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Results: 1 to 20 of 99

1.

Deletion of Syk in neutrophils prevents immune complex arthritis.

Elliott ER, Van Ziffle JA, Scapini P, Sullivan BM, Locksley RM, Lowell CA.

J Immunol. 2011 Oct 15;187(8):4319-30. doi: 10.4049/jimmunol.1100341. Epub 2011 Sep 14.

PMID:
21918195
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Syk-dependent signaling pathways in neutrophils and macrophages are indispensable in the pathogenesis of anti-collagen antibody-induced arthritis.

Ozaki N, Suzuki S, Ishida M, Harada Y, Tanaka K, Sato Y, Kono T, Kubo M, Kitamura D, Encinas J, Hara H, Yoshida H.

Int Immunol. 2012 Sep;24(9):539-50. doi: 10.1093/intimm/dxs078.

PMID:
22914861
[PubMed - indexed for MEDLINE]
Free Article
3.

Induced Syk deletion leads to suppressed allergic responses but has no effect on neutrophil or monocyte migration in vivo.

Wex E, Bouyssou T, Duechs MJ, Erb KJ, Gantner F, Sanderson MP, Schnapp A, Stierstorfer BE, Wollin L.

Eur J Immunol. 2011 Nov;41(11):3208-18. doi: 10.1002/eji.201141502. Epub 2011 Sep 26.

PMID:
21830208
[PubMed - indexed for MEDLINE]
4.

R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation.

Braselmann S, Taylor V, Zhao H, Wang S, Sylvain C, Baluom M, Qu K, Herlaar E, Lau A, Young C, Wong BR, Lovell S, Sun T, Park G, Argade A, Jurcevic S, Pine P, Singh R, Grossbard EB, Payan DG, Masuda ES.

J Pharmacol Exp Ther. 2006 Dec;319(3):998-1008. Epub 2006 Aug 31. Erratum in: J Pharmacol Exp Ther. 2013 May;345(2):326.

PMID:
16946104
[PubMed - indexed for MEDLINE]
Free Article
5.

Genetic deficiency of Syk protects mice from autoantibody-induced arthritis.

Jakus Z, Simon E, Balázs B, Mócsai A.

Arthritis Rheum. 2010 Jul;62(7):1899-910. doi: 10.1002/art.27438.

PMID:
20201079
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

C5a receptor enables participation of mast cells in immune complex arthritis independently of Fcγ receptor modulation.

Nigrovic PA, Malbec O, Lu B, Markiewski MM, Kepley C, Gerard N, Gerard C, Daëron M, Lee DM.

Arthritis Rheum. 2010 Nov;62(11):3322-33. doi: 10.1002/art.27659.

PMID:
20662064
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

The Vav binding site of the non-receptor tyrosine kinase Syk at Tyr 348 is critical for beta2 integrin (CD11/CD18)-mediated neutrophil migration.

Schymeinsky J, Sindrilaru A, Frommhold D, Sperandio M, Gerstl R, Then C, Mócsai A, Scharffetter-Kochanek K, Walzog B.

Blood. 2006 Dec 1;108(12):3919-27. Epub 2006 Aug 1.

PMID:
16882714
[PubMed - indexed for MEDLINE]
Free Article
8.

Selective inhibition of spleen tyrosine kinase (SYK) with a novel orally bioavailable small molecule inhibitor, RO9021, impinges on various innate and adaptive immune responses: implications for SYK inhibitors in autoimmune disease therapy.

Liao C, Hsu J, Kim Y, Hu DQ, Xu D, Zhang J, Pashine A, Menke J, Whittard T, Romero N, Truitt T, Slade M, Lukacs C, Hermann J, Zhou M, Lucas M, Narula S, DeMartino J, Tan SL.

Arthritis Res Ther. 2013 Oct 4;15(5):R146. doi: 10.1186/ar4329.

PMID:
24286216
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Regulation of human neutrophil Fcγ receptor IIa by C5a receptor promotes inflammatory arthritis in mice.

Tsuboi N, Ernandez T, Li X, Nishi H, Cullere X, Mekala D, Hazen M, Köhl J, Lee DM, Mayadas TN.

Arthritis Rheum. 2011 Feb;63(2):467-78. doi: 10.1002/art.30141.

PMID:
21280001
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Specific inhibition of spleen tyrosine kinase suppresses leukocyte immune function and inflammation in animal models of rheumatoid arthritis.

Coffey G, DeGuzman F, Inagaki M, Pak Y, Delaney SM, Ives D, Betz A, Jia ZJ, Pandey A, Baker D, Hollenbach SJ, Phillips DR, Sinha U.

J Pharmacol Exp Ther. 2012 Feb;340(2):350-9. doi: 10.1124/jpet.111.188441. Epub 2011 Oct 31.

PMID:
22040680
[PubMed - indexed for MEDLINE]
Free Article
11.

Mast cell deficiency in Kit(W-sh) mice does not impair antibody-mediated arthritis.

Zhou JS, Xing W, Friend DS, Austen KF, Katz HR.

J Exp Med. 2007 Nov 26;204(12):2797-802. Epub 2007 Nov 6.

PMID:
17998392
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Syk and Lyn mediate distinct Syk phosphorylation events in FcɛRI-signal transduction: implications for regulation of IgE-mediated degranulation.

Sanderson MP, Wex E, Kono T, Uto K, Schnapp A.

Mol Immunol. 2010 Nov-Dec;48(1-3):171-8. doi: 10.1016/j.molimm.2010.08.012. Epub 2010 Sep 15.

PMID:
20828828
[PubMed - indexed for MEDLINE]
13.

Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection.

Van Ziffle JA, Lowell CA.

Blood. 2009 Nov 26;114(23):4871-82. doi: 10.1182/blood-2009-05-220806. Epub 2009 Oct 1.

PMID:
19797524
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

The Syk protein tyrosine kinase is essential for Fcgamma receptor signaling in macrophages and neutrophils.

Kiefer F, Brumell J, Al-Alawi N, Latour S, Cheng A, Veillette A, Grinstein S, Pawson T.

Mol Cell Biol. 1998 Jul;18(7):4209-20.

PMID:
9632805
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation.

Guma M, Ronacher L, Liu-Bryan R, Takai S, Karin M, Corr M.

Arthritis Rheum. 2009 Dec;60(12):3642-50. doi: 10.1002/art.24959.

PMID:
19950258
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

The scaffold protein prohibitin is required for antigen-stimulated signaling in mast cells.

Kim do K, Kim HS, Kim AR, Jang GH, Kim HW, Park YH, Kim B, Park YM, Beaven MA, Kim YM, Choi WS.

Sci Signal. 2013 Sep 10;6(292):ra80. doi: 10.1126/scisignal.2004098.

PMID:
24023254
[PubMed - indexed for MEDLINE]
17.

Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis.

Jakus Z, Simon E, Frommhold D, Sperandio M, Mócsai A.

J Exp Med. 2009 Mar 16;206(3):577-93. doi: 10.1084/jem.20081859. Epub 2009 Mar 9.

PMID:
19273622
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

CEACAM1 negatively regulates IL-1β production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex.

Lu R, Pan H, Shively JE.

PLoS Pathog. 2012;8(4):e1002597. doi: 10.1371/journal.ppat.1002597. Epub 2012 Apr 5.

PMID:
22496641
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

A novel druglike spleen tyrosine kinase binder prevents anaphylactic shock when administered orally.

Mazuc E, Villoutreix BO, Malbec O, Roumier T, Fleury S, Leonetti JP, Dombrowicz D, Daëron M, Martineau P, Dariavach P.

J Allergy Clin Immunol. 2008 Jul;122(1):188-94, 194.e1-3. doi: 10.1016/j.jaci.2008.04.026. Epub 2008 Jun 9.

PMID:
18539317
[PubMed - indexed for MEDLINE]
20.

Swiprosin-1/EFhd2 controls B cell receptor signaling through the assembly of the B cell receptor, Syk, and phospholipase C gamma2 in membrane rafts.

Kroczek C, Lang C, Brachs S, Grohmann M, Dütting S, Schweizer A, Nitschke L, Feller SM, Jäck HM, Mielenz D.

J Immunol. 2010 Apr 1;184(7):3665-76. doi: 10.4049/jimmunol.0903642. Epub 2010 Mar 1.

PMID:
20194721
[PubMed - indexed for MEDLINE]
Free Article

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