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Items: 1 to 20 of 128

1.

Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation.

Aster JC, Bodnar N, Xu L, Karnell F, Milholland JM, Maillard I, Histen G, Nam Y, Blacklow SC, Pear WS.

PLoS One. 2011;6(10):e25645. doi: 10.1371/journal.pone.0025645. Epub 2011 Oct 13.

2.

Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1.

Aster JC, Xu L, Karnell FG, Patriub V, Pui JC, Pear WS.

Mol Cell Biol. 2000 Oct;20(20):7505-15.

3.

The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia.

Durinck K, Wallaert A, Van de Walle I, Van Loocke W, Volders PJ, Vanhauwaert S, Geerdens E, Benoit Y, Van Roy N, Poppe B, Soulier J, Cools J, Mestdagh P, Vandesompele J, Rondou P, Van Vlierberghe P, Taghon T, Speleman F.

Haematologica. 2014 Dec;99(12):1808-16. doi: 10.3324/haematol.2014.115683. Epub 2014 Oct 24.

4.

New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia.

Hales EC, Taub JW, Matherly LH.

Cell Signal. 2014 Jan;26(1):149-61. doi: 10.1016/j.cellsig.2013.09.021. Epub 2013 Oct 16. Review.

PMID:
24140475
5.

Notch dimerization is required for leukemogenesis and T-cell development.

Liu H, Chi AW, Arnett KL, Chiang MY, Xu L, Shestova O, Wang H, Li YM, Bhandoola A, Aster JC, Blacklow SC, Pear WS.

Genes Dev. 2010 Nov 1;24(21):2395-407. doi: 10.1101/gad.1975210. Epub 2010 Oct 8.

6.

TLX1 and NOTCH coregulate transcription in T cell acute lymphoblastic leukemia cells.

Riz I, Hawley TS, Luu TV, Lee NH, Hawley RG.

Mol Cancer. 2010 Jul 9;9:181. doi: 10.1186/1476-4598-9-181.

7.

Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency.

Blackburn JS, Liu S, Raiser DM, Martinez SA, Feng H, Meeker ND, Gentry J, Neuberg D, Look AT, Ramaswamy S, Bernards A, Trede NS, Langenau DM.

Leukemia. 2012 Sep;26(9):2069-78. doi: 10.1038/leu.2012.116. Epub 2012 Apr 27.

8.

Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1.

Matsushita K, Kitamura K, Rahmutulla B, Tanaka N, Ishige T, Satoh M, Hoshino T, Miyagi S, Mori T, Itoga S, Shimada H, Tomonaga T, Kito M, Nakajima-Takagi Y, Kubo S, Nakaseko C, Hatano M, Miki T, Matsuo M, Fukuyo M, Kaneda A, Iwama A, Nomura F.

Oncotarget. 2015 Mar 10;6(7):5102-17.

9.

Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1.

Li X, Gounari F, Protopopov A, Khazaie K, von Boehmer H.

J Exp Med. 2008 Nov 24;205(12):2851-61. doi: 10.1084/jem.20081561. Epub 2008 Nov 3.

10.

c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.

Weng AP, Millholland JM, Yashiro-Ohtani Y, Arcangeli ML, Lau A, Wai C, Del Bianco C, Rodriguez CG, Sai H, Tobias J, Li Y, Wolfe MS, Shachaf C, Felsher D, Blacklow SC, Pear WS, Aster JC.

Genes Dev. 2006 Aug 1;20(15):2096-109. Epub 2006 Jul 17. Erratum in: Genes Dev. 2007 Mar 1;21(5):625.

11.

Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling.

Weng AP, Nam Y, Wolfe MS, Pear WS, Griffin JD, Blacklow SC, Aster JC.

Mol Cell Biol. 2003 Jan;23(2):655-64.

12.

Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc.

Sharma VM, Calvo JA, Draheim KM, Cunningham LA, Hermance N, Beverly L, Krishnamoorthy V, Bhasin M, Capobianco AJ, Kelliher MA.

Mol Cell Biol. 2006 Nov;26(21):8022-31. Epub 2006 Sep 5.

13.

DLL4 regulates NOTCH signaling and growth of T acute lymphoblastic leukemia cells in NOD/SCID mice.

Minuzzo S, Agnusdei V, Pusceddu I, Pinazza M, Moserle L, Masiero M, Rossi E, Crescenzi M, Hoey T, Ponzoni M, Amadori A, Indraccolo S.

Carcinogenesis. 2015 Jan;36(1):115-21. doi: 10.1093/carcin/bgu223. Epub 2014 Oct 29.

14.

ZFX controls propagation and prevents differentiation of acute T-lymphoblastic and myeloid leukemia.

Weisberg SP, Smith-Raska MR, Esquilin JM, Zhang J, Arenzana TL, Lau CM, Churchill M, Pan H, Klinakis A, Dixon JE, Mirny LA, Mukherjee S, Reizis B.

Cell Rep. 2014 Feb 13;6(3):528-40. doi: 10.1016/j.celrep.2014.01.007. Epub 2014 Jan 30.

15.

Epigenetic inactivation of Notch-Hes pathway in human B-cell acute lymphoblastic leukemia.

Kuang SQ, Fang Z, Zweidler-McKay PA, Yang H, Wei Y, Gonzalez-Cervantes EA, Boumber Y, Garcia-Manero G.

PLoS One. 2013 Apr 26;8(4):e61807. doi: 10.1371/journal.pone.0061807. Print 2013.

16.

A microRNA-mediated regulatory loop modulates NOTCH and MYC oncogenic signals in B- and T-cell malignancies.

Ortega M, Bhatnagar H, Lin AP, Wang L, Aster JC, Sill H, Aguiar RC.

Leukemia. 2015 Apr;29(4):968-76. doi: 10.1038/leu.2014.302. Epub 2014 Oct 14.

17.

Investigation of deregulated genes of Notch signaling pathway in human T cell acute lymphoblastic leukemia cell lines and clinical samples.

Paryan M, Mohammadi-Yeganeh S, Samiee SM, Soleimani M, Arefian E, Azadmanesh K, Poopak B, Mostafavi E, Karimipoor M, Mahdian R.

Mol Biol Rep. 2013 Oct;40(10):5531-40. doi: 10.1007/s11033-013-2654-8. Epub 2013 Aug 29.

PMID:
23982259
18.

Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss.

Medyouf H, Gao X, Armstrong F, Gusscott S, Liu Q, Gedman AL, Matherly LH, Schultz KR, Pflumio F, You MJ, Weng AP.

Blood. 2010 Feb 11;115(6):1175-84. doi: 10.1182/blood-2009-04-214718. Epub 2009 Dec 11.

19.

Cooperation of Gata3, c-Myc and Notch in malignant transformation of double positive thymocytes.

van Hamburg JP, de Bruijn MJ, Dingjan GM, Beverloo HB, Diepstraten H, Ling KW, Hendriks RW.

Mol Immunol. 2008 Jun;45(11):3085-95. doi: 10.1016/j.molimm.2008.03.018. Epub 2008 May 8.

PMID:
18471881
20.

Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells.

Rao SS, O'Neil J, Liberator CD, Hardwick JS, Dai X, Zhang T, Tyminski E, Yuan J, Kohl NE, Richon VM, Van der Ploeg LH, Carroll PM, Draetta GF, Look AT, Strack PR, Winter CG.

Cancer Res. 2009 Apr 1;69(7):3060-8. doi: 10.1158/0008-5472.CAN-08-4295. Epub 2009 Mar 24.

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