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Similar articles for PubMed (Select 21875941)


Reduced level of ribonucleotide reductase R2 subunits increases dependence on homologous recombination repair of cisplatin-induced DNA damage.

Lin ZP, Lee Y, Lin F, Belcourt MF, Li P, Cory JG, Glazer PM, Sartorelli AC.

Mol Pharmacol. 2011 Dec;80(6):1000-12. doi: 10.1124/mol.111.074708. Epub 2011 Aug 29.


Excess ribonucleotide reductase R2 subunits coordinate the S phase checkpoint to facilitate DNA damage repair and recovery from replication stress.

Lin ZP, Belcourt MF, Carbone R, Eaton JS, Penketh PG, Shadel GS, Cory JG, Sartorelli AC.

Biochem Pharmacol. 2007 Mar 15;73(6):760-72. Epub 2006 Nov 23.


Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells.

Håkansson P, Hofer A, Thelander L.

J Biol Chem. 2006 Mar 24;281(12):7834-41. Epub 2006 Jan 24.


Activity of ribonucleotide reductase helps determine how cells repair DNA double strand breaks.

Burkhalter MD, Roberts SA, Havener JM, Ramsden DA.

DNA Repair (Amst). 2009 Nov 2;8(11):1258-63. doi: 10.1016/j.dnarep.2009.07.009. Epub 2009 Aug 26.


Ribonucleotide reductase inhibition enhances chemoradiosensitivity of human cervical cancers.

Kunos CA, Radivoyevitch T, Pink J, Chiu SM, Stefan T, Jacobberger J, Kinsella TJ.

Radiat Res. 2010 Nov;174(5):574-81. doi: 10.1667/RR2273.1. Epub 2010 Sep 10.


Overexpression of the R2 subunit of ribonucleotide reductase in human nasopharyngeal cancer cells reduces radiosensitivity.

Kuo ML, Hwang HS, Sosnay PR, Kunugi KA, Kinsella TJ.

Cancer J. 2003 Jul-Aug;9(4):277-85.


Homologous recombination contributes to the repair of DNA double-strand breaks induced by high-energy iron ions.

Zafar F, Seidler SB, Kronenberg A, Schild D, Wiese C.

Radiat Res. 2010 Jan;173(1):27-39. doi: 10.1667/RR1910.1.


A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage.

Tanaka H, Arakawa H, Yamaguchi T, Shiraishi K, Fukuda S, Matsui K, Takei Y, Nakamura Y.

Nature. 2000 Mar 2;404(6773):42-9.


Modulating radiation resistance by inhibiting ribonucleotide reductase in cancers with virally or mutationally silenced p53 protein.

Kunos CA, Chiu SM, Pink J, Kinsella TJ.

Radiat Res. 2009 Dec;172(6):666-76. doi: 10.1667/RR1858.1.


Cells from ERCC1-deficient mice show increased genome instability and a reduced frequency of S-phase-dependent illegitimate chromosome exchange but a normal frequency of homologous recombination.

Melton DW, Ketchen AM, Núñez F, Bonatti-Abbondandolo S, Abbondandolo A, Squires S, Johnson RT.

J Cell Sci. 1998 Feb;111 ( Pt 3):395-404.


Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage.

Pontarin G, Fijolek A, Pizzo P, Ferraro P, Rampazzo C, Pozzan T, Thelander L, Reichard PA, Bianchi V.

Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17801-6. doi: 10.1073/pnas.0808198105. Epub 2008 Nov 7.


Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells.

Guittet O, Håkansson P, Voevodskaya N, Fridd S, Gräslund A, Arakawa H, Nakamura Y, Thelander L.

J Biol Chem. 2001 Nov 2;276(44):40647-51. Epub 2001 Aug 21.


Identification and characterization of alternative promoters, transcripts and protein isoforms of zebrafish R2 gene.

Shang H, Li Q, Feng G, Cui Z.

PLoS One. 2011;6(8):e24089. doi: 10.1371/journal.pone.0024089. Epub 2011 Aug 24.


E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin.

Chimploy K, Díaz GD, Li Q, Carter O, Dashwood WM, Mathews CK, Williams DE, Bailey GS, Dashwood RH.

Int J Cancer. 2009 Nov 1;125(9):2086-94. doi: 10.1002/ijc.24559.


Dif1 controls subcellular localization of ribonucleotide reductase by mediating nuclear import of the R2 subunit.

Wu X, Huang M.

Mol Cell Biol. 2008 Dec;28(23):7156-67. doi: 10.1128/MCB.01388-08. Epub 2008 Oct 6.

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