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Results: 1 to 20 of 100

1.

Affinity maturation to improve human monoclonal antibody neutralization potency and breadth against hepatitis C virus.

Wang Y, Keck ZY, Saha A, Xia J, Conrad F, Lou J, Eckart M, Marks JD, Foung SK.

J Biol Chem. 2011 Dec 23;286(51):44218-33. doi: 10.1074/jbc.M111.290783. Epub 2011 Oct 14.

PMID:
22002064
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate.

Keck ZY, Xia J, Wang Y, Wang W, Krey T, Prentoe J, Carlsen T, Li AY, Patel AH, Lemon SM, Bukh J, Rey FA, Foung SK.

PLoS Pathog. 2012;8(4):e1002653. doi: 10.1371/journal.ppat.1002653. Epub 2012 Apr 12.

PMID:
22511875
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Mapping a region of hepatitis C virus E2 that is responsible for escape from neutralizing antibodies and a core CD81-binding region that does not tolerate neutralization escape mutations.

Keck ZY, Saha A, Xia J, Wang Y, Lau P, Krey T, Rey FA, Foung SK.

J Virol. 2011 Oct;85(20):10451-63. doi: 10.1128/JVI.05259-11. Epub 2011 Aug 3.

PMID:
21813602
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Mutations in hepatitis C virus E2 located outside the CD81 binding sites lead to escape from broadly neutralizing antibodies but compromise virus infectivity.

Keck ZY, Li SH, Xia J, von Hahn T, Balfe P, McKeating JA, Witteveldt J, Patel AH, Alter H, Rice CM, Foung SK.

J Virol. 2009 Jun;83(12):6149-60. doi: 10.1128/JVI.00248-09. Epub 2009 Mar 25.

PMID:
19321602
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Isolation of human monoclonal antibodies to the envelope e2 protein of hepatitis C virus and their characterization.

Shimizu YK, Hijikata M, Oshima M, Shimizu K, Alter HJ, Purcell RH, Yoshikura H, Hotta H.

PLoS One. 2013;8(2):e55874. doi: 10.1371/journal.pone.0055874. Epub 2013 Feb 7.

PMID:
23409074
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Nonneutralizing human antibody fragments against hepatitis C virus E2 glycoprotein modulate neutralization of binding activity of human recombinant Fabs.

Burioni R, Bugli F, Mancini N, Rosa D, Di Campli C, Moroncini G, Manzin A, Abrignani S, Varaldo PE, Clementi M, Fadda G.

Virology. 2001 Sep 15;288(1):29-35.

PMID:
11543655
[PubMed - indexed for MEDLINE]
Free Article
7.

Affinity maturation of a high-affinity human monoclonal antibody against the third hypervariable loop of human immunodeficiency virus: use of phage display to improve affinity and broaden strain reactivity.

Thompson J, Pope T, Tung JS, Chan C, Hollis G, Mark G, Johnson KS.

J Mol Biol. 1996 Feb 16;256(1):77-88.

PMID:
8609615
[PubMed - indexed for MEDLINE]
8.

Affinity maturation and characterization of a human monoclonal antibody against HIV-1 gp41.

Montgomery DL, Wang YJ, Hrin R, Luftig M, Su B, Miller MD, Wang F, Haytko P, Huang L, Vitelli S, Condra J, Liu X, Hampton R, Carfi A, Pessi A, Bianchi E, Joyce J, Lloyd C, Geleziunas R, Bramhill D, King VM, Finnefrock AC, Strohl W, An Z.

MAbs. 2009 Sep-Oct;1(5):462-74. Epub 2009 Sep 8.

PMID:
20065653
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Hepatitis C virus E2 has three immunogenic domains containing conformational epitopes with distinct properties and biological functions.

Keck ZY, Op De Beeck A, Hadlock KG, Xia J, Li TK, Dubuisson J, Foung SK.

J Virol. 2004 Sep;78(17):9224-32.

PMID:
15308717
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Human combinatorial libraries yield rare antibodies that broadly neutralize hepatitis C virus.

Johansson DX, Voisset C, Tarr AW, Aung M, Ball JK, Dubuisson J, Persson MA.

Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16269-74. Epub 2007 Oct 2.

PMID:
17911260
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Characterization of the hepatitis C virus E2 epitope defined by the broadly neutralizing monoclonal antibody AP33.

Tarr AW, Owsianka AM, Timms JM, McClure CP, Brown RJ, Hickling TP, Pietschmann T, Bartenschlager R, Patel AH, Ball JK.

Hepatology. 2006 Mar;43(3):592-601.

PMID:
16496330
[PubMed - indexed for MEDLINE]
12.

Analysis of a highly flexible conformational immunogenic domain a in hepatitis C virus E2.

Keck ZY, Li TK, Xia J, Bartosch B, Cosset FL, Dubuisson J, Foung SK.

J Virol. 2005 Nov;79(21):13199-208.

PMID:
16227243
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Improved breadth and potency of an HIV-1-neutralizing human single-chain antibody by random mutagenesis and sequential antigen panning.

Zhang MY, Shu Y, Rudolph D, Prabakaran P, Labrijn AF, Zwick MB, Lal RB, Dimitrov DS.

J Mol Biol. 2004 Jan 2;335(1):209-19.

PMID:
14659751
[PubMed - indexed for MEDLINE]
14.

Directed evolution, phage display and combination of evolved mutants: a strategy to recover the neutralization properties of the scFv version of BCF2 a neutralizing monoclonal antibody specific to scorpion toxin Cn2.

Juárez-González VR, Riaño-Umbarila L, Quintero-Hernández V, Olamendi-Portugal T, Ortiz-León M, Ortíz E, Possani LD, Becerril B.

J Mol Biol. 2005 Mar 11;346(5):1287-97. Epub 2005 Jan 16.

PMID:
15713481
[PubMed - indexed for MEDLINE]
15.

New neutralizing antibody epitopes in hepatitis C virus envelope glycoproteins are revealed by dissecting peptide recognition profiles.

Kachko A, Kochneva G, Sivolobova G, Grazhdantseva A, Lupan T, Zubkova I, Wells F, Merchlinsky M, Williams O, Watanabe H, Ivanova A, Shvalov A, Loktev V, Netesov S, Major ME.

Vaccine. 2011 Dec 9;30(1):69-77. doi: 10.1016/j.vaccine.2011.10.045. Epub 2011 Oct 29.

PMID:
22041300
[PubMed - indexed for MEDLINE]
16.

Hepatitis C virus (HCV) infection may elicit neutralizing antibodies targeting epitopes conserved in all viral genotypes.

Mancini N, Diotti RA, Perotti M, Sautto G, Clementi N, Nitti G, Patel AH, Ball JK, Clementi M, Burioni R.

PLoS One. 2009 Dec 11;4(12):e8254. doi: 10.1371/journal.pone.0008254.

PMID:
20011511
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Human recombinant single-chain antibody fragments, specific for the hypervariable region 1 of hepatitis C virus, from immune phage-display libraries.

Zhai W, Davies J, Shang DZ, Chan SW, Allain JP.

J Viral Hepat. 1999 Mar;6(2):115-24.

PMID:
10607222
[PubMed - indexed for MEDLINE]
18.

Generation of a panel of related human scFv antibodies with high affinities for human CEA.

Osbourn JK, Field A, Wilton J, Derbyshire E, Earnshaw JC, Jones PT, Allen D, McCafferty J.

Immunotechnology. 1996 Sep;2(3):181-96.

PMID:
9373311
[PubMed - indexed for MEDLINE]
19.

Increased antibody affinity confers broad in vitro protection against escape mutants of severe acute respiratory syndrome coronavirus.

Rani M, Bolles M, Donaldson EF, Van Blarcom T, Baric R, Iverson B, Georgiou G.

J Virol. 2012 Sep;86(17):9113-21. doi: 10.1128/JVI.00233-12. Epub 2012 Jun 13.

PMID:
22696652
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Neutralization activity and kinetics of two broad-range human monoclonal IgG1 derived from recombinant Fab fragments and directed against Hepatitis C virus E2 glycoprotein.

Diotti RA, Sautto GA, Solforosi L, Mancini N, Clementi M, Burioni R.

New Microbiol. 2012 Oct;35(4):475-9. Epub 2012 Oct 1.

PMID:
23109015
[PubMed - indexed for MEDLINE]
Free Article

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