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Items: 1 to 20 of 254

1.

Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics.

Doliba NM, Qin W, Najafi H, Liu C, Buettger CW, Sotiris J, Collins HW, Li C, Stanley CA, Wilson DF, Grimsby J, Sarabu R, Naji A, Matschinsky FM.

Am J Physiol Endocrinol Metab. 2012 Jan 1;302(1):E87-E102. doi: 10.1152/ajpendo.00218.2011. Epub 2011 Sep 27.

2.

Glucagon-like peptide-1 and islet lipolysis.

Sörhede Winzell M, Ahrén B.

Horm Metab Res. 2004 Nov-Dec;36(11-12):795-803.

PMID:
15655711
3.

Glucose-dependent modulation of insulin secretion and intracellular calcium ions by GKA50, a glucokinase activator.

Johnson D, Shepherd RM, Gill D, Gorman T, Smith DM, Dunne MJ.

Diabetes. 2007 Jun;56(6):1694-702. Epub 2007 Mar 14.

4.

Exendin-4 ameliorates diabetic symptoms through activation of glucokinase.

Dhanesha N, Joharapurkar A, Shah G, Dhote V, Kshirsagar S, Bahekar R, Jain M.

J Diabetes. 2012 Dec;4(4):369-77. doi: 10.1111/j.1753-0407.2012.00193.x.

PMID:
22356440
5.

Glucagon-like peptide-1 induced signaling and insulin secretion do not drive fuel and energy metabolism in primary rodent pancreatic beta-cells.

Peyot ML, Gray JP, Lamontagne J, Smith PJ, Holz GG, Madiraju SR, Prentki M, Heart E.

PLoS One. 2009 Jul 13;4(7):e6221. doi: 10.1371/journal.pone.0006221.

6.

Defective stimulus-secretion coupling in islets of Psammomys obesus, an animal model for type 2 diabetes.

Nesher R, Warwar N, Khan A, Efendic S, Cerasi E, Kaiser N.

Diabetes. 2001 Feb;50(2):308-14.

7.

Treatment with exendin-4 improves the antidiabetic efficacy and reverses hepatic steatosis in glucokinase activator treated db/db mice.

Dhanesha N, Joharapurkar A, Shah G, Kshirsagar S, Patel V, Patel K, Bahekar R, Jain M.

Eur J Pharmacol. 2013 Aug 15;714(1-3):188-92. doi: 10.1016/j.ejphar.2013.06.015. Epub 2013 Jun 25.

PMID:
23810686
8.

Medicine. Drug deals diabetes a one-two punch.

Couzin J.

Science. 2003 Jul 18;301(5631):290. No abstract available.

PMID:
12869732
9.

Allosteric activators of glucokinase: potential role in diabetes therapy.

Grimsby J, Sarabu R, Corbett WL, Haynes NE, Bizzarro FT, Coffey JW, Guertin KR, Hilliard DW, Kester RF, Mahaney PE, Marcus L, Qi L, Spence CL, Tengi J, Magnuson MA, Chu CA, Dvorozniak MT, Matschinsky FM, Grippo JF.

Science. 2003 Jul 18;301(5631):370-3.

10.

Tacrolimus suppresses glucose-induced insulin release from pancreatic islets by reducing glucokinase activity.

Radu RG, Fujimoto S, Mukai E, Takehiro M, Shimono D, Nabe K, Shimodahira M, Kominato R, Aramaki Y, Nishi Y, Funakoshi S, Yamada Y, Seino Y.

Am J Physiol Endocrinol Metab. 2005 Feb;288(2):E365-71. Epub 2004 Oct 12.

11.

Concordant glucose induction of glucokinase, glucose usage, and glucose-stimulated insulin release in pancreatic islets maintained in organ culture.

Liang Y, Najafi H, Smith RM, Zimmerman EC, Magnuson MA, Tal M, Matschinsky FM.

Diabetes. 1992 Jul;41(7):792-806.

PMID:
1612193
12.

Insulinotropic actions of exendin-4 and glucagon-like peptide-1 in vivo and in vitro.

Parkes DG, Pittner R, Jodka C, Smith P, Young A.

Metabolism. 2001 May;50(5):583-9.

PMID:
11319721
13.

Peptidergic regulation of maturation of the stimulus-secretion coupling in fetal islet beta cells.

Sjöholm A, Sandberg E, Ostenson CG, Efendić S.

Pancreas. 2000 Apr;20(3):282-9.

PMID:
10766455
14.

The glucagon-like peptide-1 receptor agonist exenatide restores impaired pro-islet amyloid polypeptide processing in cultured human islets: implications in type 2 diabetes and islet transplantation.

Park YJ, Ao Z, Kieffer TJ, Chen H, Safikhan N, Thompson DM, Meloche M, Warnock GL, Marzban L.

Diabetologia. 2013 Mar;56(3):508-19. doi: 10.1007/s00125-012-2802-z. Epub 2012 Dec 23.

PMID:
23262664
15.
16.

Changes induced by sucrose administration on glucose metabolism in pancreatic islets in normal hamsters.

Massa ML, Borelli MI, Del Zotto H, Gagliardino JJ.

J Endocrinol. 2001 Dec;171(3):551-6.

17.

Exendin-4 suppresses SRC activation and reactive oxygen species production in diabetic Goto-Kakizaki rat islets in an Epac-dependent manner.

Mukai E, Fujimoto S, Sato H, Oneyama C, Kominato R, Sato Y, Sasaki M, Nishi Y, Okada M, Inagaki N.

Diabetes. 2011 Jan;60(1):218-26. doi: 10.2337/db10-0021. Epub 2010 Oct 26.

18.

Effects of exendin-4 on islets from type 2 diabetes patients.

Lupi R, Mancarella R, Del Guerra S, Bugliani M, Del Prato S, Boggi U, Mosca F, Filipponi F, Marchetti P.

Diabetes Obes Metab. 2008 Jun;10(6):515-9. doi: 10.1111/j.1463-1326.2007.00838.x. Epub 2008 Jan 14.

PMID:
18201204
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