Format
Sort by

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 107

1.

OTX2 directly activates cell cycle genes and inhibits differentiation in medulloblastoma cells.

Bunt J, Hasselt NE, Zwijnenburg DA, Hamdi M, Koster J, Versteeg R, Kool M.

Int J Cancer. 2012 Jul 15;131(2):E21-32. doi: 10.1002/ijc.26474. Epub 2011 Nov 8.

2.

Regulation of cell cycle genes and induction of senescence by overexpression of OTX2 in medulloblastoma cell lines.

Bunt J, de Haas TG, Hasselt NE, Zwijnenburg DA, Koster J, Versteeg R, Kool M.

Mol Cancer Res. 2010 Oct;8(10):1344-57. doi: 10.1158/1541-7786.MCR-09-0546. Epub 2010 Sep 13.

3.

OTX2 sustains a bivalent-like state of OTX2-bound promoters in medulloblastoma by maintaining their H3K27me3 levels.

Bunt J, Hasselt NA, Zwijnenburg DA, Koster J, Versteeg R, Kool M.

Acta Neuropathol. 2013 Mar;125(3):385-94. doi: 10.1007/s00401-012-1069-2. Epub 2012 Nov 18.

PMID:
23179372
4.

OTX1 and OTX2 expression correlates with the clinicopathologic classification of medulloblastomas.

de Haas T, Oussoren E, Grajkowska W, Perek-Polnik M, Popovic M, Zadravec-Zaletel L, Perera M, Corte G, Wirths O, van Sluis P, Pietsch T, Troost D, Baas F, Versteeg R, Kool M.

J Neuropathol Exp Neurol. 2006 Feb;65(2):176-86.

5.

Joint binding of OTX2 and MYC in promotor regions is associated with high gene expression in medulloblastoma.

Bunt J, Hasselt NE, Zwijnenburg DA, Koster J, Versteeg R, Kool M.

PLoS One. 2011;6(10):e26058. doi: 10.1371/journal.pone.0026058. Epub 2011 Oct 10.

6.

OTX2 exhibits cell-context-dependent effects on cellular and molecular properties of human embryonic neural precursors and medulloblastoma cells.

Kaur R, Aiken C, Morrison LC, Rao R, Del Bigio MR, Rampalli S, Werbowetski-Ogilvie T.

Dis Model Mech. 2015 Oct 1;8(10):1295-309. doi: 10.1242/dmm.020594. Epub 2015 Aug 6.

7.

OTX2 represses myogenic and neuronal differentiation in medulloblastoma cells.

Bai RY, Staedtke V, Lidov HG, Eberhart CG, Riggins GJ.

Cancer Res. 2012 Nov 15;72(22):5988-6001. doi: 10.1158/0008-5472.CAN-12-0614. Epub 2012 Sep 17.

8.

Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells.

Wortham M, Jin G, Sun JL, Bigner DD, He Y, Yan H.

PLoS One. 2012;7(4):e36211. doi: 10.1371/journal.pone.0036211. Epub 2012 Apr 27.

9.

MiR-206, a Cerebellum Enriched miRNA Is Downregulated in All Medulloblastoma Subgroups and Its Overexpression Is Necessary for Growth Inhibition of Medulloblastoma Cells.

Panwalkar P, Moiyadi A, Goel A, Shetty P, Goel N, Sridhar E, Shirsat N.

J Mol Neurosci. 2015 Jul;56(3):673-80. doi: 10.1007/s12031-015-0548-z. Epub 2015 Apr 10.

PMID:
25859932
10.

miR-219 inhibits the proliferation, migration and invasion of medulloblastoma cells by targeting CD164.

Shi JA, Lu DL, Huang X, Tan W.

Int J Mol Med. 2014 Jul;34(1):237-43. doi: 10.3892/ijmm.2014.1749. Epub 2014 Apr 22.

PMID:
24756834
11.

Chromatin accessibility mapping identifies mediators of basal transcription and retinoid-induced repression of OTX2 in medulloblastoma.

Wortham M, Guo C, Zhang M, Song L, Lee BK, Iyer VR, Furey TS, Crawford GE, Yan H, He Y.

PLoS One. 2014 Sep 8;9(9):e107156. doi: 10.1371/journal.pone.0107156. eCollection 2014.

12.

OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas.

Adamson DC, Shi Q, Wortham M, Northcott PA, Di C, Duncan CG, Li J, McLendon RE, Bigner DD, Taylor MD, Yan H.

Cancer Res. 2010 Jan 1;70(1):181-91. doi: 10.1158/0008-5472.CAN-09-2331. Epub 2009 Dec 22.

13.

Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid.

Di C, Liao S, Adamson DC, Parrett TJ, Broderick DK, Shi Q, Lengauer C, Cummins JM, Velculescu VE, Fults DW, McLendon RE, Bigner DD, Yan H.

Cancer Res. 2005 Feb 1;65(3):919-24.

14.

Evaluation of retinoic acid therapy for OTX2-positive medulloblastomas.

Bai R, Siu IM, Tyler BM, Staedtke V, Gallia GL, Riggins GJ.

Neuro Oncol. 2010 Jul;12(7):655-63. doi: 10.1093/neuonc/nop062. Epub 2010 Feb 5.

15.

Genomic amplification of orthodenticle homologue 2 in medulloblastomas.

Boon K, Eberhart CG, Riggins GJ.

Cancer Res. 2005 Feb 1;65(3):703-7.

16.

Expression patterns and potential roles of SIRT1 in human medulloblastoma cells in vivo and in vitro.

Ma JX, Li H, Chen XM, Yang XH, Wang Q, Wu ML, Kong QY, Li ZX, Liu J.

Neuropathology. 2013 Feb;33(1):7-16. doi: 10.1111/j.1440-1789.2012.01318.x. Epub 2012 Apr 27.

PMID:
22537175
17.

Identification of a neuronal transcription factor network involved in medulloblastoma development.

Lastowska M, Al-Afghani H, Al-Balool HH, Sheth H, Mercer E, Coxhead JM, Redfern CP, Peters H, Burt AD, Santibanez-Koref M, Bacon CM, Chesler L, Rust AG, Adams DJ, Williamson D, Clifford SC, Jackson MS.

Acta Neuropathol Commun. 2013 Jul 11;1:35. doi: 10.1186/2051-5960-1-35.

18.

Aberrantly Expressed OTX Homeobox Genes Deregulate B-Cell Differentiation in Hodgkin Lymphoma.

Nagel S, Ehrentraut S, Meyer C, Kaufmann M, Drexler HG, MacLeod RA.

PLoS One. 2015 Sep 25;10(9):e0138416. doi: 10.1371/journal.pone.0138416. eCollection 2015.

19.

OTX2 is a therapeutic target for retinoblastoma and may function as a common factor between C-MYC, CRX, and phosphorylated RB pathways.

Li J, Di C, Jing J, Di Q, Nakhla J, Adamson DC.

Int J Oncol. 2015 Nov;47(5):1703-10. doi: 10.3892/ijo.2015.3179. Epub 2015 Sep 23.

PMID:
26397460
20.

Role of MXD3 in proliferation of DAOY human medulloblastoma cells.

Barisone GA, Ngo T, Tran M, Cortes D, Shahi MH, Nguyen TV, Perez-Lanza D, Matayasuwan W, Díaz E.

PLoS One. 2012;7(7):e38508. doi: 10.1371/journal.pone.0038508. Epub 2012 Jul 10.

Items per page

Supplemental Content

Write to the Help Desk