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Results: 1 to 20 of 102

1.

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets.

Josefsson EC, James C, Henley KJ, Debrincat MA, Rogers KL, Dowling MR, White MJ, Kruse EA, Lane RM, Ellis S, Nurden P, Mason KD, O'Reilly LA, Roberts AW, Metcalf D, Huang DC, Kile BT.

J Exp Med. 2011 Sep 26;208(10):2017-31. doi: 10.1084/jem.20110750. Epub 2011 Sep 12.

PMID:
21911424
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function.

White MJ, Schoenwaelder SM, Josefsson EC, Jarman KE, Henley KJ, James C, Debrincat MA, Jackson SP, Huang DC, Kile BT.

Blood. 2012 May 3;119(18):4283-90. doi: 10.1182/blood-2011-11-394858. Epub 2012 Jan 31.

PMID:
22294729
[PubMed - indexed for MEDLINE]
Free Article
3.

BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets.

Kodama T, Takehara T, Hikita H, Shimizu S, Shigekawa M, Li W, Miyagi T, Hosui A, Tatsumi T, Ishida H, Kanto T, Hiramatsu N, Yin XM, Hayashi N.

J Biol Chem. 2011 Apr 22;286(16):13905-13. doi: 10.1074/jbc.M110.195370. Epub 2011 Mar 2.

PMID:
21367852
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages.

Kodama T, Hikita H, Kawaguchi T, Shigekawa M, Shimizu S, Hayashi Y, Li W, Miyagi T, Hosui A, Tatsumi T, Kanto T, Hiramatsu N, Kiyomizu K, Tadokoro S, Tomiyama Y, Hayashi N, Takehara T.

Cell Death Differ. 2012 Nov;19(11):1856-69. doi: 10.1038/cdd.2012.88. Epub 2012 Jul 13.

PMID:
22790873
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Regulation of stress-induced nuclear protein redistribution: a new function of Bax and Bak uncoupled from Bcl-x(L).

Lindenboim L, Blacher E, Borner C, Stein R.

Cell Death Differ. 2010 Feb;17(2):346-59. doi: 10.1038/cdd.2009.145. Epub 2009 Oct 9.

PMID:
19816507
[PubMed - indexed for MEDLINE]
Free Article
6.

Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival.

Debrincat MA, Josefsson EC, James C, Henley KJ, Ellis S, Lebois M, Betterman KL, Lane RM, Rogers KL, White MJ, Roberts AW, Harvey NL, Metcalf D, Kile BT.

Blood. 2012 Jun 14;119(24):5850-8. doi: 10.1182/blood-2011-12-398834. Epub 2012 Feb 28.

PMID:
22374700
[PubMed - indexed for MEDLINE]
Free Article
7.

Caspase-mediated Bak activation and cytochrome c release during intrinsic apoptotic cell death in Jurkat cells.

Shawgo ME, Shelton SN, Robertson JD.

J Biol Chem. 2008 Dec 19;283(51):35532-8. doi: 10.1074/jbc.M807656200. Epub 2008 Oct 15.

PMID:
18927073
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

P2Y12 protects platelets from apoptosis via PI3k-dependent Bak/Bax inactivation.

Zhang S, Ye J, Zhang Y, Xu X, Liu J, Zhang SH, Kunapuli SP, Ding Z.

J Thromb Haemost. 2013 Jan;11(1):149-60. doi: 10.1111/jth.12063.

PMID:
23140172
[PubMed - indexed for MEDLINE]
9.

Retinal ischemia-induced apoptosis is associated with alteration in Bax and Bcl-x(L) expression rather than modifications in Bak and Bcl-2.

Produit-Zengaffinen N, Pournaras CJ, Schorderet DF.

Mol Vis. 2009 Oct 19;15:2101-10.

PMID:
19862336
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways.

Josefsson EC, Burnett DL, Lebois M, Debrincat MA, White MJ, Henley KJ, Lane RM, Moujalled D, Preston SP, O'Reilly LA, Pellegrini M, Metcalf D, Strasser A, Kile BT.

Nat Commun. 2014 Mar 17;5:3455. doi: 10.1038/ncomms4455.

PMID:
24632563
[PubMed - in process]
11.

Delayed-onset caspase-dependent massive hepatocyte apoptosis upon Fas activation in Bak/Bax-deficient mice.

Hikita H, Takehara T, Kodama T, Shimizu S, Shigekawa M, Hosui A, Miyagi T, Tatsumi T, Ishida H, Li W, Kanto T, Hiramatsu N, Shimizu S, Tsujimoto Y, Hayashi N.

Hepatology. 2011 Jul;54(1):240-51. doi: 10.1002/hep.24305. Epub 2011 Apr 11.

PMID:
21425311
[PubMed - indexed for MEDLINE]
12.

Pseudomonas exotoxin A-mediated apoptosis is Bak dependent and preceded by the degradation of Mcl-1.

Du X, Youle RJ, FitzGerald DJ, Pastan I.

Mol Cell Biol. 2010 Jul;30(14):3444-52. doi: 10.1128/MCB.00813-09. Epub 2010 May 10.

PMID:
20457813
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation.

Chen S, Dai Y, Harada H, Dent P, Grant S.

Cancer Res. 2007 Jan 15;67(2):782-91.

PMID:
17234790
[PubMed - indexed for MEDLINE]
Free Article
14.

p14(ARF)-induced apoptosis in p53 protein-deficient cells is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins.

Müer A, Overkamp T, Gillissen B, Richter A, Pretzsch T, Milojkovic A, Dörken B, Daniel PT, Hemmati P.

J Biol Chem. 2012 May 18;287(21):17343-52. doi: 10.1074/jbc.M111.314898. Epub 2012 Feb 21.

PMID:
22354970
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

The multidomain proapoptotic molecules Bax and Bak are directly activated by heat.

Pagliari LJ, Kuwana T, Bonzon C, Newmeyer DD, Tu S, Beere HM, Green DR.

Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17975-80. Epub 2005 Dec 5.

PMID:
16330765
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Programmed anuclear cell death delimits platelet life span.

Mason KD, Carpinelli MR, Fletcher JI, Collinge JE, Hilton AA, Ellis S, Kelly PN, Ekert PG, Metcalf D, Roberts AW, Huang DC, Kile BT.

Cell. 2007 Mar 23;128(6):1173-86.

PMID:
17382885
[PubMed - indexed for MEDLINE]
Free Article
17.

Key role for Bak activation and Bak-Bax interaction in the apoptotic response to vinblastine.

Upreti M, Chu R, Galitovskaya E, Smart SK, Chambers TC.

Mol Cancer Ther. 2008 Jul;7(7):2224-32. doi: 10.1158/1535-7163.MCT-07-2299.

PMID:
18645031
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.

Kim H, Tu HC, Ren D, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH.

Mol Cell. 2009 Nov 13;36(3):487-99. doi: 10.1016/j.molcel.2009.09.030.

PMID:
19917256
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak.

Wang C, Youle RJ.

Oncogene. 2012 Jun 28;31(26):3177-89. doi: 10.1038/onc.2011.497. Epub 2011 Nov 7.

PMID:
22056880
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

van Delft MF, Wei AH, Mason KD, Vandenberg CJ, Chen L, Czabotar PE, Willis SN, Scott CL, Day CL, Cory S, Adams JM, Roberts AW, Huang DC.

Cancer Cell. 2006 Nov;10(5):389-99.

PMID:
17097561
[PubMed - indexed for MEDLINE]
Free PMC Article

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