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Results: 1 to 20 of 98

1.

The glmS ribozyme tunes the catalytically critical pK(a) of its coenzyme glucosamine-6-phosphate.

Gong B, Klein DJ, Ferré-D'Amaré AR, Carey PR.

J Am Chem Soc. 2011 Sep 14;133(36):14188-91. doi: 10.1021/ja205185g. Epub 2011 Aug 22.

PMID:
21848325
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Deciphering the role of glucosamine-6-phosphate in the riboswitch action of glmS ribozyme.

Xin Y, Hamelberg D.

RNA. 2010 Dec;16(12):2455-63. doi: 10.1261/rna.2334110. Epub 2010 Oct 22.

PMID:
20971809
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Use of a coenzyme by the glmS ribozyme-riboswitch suggests primordial expansion of RNA chemistry by small molecules.

Ferré-D'Amaré AR.

Philos Trans R Soc Lond B Biol Sci. 2011 Oct 27;366(1580):2942-8. doi: 10.1098/rstb.2011.0131.

PMID:
21930586
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Structural and chemical basis for glucosamine 6-phosphate binding and activation of the glmS ribozyme.

Cochrane JC, Lipchock SV, Smith KD, Strobel SA.

Biochemistry. 2009 Apr 21;48(15):3239-46. doi: 10.1021/bi802069p.

PMID:
19228039
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

The glmS ribozyme: use of a small molecule coenzyme by a gene-regulatory RNA.

Ferré-D'Amaré AR.

Q Rev Biophys. 2010 Nov;43(4):423-47. doi: 10.1017/S0033583510000144. Epub 2010 Sep 8. Review.

PMID:
20822574
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

glmS Riboswitch binding to the glucosamine-6-phosphate α-anomer shifts the pKa toward neutrality.

Davis JH, Dunican BF, Strobel SA.

Biochemistry. 2011 Aug 23;50(33):7236-42. doi: 10.1021/bi200471c. Epub 2011 Jul 27.

PMID:
21770472
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Trans-acting glmS catalytic riboswitch: locked and loaded.

Tinsley RA, Furchak JR, Walter NG.

RNA. 2007 Apr;13(4):468-77. Epub 2007 Feb 5.

PMID:
17283212
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Analysis of metal ion dependence in glmS ribozyme self-cleavage and coenzyme binding.

Klawuhn K, Jansen JA, Souchek J, Soukup GA, Soukup JK.

Chembiochem. 2010 Dec 10;11(18):2567-71. doi: 10.1002/cbic.201000544.

PMID:
21108273
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Structural basis of glmS ribozyme activation by glucosamine-6-phosphate.

Klein DJ, Ferré-D'Amaré AR.

Science. 2006 Sep 22;313(5794):1752-6.

PMID:
16990543
[PubMed - indexed for MEDLINE]
Free Article
10.

Ligand requirements for glmS ribozyme self-cleavage.

McCarthy TJ, Plog MA, Floy SA, Jansen JA, Soukup JK, Soukup GA.

Chem Biol. 2005 Nov;12(11):1221-6. Erratum in: Chem Biol. 2006 Jun;13(6):683.

PMID:
16298301
[PubMed - indexed for MEDLINE]
Free Article
11.

Rapid steps in the glmS ribozyme catalytic pathway: cation and ligand requirements.

Brooks KM, Hampel KJ.

Biochemistry. 2011 Apr 5;50(13):2424-33. doi: 10.1021/bi101842u. Epub 2011 Mar 11.

PMID:
21395279
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Evidence for preorganization of the glmS ribozyme ligand binding pocket.

Hampel KJ, Tinsley MM.

Biochemistry. 2006 Jun 27;45(25):7861-71.

PMID:
16784238
[PubMed - indexed for MEDLINE]
13.

Structural investigation of the GlmS ribozyme bound to Its catalytic cofactor.

Cochrane JC, Lipchock SV, Strobel SA.

Chem Biol. 2007 Jan;14(1):97-105. Epub 2006 Dec 28.

PMID:
17196404
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

An in vitro evolved glmS ribozyme has the wild-type fold but loses coenzyme dependence.

Lau MW, Ferré-D'Amaré AR.

Nat Chem Biol. 2013 Dec;9(12):805-10. doi: 10.1038/nchembio.1360. Epub 2013 Oct 6.

PMID:
24096303
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Development and application of a high-throughput assay for glmS riboswitch activators.

Blount K, Puskarz I, Penchovsky R, Breaker R.

RNA Biol. 2006 Apr;3(2):77-81. Epub 2006 Apr 14.

PMID:
17114942
[PubMed - indexed for MEDLINE]
Free Article
16.

Requirement of helix P2.2 and nucleotide G1 for positioning the cleavage site and cofactor of the glmS ribozyme.

Klein DJ, Wilkinson SR, Been MD, Ferré-D'Amaré AR.

J Mol Biol. 2007 Oct 12;373(1):178-89. Epub 2007 Aug 10.

PMID:
17804015
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Examination of the structural and functional versatility of glmS ribozymes by using in vitro selection.

Link KH, Guo L, Breaker RR.

Nucleic Acids Res. 2006;34(17):4968-75. Epub 2006 Sep 18.

PMID:
16982640
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

The glmS ribozyme cofactor is a general acid-base catalyst.

Viladoms J, Fedor MJ.

J Am Chem Soc. 2012 Nov 21;134(46):19043-9. doi: 10.1021/ja307021f. Epub 2012 Nov 9.

PMID:
23113700
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Protonation states of the key active site residues and structural dynamics of the glmS riboswitch as revealed by molecular dynamics.

Banás P, Walter NG, Sponer J, Otyepka M.

J Phys Chem B. 2010 Jul 8;114(26):8701-12. doi: 10.1021/jp9109699.

PMID:
20536206
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Backbone and nucleobase contacts to glucosamine-6-phosphate in the glmS ribozyme.

Jansen JA, McCarthy TJ, Soukup GA, Soukup JK.

Nat Struct Mol Biol. 2006 Jun;13(6):517-23. Epub 2006 May 14.

PMID:
16699515
[PubMed - indexed for MEDLINE]
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