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Items: 1 to 20 of 109

1.

Synthesis of purine-scaffold fluorescent probes for heat shock protein 90 with use in flow cytometry and fluorescence microscopy.

Taldone T, Gomes-DaGama EM, Zong H, Sen S, Alpaugh ML, Zatorska D, Alonso-Sabadell R, Guzman ML, Chiosis G.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5347-52. doi: 10.1016/j.bmcl.2011.07.026. Epub 2011 Jul 14.

2.

The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1.

Usmani SZ, Bona RD, Chiosis G, Li Z.

J Hematol Oncol. 2010 Oct 26;3:40. doi: 10.1186/1756-8722-3-40.

3.

Hsp90 inhibition by PU-H71 induces apoptosis through endoplasmic reticulum stress and mitochondrial pathway in cancer cells and overcomes the resistance conferred by Bcl-2.

Gallerne C, Prola A, Lemaire C.

Biochim Biophys Acta. 2013 Jun;1833(6):1356-66. doi: 10.1016/j.bbamcr.2013.02.014. Epub 2013 Feb 26.

4.

Radiosensitization of human lung cancer cells by the novel purine-scaffold Hsp90 inhibitor, PU-H71.

Segawa T, Fujii Y, Tanaka A, Bando S, Okayasu R, Ohnishi K, Kubota N.

Int J Mol Med. 2014 Mar;33(3):559-64. doi: 10.3892/ijmm.2013.1594. Epub 2013 Dec 19.

PMID:
24366006
5.

Synthesis of a red-shifted fluorescence polarization probe for Hsp90.

Moulick K, Clement CC, Aguirre J, Kim J, Kang Y, Felts S, Chiosis G.

Bioorg Med Chem Lett. 2006 Sep 1;16(17):4515-8. Epub 2006 Jun 22.

PMID:
16797988
6.

PAMAM structure-based multifunctional fluorescent conjugates for improved fluorescent labelling of biomacromolecules.

Wängler C, Moldenhauer G, Saffrich R, Knapp EM, Beijer B, Schnölzer M, Wängler B, Eisenhut M, Haberkorn U, Mier W.

Chemistry. 2008;14(27):8116-30. doi: 10.1002/chem.200800328.

PMID:
18752247
7.

Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies.

Nayar U, Lu P, Goldstein RL, Vider J, Ballon G, Rodina A, Taldone T, Erdjument-Bromage H, Chomet M, Blasberg R, Melnick A, Cerchietti L, Chiosis G, Wang YL, Cesarman E.

Blood. 2013 Oct 17;122(16):2837-47. doi: 10.1182/blood-2013-01-479972. Epub 2013 Aug 13.

8.

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models.

Caldas-Lopes E, Cerchietti L, Ahn JH, Clement CC, Robles AI, Rodina A, Moulick K, Taldone T, Gozman A, Guo Y, Wu N, de Stanchina E, White J, Gross SS, Ma Y, Varticovski L, Melnick A, Chiosis G.

Proc Natl Acad Sci U S A. 2009 May 19;106(20):8368-73. doi: 10.1073/pnas.0903392106. Epub 2009 May 5.

9.

Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.

He H, Zatorska D, Kim J, Aguirre J, Llauger L, She Y, Wu N, Immormino RM, Gewirth DT, Chiosis G.

J Med Chem. 2006 Jan 12;49(1):381-90.

PMID:
16392823
10.

Synthesis of novel fluorescent probes for the molecular chaperone Hsp90.

Llauger-Bufi L, Felts SJ, Huezo H, Rosen N, Chiosis G.

Bioorg Med Chem Lett. 2003 Nov 17;13(22):3975-8.

PMID:
14592488
11.

Nitroxide-fluorophore double probes: a potential tool for studying membrane heterogeneity by ESR and fluorescence.

Pajk S, Garvas M, Štrancar J, Pečar S.

Org Biomol Chem. 2011 Jun 7;9(11):4150-9. doi: 10.1039/c0ob01173h. Epub 2011 Apr 19.

PMID:
21505664
12.

Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes.

Taldone T, Rodina A, Dagama Gomes EM, Riolo M, Patel HJ, Alonso-Sabadell R, Zatorska D, Patel MR, Kishinevsky S, Chiosis G.

Beilstein J Org Chem. 2013 Mar 15;9:544-56. doi: 10.3762/bjoc.9.60. Print 2013.

13.

Synthesis of fluorescent probes based on the pyochelin siderophore scaffold.

Noël S, Guillon L, Schalk IJ, Mislin GL.

Org Lett. 2011 Mar 4;13(5):844-7. doi: 10.1021/ol1028173. Epub 2011 Feb 4.

PMID:
21294578
14.

New fluorogenic dyes for analysis of cellular processes by flow cytometry and confocal microscopy.

Nikolova K, Kaloyanova S, Mihaylova N, Stoitsova S, Chausheva S, Vasilev A, Lesev N, Dimitrova P, Deligeorgiev T, Tchorbanov A.

J Photochem Photobiol B. 2013 Dec 5;129:125-34. doi: 10.1016/j.jphotobiol.2013.10.010. Epub 2013 Oct 26.

PMID:
24231377
15.

Synthesis and properties of fluorescence probe for detection of peroxides in mitochondria.

Shioji K, Oyama Y, Okuma K, Nakagawa H.

Bioorg Med Chem Lett. 2010 Jul 1;20(13):3911-5. doi: 10.1016/j.bmcl.2010.05.017. Epub 2010 May 12.

PMID:
20605449
16.

The novel HSP90 inhibitor, PU-H71, suppresses glial cell activation but weakly affects clinical signs of EAE.

Lisi L, McGuire S, Sharp A, Chiosis G, Navarra P, Feinstein DL, Dello Russo C.

J Neuroimmunol. 2013 Feb 15;255(1-2):1-7. doi: 10.1016/j.jneuroim.2012.10.008. Epub 2012 Nov 2.

17.
18.

Characterization of the aminated agarose nanoparticles labeled with fluorescein isothiocyanate.

Zhang LM, Huang JY, Zhang LH, Chu B, Tang SQ.

Scanning. 2010 Nov-Dec;32(6):361-8. doi: 10.1002/sca.20205. Epub 2010 Oct 11.

PMID:
20938971
19.

Synthesis and characterization of the first fluorescent nonpeptide NPY Y1 receptor antagonist.

Schneider E, Keller M, Brennauer A, Hoefelschweiger BK, Gross D, Wolfbeis OS, Bernhardt G, Buschauer A.

Chembiochem. 2007 Nov 5;8(16):1981-8.

PMID:
17876753
20.

Fluorescent probes designed for detecting human serum albumin on the basis of its pseudo-esterase activity.

Kim SJ, Rhee HW, Park HJ, Kim HY, Kim HS, Hong JI.

Bioorg Med Chem Lett. 2013 Apr 1;23(7):2093-7. doi: 10.1016/j.bmcl.2013.01.124. Epub 2013 Feb 7.

PMID:
23453074
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