huntington's disease and control; probable implications to the disease biology.

Choudhury KR, Das S, Bhattacharyya NP.

J Proteomics. 2016 Jan 30;132:155-66. doi: 10.1016/j.jprot.2015.11.007. Epub 2015 Nov 12.


Dysregulation of system xc(-) expression induced by mutant huntingtin in a striatal neuronal cell line and in R6/2 mice.

Frederick NM, Bertho J, Patel KK, Petr GT, Bakradze E, Smith SB, Rosenberg PA.

Neurochem Int. 2014 Oct;76:59-69. doi: 10.1016/j.neuint.2014.06.017. Epub 2014 Jul 5.


Increased expression of Bim contributes to the potentiation of serum deprivation-induced apoptotic cell death in Huntington's disease knock-in striatal cell line.

Kong PJ, Kil MO, Lee H, Kim SS, Johnson GV, Chun W.

Neurol Res. 2009 Feb;31(1):77-83. doi: 10.1179/174313208X331572. Epub 2008 Aug 7.


The common inhaled anesthetic isoflurane increases aggregation of huntingtin and alters calcium homeostasis in a cell model of Huntington's disease.

Wang Q, Liang G, Yang H, Wang S, Eckenhoff MF, Wei H.

Toxicol Appl Pharmacol. 2011 Feb 1;250(3):291-8. doi: 10.1016/j.taap.2010.10.032. Epub 2010 Nov 6.


PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum.

Saavedra A, García-Martínez JM, Xifró X, Giralt A, Torres-Peraza JF, Canals JM, Díaz-Hernández M, Lucas JJ, Alberch J, Pérez-Navarro E.

Cell Death Differ. 2010 Feb;17(2):324-35. doi: 10.1038/cdd.2009.127. Epub 2009 Sep 11.


Regulation of miR-146a by RelA/NFkB and p53 in STHdh(Q111)/Hdh(Q111) cells, a cell model of Huntington's disease.

Ghose J, Sinha M, Das E, Jana NR, Bhattacharyya NP.

PLoS One. 2011;6(8):e23837. doi: 10.1371/journal.pone.0023837. Epub 2011 Aug 26.


Early down-regulation of PKCδ as a pro-survival mechanism in Huntington's disease.

Rué L, Alcalá-Vida R, López-Soop G, Creus-Muncunill J, Alberch J, Pérez-Navarro E.

Neuromolecular Med. 2014 Mar;16(1):25-37. doi: 10.1007/s12017-013-8248-8. Epub 2013 Jul 30.


Mitogen- and stress-activated protein kinase-1 deficiency is involved in expanded-huntingtin-induced transcriptional dysregulation and striatal death.

Roze E, Betuing S, Deyts C, Marcon E, Brami-Cherrier K, Pagès C, Humbert S, Mérienne K, Caboche J.

FASEB J. 2008 Apr;22(4):1083-93. Epub 2007 Nov 20.


Loss of striatal 90-kDa ribosomal S6 kinase (Rsk) is a key factor for motor, synaptic and transcription dysfunction in Huntington's disease.

Anglada-Huguet M, Giralt A, Rué L, Alberch J, Xifró X.

Biochim Biophys Acta. 2016 Jul;1862(7):1255-66. doi: 10.1016/j.bbadis.2016.04.002. Epub 2016 Apr 6.


Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis.

Reis SA, Thompson MN, Lee JM, Fossale E, Kim HH, Liao JK, Moskowitz MA, Shaw SY, Dong L, Haggarty SJ, MacDonald ME, Seong IS.

Hum Mol Genet. 2011 Jun 15;20(12):2344-55. doi: 10.1093/hmg/ddr127. Epub 2011 Mar 29.


Metabotropic glutamate receptor-mediated cell signaling pathways are altered in a mouse model of Huntington's disease.

Ribeiro FM, Paquet M, Ferreira LT, Cregan T, Swan P, Cregan SP, Ferguson SS.

J Neurosci. 2010 Jan 6;30(1):316-24. doi: 10.1523/JNEUROSCI.4974-09.2010.


Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: implication for neuroprotective therapies.

Brito V, Puigdellívol M, Giralt A, del Toro D, Alberch J, Ginés S.

Cell Death Dis. 2013 Apr 18;4:e595. doi: 10.1038/cddis.2013.116.


AMPK-α1 functions downstream of oxidative stress to mediate neuronal atrophy in Huntington's disease.

Ju TC, Chen HM, Chen YC, Chang CP, Chang C, Chern Y.

Biochim Biophys Acta. 2014 Sep;1842(9):1668-80. doi: 10.1016/j.bbadis.2014.06.012. Epub 2014 Jun 16.

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