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Items: 1 to 20 of 131

1.

Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase.

Kawasumi M, Lemos B, Bradner JE, Thibodeau R, Kim YS, Schmidt M, Higgins E, Koo SW, Angle-Zahn A, Chen A, Levine D, Nguyen L, Heffernan TP, Longo I, Mandinova A, Lu YP, Conney AH, Nghiem P.

Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13716-21. doi: 10.1073/pnas.1111378108. Epub 2011 Aug 15.

2.

ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine.

Heffernan TP, Kawasumi M, Blasina A, Anderes K, Conney AH, Nghiem P.

J Invest Dermatol. 2009 Jul;129(7):1805-15. doi: 10.1038/jid.2008.435. Epub 2009 Feb 26.

3.

Effect of caffeine on the ATR/Chk1 pathway in the epidermis of UVB-irradiated mice.

Lu YP, Lou YR, Peng QY, Xie JG, Nghiem P, Conney AH.

Cancer Res. 2008 Apr 1;68(7):2523-9. doi: 10.1158/0008-5472.CAN-07-5955.

5.

Study of the DNA damage checkpoint using Xenopus egg extracts.

Willis J, DeStephanis D, Patel Y, Gowda V, Yan S.

J Vis Exp. 2012 Nov 5;(69):e4449. doi: 10.3791/4449.

6.

Ultrasound activates ataxia telangiectasia mutated- and rad3-related (ATR)-checkpoint kinase 1 (Chk1) pathway in human leukemia Jurkat cells.

Furusawa Y, Iizumi T, Fujiwara Y, Hassan MA, Tabuchi Y, Nomura T, Kondo T.

Ultrason Sonochem. 2012 Nov;19(6):1246-51. doi: 10.1016/j.ultsonch.2012.04.003. Epub 2012 Apr 19.

PMID:
22571845
7.

Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage.

Helt CE, Cliby WA, Keng PC, Bambara RA, O'Reilly MA.

J Biol Chem. 2005 Jan 14;280(2):1186-92. Epub 2004 Nov 8.

8.

Inhibition of ataxia telangiectasia- and Rad3-related function abrogates the in vitro and in vivo tumorigenicity of human colon cancer cells through depletion of the CD133(+) tumor-initiating cell fraction.

Gallmeier E, Hermann PC, Mueller MT, Machado JG, Ziesch A, De Toni EN, Palagyi A, Eisen C, Ellwart JW, Rivera J, Rubio-Viqueira B, Hidalgo M, Bunz F, Göke B, Heeschen C.

Stem Cells. 2011 Mar;29(3):418-29. doi: 10.1002/stem.595.

9.

Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites.

Das KC, Dashnamoorthy R.

Am J Physiol Lung Cell Mol Physiol. 2004 Jan;286(1):L87-97. Epub 2003 Sep 5.

10.

UVB-Induced p21 degradation promotes apoptosis of human keratinocytes.

Lei X, Liu B, Han W, Ming M, He YY.

Photochem Photobiol Sci. 2010 Dec;9(12):1640-8. doi: 10.1039/c0pp00244e. Epub 2010 Oct 8.

11.
12.

Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells.

Rodríguez-Bravo V, Guaita-Esteruelas S, Florensa R, Bachs O, Agell N.

Cancer Res. 2006 Sep 1;66(17):8672-9.

13.

Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation.

Gatei M, Sloper K, Sorensen C, Syljuäsen R, Falck J, Hobson K, Savage K, Lukas J, Zhou BB, Bartek J, Khanna KK.

J Biol Chem. 2003 Apr 25;278(17):14806-11. Epub 2003 Feb 14.

14.

Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.

Sarkaria JN, Busby EC, Tibbetts RS, Roos P, Taya Y, Karnitz LM, Abraham RT.

Cancer Res. 1999 Sep 1;59(17):4375-82.

15.

ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling.

Stiff T, Walker SA, Cerosaletti K, Goodarzi AA, Petermann E, Concannon P, O'Driscoll M, Jeggo PA.

EMBO J. 2006 Dec 13;25(24):5775-82. Epub 2006 Nov 23.

17.

ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress.

Myers K, Gagou ME, Zuazua-Villar P, Rodriguez R, Meuth M.

PLoS Genet. 2009 Jan;5(1):e1000324. doi: 10.1371/journal.pgen.1000324. Epub 2009 Jan 2.

18.

UV-induced ataxia-telangiectasia-mutated and Rad3-related (ATR) activation requires replication stress.

Ward IM, Minn K, Chen J.

J Biol Chem. 2004 Mar 12;279(11):9677-80. Epub 2004 Jan 23.

19.

Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase.

Lindsey-Boltz LA, Serçin O, Choi JH, Sancar A.

J Biol Chem. 2009 Nov 27;284(48):33107-14. doi: 10.1074/jbc.M109.064485. Epub 2009 Oct 14.

20.

Caffeine decreases phospho-Chk1 (Ser317) and increases mitotic cells with cyclin B1 and caspase 3 in tumors from UVB-treated mice.

Lu YP, Lou YR, Peng QY, Nghiem P, Conney AH.

Cancer Prev Res (Phila). 2011 Jul;4(7):1118-25. doi: 10.1158/1940-6207.CAPR-11-0116. Epub 2011 Apr 19.

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