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Results: 1 to 20 of 104

1.

Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells.

Kim KY, Stevens MV, Akter MH, Rusk SE, Huang RJ, Cohen A, Noguchi A, Springer D, Bocharov AV, Eggerman TL, Suen DF, Youle RJ, Amar M, Remaley AT, Sack MN.

J Clin Invest. 2011 Sep;121(9):3701-12. doi: 10.1172/JCI44736. Epub 2011 Aug 25.

PMID:
21865652
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissue.

Nicholls HT, Kowalski G, Kennedy DJ, Risis S, Zaffino LA, Watson N, Kanellakis P, Watt MJ, Bobik A, Bonen A, Febbraio M, Lancaster GI, Febbraio MA.

Diabetes. 2011 Apr;60(4):1100-10. doi: 10.2337/db10-1353. Epub 2011 Mar 4.

PMID:
21378177
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy.

von Coelln R, Thomas B, Andrabi SA, Lim KL, Savitt JM, Saffary R, Stirling W, Bruno K, Hess EJ, Lee MK, Dawson VL, Dawson TM.

J Neurosci. 2006 Apr 5;26(14):3685-96.

PMID:
16597723
[PubMed - indexed for MEDLINE]
Free Article
4.

Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation.

Avraham E, Rott R, Liani E, Szargel R, Engelender S.

J Biol Chem. 2007 Apr 27;282(17):12842-50. Epub 2007 Feb 27.

PMID:
17327227
[PubMed - indexed for MEDLINE]
Free Article
5.

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease.

Shimura H, Schlossmacher MG, Hattori N, Frosch MP, Trockenbacher A, Schneider R, Mizuno Y, Kosik KS, Selkoe DJ.

Science. 2001 Jul 13;293(5528):263-9. Epub 2001 Jun 28.

PMID:
11431533
[PubMed - indexed for MEDLINE]
Free Article
6.

Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.

Lu XH, Fleming SM, Meurers B, Ackerson LC, Mortazavi F, Lo V, Hernandez D, Sulzer D, Jackson GR, Maidment NT, Chesselet MF, Yang XW.

J Neurosci. 2009 Feb 18;29(7):1962-76. doi: 10.1523/JNEUROSCI.5351-08.2009.

PMID:
19228951
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

The regulatory role of α-synuclein and parkin in neuronal cell apoptosis; possible implications for the pathogenesis of Parkinson's disease.

Yasuda T, Mochizuki H.

Apoptosis. 2010 Nov;15(11):1312-21. doi: 10.1007/s10495-010-0486-8. Review.

PMID:
20221696
[PubMed - indexed for MEDLINE]
8.

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation.

Xiong H, Wang D, Chen L, Choo YS, Ma H, Tang C, Xia K, Jiang W, Ronai Z, Zhuang X, Zhang Z.

J Clin Invest. 2009 Mar;119(3):650-60. doi: 10.1172/JCI37617. Epub 2009 Feb 23.

PMID:
19229105
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease.

Lo Bianco C, Schneider BL, Bauer M, Sajadi A, Brice A, Iwatsubo T, Aebischer P.

Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17510-5. Epub 2004 Dec 2.

PMID:
15576511
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Lipid metabolism and body composition in Gclm(-/-) mice.

Kendig EL, Chen Y, Krishan M, Johansson E, Schneider SN, Genter MB, Nebert DW, Shertzer HG.

Toxicol Appl Pharmacol. 2011 Dec 15;257(3):338-48. doi: 10.1016/j.taap.2011.09.017. Epub 2011 Sep 24.

PMID:
21967773
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

[Etiology and pathogenesis of Parkinson's disease: from mitochondrial dysfunctions to familial Parkinson's disease].

Hattori N.

Rinsho Shinkeigaku. 2004 Apr-May;44(4-5):241-62. Review. Japanese.

PMID:
15287506
[PubMed - indexed for MEDLINE]
12.

Altered endocannabinoid signalling after a high-fat diet in Apoe(-/-) mice: relevance to adipose tissue inflammation, hepatic steatosis and insulin resistance.

Bartelt A, Orlando P, Mele C, Ligresti A, Toedter K, Scheja L, Heeren J, Di Marzo V.

Diabetologia. 2011 Nov;54(11):2900-10. doi: 10.1007/s00125-011-2274-6. Epub 2011 Aug 17.

PMID:
21847582
[PubMed - indexed for MEDLINE]
13.

Parkin in the regulation of fat uptake and mitochondrial biology: emerging links in the pathophysiology of Parkinson's disease.

Kim KY, Sack MN.

Curr Opin Lipidol. 2012 Jun;23(3):201-5. doi: 10.1097/MOL.0b013e328352dc5d. Review.

PMID:
22488424
[PubMed - indexed for MEDLINE]
14.

Parkin reinvents itself to regulate fatty acid metabolism by tagging CD36.

Abumrad NA, Moore DJ.

J Clin Invest. 2011 Sep;121(9):3389-92. doi: 10.1172/JCI59219. Epub 2011 Aug 25.

PMID:
21865651
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Increased efficiency of fatty acid uptake contributes to lipid accumulation in skeletal muscle of high fat-fed insulin-resistant rats.

Hegarty BD, Cooney GJ, Kraegen EW, Furler SM.

Diabetes. 2002 May;51(5):1477-84.

PMID:
11978645
[PubMed - indexed for MEDLINE]
Free Article
16.

Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson's disease, causes behavioral alterations but not neurodegeneration in mice.

Ageta-Ishihara N, Yamakado H, Morita T, Hattori S, Takao K, Miyakawa T, Takahashi R, Kinoshita M.

Mol Brain. 2013 Aug 11;6:35. doi: 10.1186/1756-6606-6-35.

PMID:
23938054
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1.

Roth JA, Singleton S, Feng J, Garrick M, Paradkar PN.

J Neurochem. 2010 Apr;113(2):454-64. doi: 10.1111/j.1471-4159.2010.06607.x. Epub 2010 Jan 20.

PMID:
20089134
[PubMed - indexed for MEDLINE]
18.

Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity.

Guo T, Jou W, Chanturiya T, Portas J, Gavrilova O, McPherron AC.

PLoS One. 2009;4(3):e4937. doi: 10.1371/journal.pone.0004937. Epub 2009 Mar 19.

PMID:
19295913
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism.

Qi L, Heredia JE, Altarejos JY, Screaton R, Goebel N, Niessen S, Macleod IX, Liew CW, Kulkarni RN, Bain J, Newgard C, Nelson M, Evans RM, Yates J, Montminy M.

Science. 2006 Jun 23;312(5781):1763-6.

PMID:
16794074
[PubMed - indexed for MEDLINE]
Free Article
20.

Absence of Tlr2 protects against high-fat diet-induced inflammation and results in greater insulin-stimulated glucose transport in cultured adipocytes.

Davis JE, Braucher DR, Walker-Daniels J, Spurlock ME.

J Nutr Biochem. 2011 Feb;22(2):136-41. doi: 10.1016/j.jnutbio.2009.12.008.

PMID:
20434320
[PubMed - indexed for MEDLINE]

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