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Results: 1 to 20 of 101

1.

Bisphosphonamidate clodronate prodrug exhibits potent anticancer activity in non-small-cell lung cancer cells.

Webster MR, Zhao M, Rudek MA, Hann CL, Freel Meyers CL.

J Med Chem. 2011 Oct 13;54(19):6647-56. doi: 10.1021/jm200521a. Epub 2011 Sep 9.

PMID:
21863853
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Bisphosphonamidate clodronate prodrug exhibits selective cytotoxic activity against melanoma cell lines.

Webster MR, Kamat C, Connis N, Zhao M, Weeraratna AT, Rudek MA, Hann CL, Freel Meyers CL.

Mol Cancer Ther. 2014 Feb;13(2):297-306. doi: 10.1158/1535-7163.MCT-13-0315. Epub 2013 Dec 5.

PMID:
24310621
[PubMed - in process]
3.

In vitro optimization of non-small cell lung cancer activity with troxacitabine, L-1,3-dioxolane-cytidine, prodrugs.

Radi M, Adema AD, Daft JR, Cho JH, Hoebe EK, Alexander LE, Peters GJ, Chu CK.

J Med Chem. 2007 May 3;50(9):2249-53. Epub 2007 Apr 10.

PMID:
17419604
[PubMed - indexed for MEDLINE]
4.

Novel prodrugs of tegafur that display improved anticancer activity and antiangiogenic properties.

Engel D, Nudelman A, Tarasenko N, Levovich I, Makarovsky I, Sochotnikov S, Tarasenko I, Rephaeli A.

J Med Chem. 2008 Jan 24;51(2):314-23. doi: 10.1021/jm7009827. Epub 2007 Dec 29.

PMID:
18163551
[PubMed - indexed for MEDLINE]
5.

Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside.

McGuigan C, Murziani P, Slusarczyk M, Gonczy B, Vande Voorde J, Liekens S, Balzarini J.

J Med Chem. 2011 Oct 27;54(20):7247-58. doi: 10.1021/jm200815w. Epub 2011 Sep 27.

PMID:
21892829
[PubMed - indexed for MEDLINE]
6.

A new cyclopamine glucuronide prodrug with improved kinetics of drug release.

Renoux B, Legigan T, Bensalma S, Chadéneau C, Muller JM, Papot S.

Org Biomol Chem. 2011 Dec 21;9(24):8459-64. doi: 10.1039/c1ob06081c. Epub 2011 Oct 31.

PMID:
22042246
[PubMed - indexed for MEDLINE]
7.

Synthesis and evaluation of water-soluble etoposide esters of malic acid as prodrugs.

Chen J, Du W.

Med Chem. 2013 Aug;9(5):740-7.

PMID:
23061567
[PubMed - indexed for MEDLINE]
8.

Heparin-paclitaxel conjugates as drug delivery system: synthesis, self-assembly property, drug release, and antitumor activity.

Wang Y, Xin D, Liu K, Zhu M, Xiang J.

Bioconjug Chem. 2009 Dec;20(12):2214-21. doi: 10.1021/bc8003809.

PMID:
19950889
[PubMed - indexed for MEDLINE]
9.

Enhanced stability and intracellular accumulation of quercetin by protection of the chemically or metabolically susceptible hydroxyl groups with a pivaloxymethyl (POM) promoiety.

Kim MK, Park KS, Lee C, Park HR, Choo H, Chong Y.

J Med Chem. 2010 Dec 23;53(24):8597-607. doi: 10.1021/jm101252m. Epub 2010 Nov 19.

PMID:
21090565
[PubMed - indexed for MEDLINE]
10.

Evaluation of a reductively activated duocarmycin prodrug against murine and human solid cancers.

Vielhauer GA, Swink M, Parelkar NK, Lajiness JP, Wolfe AL, Boger D.

Cancer Biol Ther. 2013 Jun;14(6):527-36. doi: 10.4161/cbt.24348.

PMID:
23760495
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Synthesis and biological evaluations of a monomethylauristatin E glucuronide prodrug for selective cancer chemotherapy.

Legigan T, Clarhaut J, Renoux B, Tranoy-Opalinski I, Monvoisin A, Jayle C, Alsarraf J, Thomas M, Papot S.

Eur J Med Chem. 2013 Sep;67:75-80. doi: 10.1016/j.ejmech.2013.06.037. Epub 2013 Jun 25.

PMID:
23845743
[PubMed - indexed for MEDLINE]
12.

Synthesis and biological activity of prodrug inhibitors of the thioredoxin-thioredoxin reductase system.

Wipf P, Lynch SM, Powis G, Birmingham A, Englund EE.

Org Biomol Chem. 2005 Nov 7;3(21):3880-2. Epub 2005 Sep 28.

PMID:
16240002
[PubMed - indexed for MEDLINE]
13.

Hybrid molecule from O2-(2,4-dinitrophenyl)diazeniumdiolate and oleanolic acid: a glutathione S-transferase π-activated nitric oxide prodrug with selective anti-human hepatocellular carcinoma activity and improved stability.

Fu J, Liu L, Huang Z, Lai Y, Ji H, Peng S, Tian J, Zhang Y.

J Med Chem. 2013 Jun 13;56(11):4641-55. doi: 10.1021/jm400393u. Epub 2013 May 16.

PMID:
23617697
[PubMed - indexed for MEDLINE]
14.

Enhanced cancer cell growth inhibition by dipeptide prodrugs of floxuridine: increased transporter affinity and metabolic stability.

Tsume Y, Hilfinger JM, Amidon GL.

Mol Pharm. 2008 Sep-Oct;5(5):717-27. doi: 10.1021/mp800008c. Epub 2008 Jul 25.

PMID:
18652477
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Novel N-oxide of naphthalimides as prodrug leads against hypoxic solid tumor: synthesis and biological evaluation.

Yin H, Xu Y, Qian X, Li Y, Liu J.

Bioorg Med Chem Lett. 2007 Apr 15;17(8):2166-70. Epub 2007 Feb 9.

PMID:
17331719
[PubMed - indexed for MEDLINE]
16.

Synthesis and evaluation of N-acylamino acids derivatives of triazenes. Activation by tyrosinase in human melanoma cell lines.

Monteiro AS, Almeida J, Cabral G, Severino P, Videira PA, Sousa A, Nunes R, Pereira JD, Francisco AP, Perry MJ, Mendes E.

Eur J Med Chem. 2013 Dec;70:1-9. doi: 10.1016/j.ejmech.2013.09.040. Epub 2013 Oct 2.

PMID:
24125877
[PubMed - in process]
17.

Hypoxia activated prodrugs of a 9-aza-anthrapyrazole derivative that has promising anticancer activity.

El-Dakdouki MH, Adamski N, Foster L, Hacker MP, Erhardt PW.

J Med Chem. 2011 Dec 8;54(23):8224-7. doi: 10.1021/jm200984x. Epub 2011 Nov 4.

PMID:
22011244
[PubMed - indexed for MEDLINE]
18.

Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer.

Zhao RY, Erickson HK, Leece BA, Reid EE, Goldmacher VS, Lambert JM, Chari RV.

J Med Chem. 2012 Jan 26;55(2):766-82. doi: 10.1021/jm201284m. Epub 2012 Jan 5.

PMID:
22148292
[PubMed - indexed for MEDLINE]
19.

Antineoplastic agents. 548. Synthesis of iodo- and diiodocombstatin phosphate prodrugs.

Pettit GR, Rosenberg HJ, Dixon R, Knight JC, Hamel E, Chapuis JC, Pettit RK, Hogan F, Sumner B, Ain KB, Trickey-Platt B.

J Nat Prod. 2012 Mar 23;75(3):385-93. doi: 10.1021/np200797x. Epub 2012 Feb 10.

PMID:
22324723
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Aminoferrocene-based prodrugs activated by reactive oxygen species.

Hagen H, Marzenell P, Jentzsch E, Wenz F, Veldwijk MR, Mokhir A.

J Med Chem. 2012 Jan 26;55(2):924-34. doi: 10.1021/jm2014937. Epub 2012 Jan 11.

PMID:
22185340
[PubMed - indexed for MEDLINE]

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