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Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential.

Chen YB, Aon MA, Hsu YT, Soane L, Teng X, McCaffery JM, Cheng WC, Qi B, Li H, Alavian KN, Dayhoff-Brannigan M, Zou S, Pineda FJ, O'Rourke B, Ko YH, Pedersen PL, Kaczmarek LK, Jonas EA, Hardwick JM.

J Cell Biol. 2011 Oct 17;195(2):263-76. doi: 10.1083/jcb.201108059. Epub 2011 Oct 10.


Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase.

Alavian KN, Li H, Collis L, Bonanni L, Zeng L, Sacchetti S, Lazrove E, Nabili P, Flaherty B, Graham M, Chen Y, Messerli SM, Mariggio MA, Rahner C, McNay E, Shore GC, Smith PJ, Hardwick JM, Jonas EA.

Nat Cell Biol. 2011 Sep 18;13(10):1224-33. doi: 10.1038/ncb2330. Erratum in: Nat Cell Biol. 2011 Nov;13(11):1383.


Metaxin deficiency alters mitochondrial membrane permeability and leads to resistance to TNF-induced cell killing.

Ono K, Wang X, Kim SO, Armstrong LC, Bornstein P, Han J.

Protein Cell. 2010 Feb;1(2):161-73. doi: 10.1007/s13238-010-0017-y. Erratum in: Protein Cell. 2010 Dec;1(12):1128.


Bcl-x(L) blocks a mitochondrial inner membrane channel and prevents Ca2+ overload-mediated cell death.

Tornero D, Posadas I, Ceña V.

PLoS One. 2011;6(6):e20423. doi: 10.1371/journal.pone.0020423. Epub 2011 Jun 2.


Biochemical and genetic analysis of the mitochondrial response of yeast to BAX and BCL-X(L).

Gross A, Pilcher K, Blachly-Dyson E, Basso E, Jockel J, Bassik MC, Korsmeyer SJ, Forte M.

Mol Cell Biol. 2000 May;20(9):3125-36.


An interaction between Bcl-xL and the voltage-dependent anion channel (VDAC) promotes mitochondrial Ca2+ uptake.

Huang H, Hu X, Eno CO, Zhao G, Li C, White C.

J Biol Chem. 2013 Jul 5;288(27):19870-81. doi: 10.1074/jbc.M112.448290. Epub 2013 May 17.


Facilitation of mitochondrial outer and inner membrane permeabilization and cell death in oxidative stress by a novel Bcl-2 homology 3 domain protein.

Szigeti A, Hocsak E, Rapolti E, Racz B, Boronkai A, Pozsgai E, Debreceni B, Bognar Z, Bellyei S, Sumegi B, Gallyas F Jr.

J Biol Chem. 2010 Jan 15;285(3):2140-51. doi: 10.1074/jbc.M109.015222. Epub 2009 Nov 9.


Bcl-XL inhibits membrane permeabilization by competing with Bax.

Billen LP, Kokoski CL, Lovell JF, Leber B, Andrews DW.

PLoS Biol. 2008 Jun 10;6(6):e147. doi: 10.1371/journal.pbio.0060147.


The multidomain proapoptotic molecules Bax and Bak are directly activated by heat.

Pagliari LJ, Kuwana T, Bonzon C, Newmeyer DD, Tu S, Beere HM, Green DR.

Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17975-80. Epub 2005 Dec 5.


Fusarial toxin-induced toxicity in cultured cells and in isolated mitochondria involves PTPC-dependent activation of the mitochondrial pathway of apoptosis.

Bouaziz C, Martel C, Sharaf el dein O, Abid-Essefi S, Brenner C, Lemaire C, Bacha H.

Toxicol Sci. 2009 Aug;110(2):363-75. doi: 10.1093/toxsci/kfp117. Epub 2009 Jun 18.


Ceramide channels: destabilization by Bcl-xL and role in apoptosis.

Chang KT, Anishkin A, Patwardhan GA, Beverly LJ, Siskind LJ, Colombini M.

Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):2374-84. doi: 10.1016/j.bbamem.2015.07.013. Epub 2015 Jul 26.


Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice.

He L, Perkins GA, Poblenz AT, Harris JB, Hung M, Ellisman MH, Fox DA.

Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1022-7. Epub 2003 Jan 22. Erratum in: Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4530.


Bcl-xL promotes the open configuration of the voltage-dependent anion channel and metabolite passage through the outer mitochondrial membrane.

Vander Heiden MG, Li XX, Gottleib E, Hill RB, Thompson CB, Colombini M.

J Biol Chem. 2001 Jun 1;276(22):19414-9. Epub 2001 Mar 20.


BAX insertion, oligomerization, and outer membrane permeabilization in brain mitochondria: role of permeability transition and SH-redox regulation.

Brustovetsky T, Li T, Yang Y, Zhang JT, Antonsson B, Brustovetsky N.

Biochim Biophys Acta. 2010 Nov;1797(11):1795-806. doi: 10.1016/j.bbabio.2010.07.006. Epub 2010 Jul 23.


B cell lymphoma-2 (BCL-2) homology domain 3 (BH3) mimetics demonstrate differential activities dependent upon the functional repertoire of pro- and anti-apoptotic BCL-2 family proteins.

Renault TT, Elkholi R, Bharti A, Chipuk JE.

J Biol Chem. 2014 Sep 19;289(38):26481-91. doi: 10.1074/jbc.M114.569632. Epub 2014 Aug 5.


F1FO ATPase vesicle preparation and technique for performing patch clamp recordings of submitochondrial vesicle membranes.

Sacchetti S, Alavian KN, Lazrove E, Jonas EA.

J Vis Exp. 2013 May 4;(75):e4394. doi: 10.3791/4394.


Mitochondrial shape governs BAX-induced membrane permeabilization and apoptosis.

Renault TT, Floros KV, Elkholi R, Corrigan KA, Kushnareva Y, Wieder SY, Lindtner C, Serasinghe MN, Asciolla JJ, Buettner C, Newmeyer DD, Chipuk JE.

Mol Cell. 2015 Jan 8;57(1):69-82. doi: 10.1016/j.molcel.2014.10.028. Epub 2014 Dec 4.


Regulation of Bax mitochondrial localization by Bcl-2 and Bcl-x(L): keep your friends close but your enemies closer.

Renault TT, Teijido O, Antonsson B, Dejean LM, Manon S.

Int J Biochem Cell Biol. 2013 Jan;45(1):64-7. doi: 10.1016/j.biocel.2012.09.022. Epub 2012 Oct 11. Review.


The C-terminal helix of Bcl-x(L) mediates Bax retrotranslocation from the mitochondria.

Todt F, Cakir Z, Reichenbach F, Youle RJ, Edlich F.

Cell Death Differ. 2013 Feb;20(2):333-42. doi: 10.1038/cdd.2012.131. Epub 2012 Oct 19.

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