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Bcl-2 family genetic profiling reveals microenvironment-specific determinants of chemotherapeutic response.

Pritchard JR, Gilbert LA, Meacham CE, Ricks JL, Jiang H, Lauffenburger DA, Hemann MT.

Cancer Res. 2011 Sep 1;71(17):5850-8. doi: 10.1158/0008-5472.CAN-11-1014. Epub 2011 Jul 22.


Identification of expression signatures predictive of sensitivity to the Bcl-2 family member inhibitor ABT-263 in small cell lung carcinoma and leukemia/lymphoma cell lines.

Tahir SK, Wass J, Joseph MK, Devanarayan V, Hessler P, Zhang H, Elmore SW, Kroeger PE, Tse C, Rosenberg SH, Anderson MG.

Mol Cancer Ther. 2010 Mar;9(3):545-57. doi: 10.1158/1535-7163.MCT-09-0651. Epub 2010 Feb 23.


Bcl-2 family proteins: regulators of apoptosis and chemoresistance in hematologic malignancies.

Reed JC.

Semin Hematol. 1997 Oct;34(4 Suppl 5):9-19. Review.


The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute lymphoblastic leukemia resulting in synergistic in vitro and in vivo interactions with established drugs.

High LM, Szymanska B, Wilczynska-Kalak U, Barber N, O'Brien R, Khaw SL, Vikstrom IB, Roberts AW, Lock RB.

Mol Pharmacol. 2010 Mar;77(3):483-94. doi: 10.1124/mol.109.060780. Epub 2009 Dec 28.


Nonlinear regulation of commitment to apoptosis by simultaneous inhibition of Bcl-2 and XIAP in leukemia and lymphoma cells.

Skommer J, Das SC, Nair A, Brittain T, Raychaudhuri S.

Apoptosis. 2011 Jun;16(6):619-26. doi: 10.1007/s10495-011-0593-1.


Defective cell death signalling along the Bcl-2 regulated apoptosis pathway compromises Treg cell development and limits their functionality in mice.

Tischner D, Gaggl I, Peschel I, Kaufmann M, Tuzlak S, Drach M, Thuille N, Villunger A, Jan Wiegers G.

J Autoimmun. 2012 Feb;38(1):59-69. doi: 10.1016/j.jaut.2011.12.008. Epub 2012 Jan 17.


Small-molecule inhibitors of Bcl-2 family proteins are able to induce tumor regression in a mouse model of pre-B-cell acute lymphocytic lymphoma.

Turner BC, Eves T, Refaeli Y.

DNA Cell Biol. 2008 Mar;27(3):133-42. doi: 10.1089/dna.2007.0675.


Imatinib enhances human melanoma cell susceptibility to TRAIL-induced cell death: Relationship to Bcl-2 family and caspase activation.

Hamaï A, Richon C, Meslin F, Faure F, Kauffmann A, Lecluse Y, Jalil A, Larue L, Avril MF, Chouaib S, Mehrpour M.

Oncogene. 2006 Dec 7;25(58):7618-34. Epub 2006 Sep 18. Erratum in: Oncogene. 2007 Feb 22;26(8):1256.


γ-Secretase inhibition promotes cell death, Noxa upregulation, and sensitization to BH3 mimetic ABT-737 in human breast cancer cells.

Séveno C, Loussouarn D, Bréchet S, Campone M, Juin P, Barillé-Nion S.

Breast Cancer Res. 2012 Jun 15;14(3):R96.


Growth inhibition and apoptosis of human B-cell lymphoma in vitro and in vivo by Bcl-2 short hairpin RNA.

Liu Y, Shen Y, Qin C, Shi Y, Rong G, Yu X.

Oncol Rep. 2013 Jan;29(1):244-52. doi: 10.3892/or.2012.2081. Epub 2012 Oct 16.


Diversity of the apoptotic response to chemotherapy in childhood leukemia.

Liu T, Raetz E, Moos PJ, Perkins SL, Bruggers CS, Smith F, Carroll WL.

Leukemia. 2002 Feb;16(2):223-32.


Apoptosis and therapy of malignant diseases of the hematopoietic system.

Gruber J, Greil R.

Int Arch Allergy Immunol. 1994 Dec;105(4):368-73. Review.


Dexamethasone-induced apoptosis in acute lymphoblastic leukemia involves differential regulation of Bcl-2 family members.

Laane E, Panaretakis T, Pokrovskaja K, Buentke E, Corcoran M, Söderhäll S, Heyman M, Mazur J, Zhivotovsky B, Porwit A, Grandér D.

Haematologica. 2007 Nov;92(11):1460-9.


Oct transcription factors mediate t(14;18) lymphoma cell survival by directly regulating bcl-2 expression.

Heckman CA, Duan H, Garcia PB, Boxer LM.

Oncogene. 2006 Feb 9;25(6):888-98.


Bcl-2 gene silencing by RNA interference inhibits the growth of the human gallbladder carcinoma cell line GBC-SD in vitro and in vivo.

Geng ZM, Zhang M, Pan XT, Wang L.

Oncol Rep. 2013 Aug;30(2):793-800. doi: 10.3892/or.2013.2539. Epub 2013 Jun 12.


Neither loss of Bik alone, nor combined loss of Bik and Noxa, accelerate murine lymphoma development or render lymphoma cells resistant to DNA damaging drugs.

Happo L, Phipson B, Smyth GK, Strasser A, Scott CL.

Cell Death Dis. 2012 May 10;3:e306. doi: 10.1038/cddis.2012.42.


BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death.

Akhtar RS, Geng Y, Klocke BJ, Latham CB, Villunger A, Michalak EM, Strasser A, Carroll SL, Roth KA.

J Neurosci. 2006 Jul 5;26(27):7257-64.


A novel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species.

Verhaegen M, Bauer JA, Martín de la Vega C, Wang G, Wolter KG, Brenner JC, Nikolovska-Coleska Z, Bengtson A, Nair R, Elder JT, Van Brocklin M, Carey TE, Bradford CR, Wang S, Soengas MS.

Cancer Res. 2006 Dec 1;66(23):11348-59.

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