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Items: 1 to 20 of 87


The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function.

Yang K, Neale G, Green DR, He W, Chi H.

Nat Immunol. 2011 Jul 17;12(9):888-97. doi: 10.1038/ni.2068.


Regulation of T-cell survival and mitochondrial homeostasis by TSC1.

O'Brien TF, Gorentla BK, Xie D, Srivatsan S, McLeod IX, He YW, Zhong XP.

Eur J Immunol. 2011 Nov;41(11):3361-70. doi: 10.1002/eji.201141411. Epub 2011 Sep 19.


Critical role of the tumor suppressor tuberous sclerosis complex 1 in dendritic cell activation of CD4 T cells by promoting MHC class II expression via IRF4 and CIITA.

Pan H, O'Brien TF, Wright G, Yang J, Shin J, Wright KL, Zhong XP.

J Immunol. 2013 Jul 15;191(2):699-707. doi: 10.4049/jimmunol.1201443. Epub 2013 Jun 17.


TSC1/2 signaling complex is essential for peripheral naïve CD8+ T cell survival and homeostasis in mice.

Zhang L, Zhang H, Li L, Xiao Y, Rao E, Miao Z, Chen H, Sun L, Li H, Liu G, Zhao Y.

PLoS One. 2012;7(2):e30592. doi: 10.1371/journal.pone.0030592. Epub 2012 Feb 21.


Monoallelic germline TSC1 mutations are permissive for T lymphocyte development and homeostasis in tuberous sclerosis complex individuals.

Pilipow K, Basso V, Migone N, Mondino A.

PLoS One. 2014 Mar 14;9(3):e91952. doi: 10.1371/journal.pone.0091952. eCollection 2014.


The tuberous sclerosis complex-mammalian target of rapamycin pathway maintains the quiescence and survival of naive T cells.

Wu Q, Liu Y, Chen C, Ikenoue T, Qiao Y, Li CS, Li W, Guan KL, Liu Y, Zheng P.

J Immunol. 2011 Aug 1;187(3):1106-12. doi: 10.4049/jimmunol.1003968. Epub 2011 Jun 27.


The role of tuberous sclerosis complex 1 in regulating innate immunity.

Pan H, O'Brien TF, Zhang P, Zhong XP.

J Immunol. 2012 Apr 15;188(8):3658-66. doi: 10.4049/jimmunol.1102187. Epub 2012 Mar 12.


Regulation of mast cell survival and function by tuberous sclerosis complex 1.

Shin J, Pan H, Zhong XP.

Blood. 2012 Apr 5;119(14):3306-14. doi: 10.1182/blood-2011-05-353342. Epub 2012 Feb 23.


mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function.

Zeng H, Yang K, Cloer C, Neale G, Vogel P, Chi H.

Nature. 2013 Jul 25;499(7459):485-90. doi: 10.1038/nature12297. Epub 2013 Jun 30.


Role of tumor suppressor TSC1 in regulating antigen-specific primary and memory CD8 T cell responses to bacterial infection.

Krishna S, Yang J, Wang H, Qiu Y, Zhong XP.

Infect Immun. 2014 Jul;82(7):3045-57. doi: 10.1128/IAI.01816-14. Epub 2014 May 12.


Cystogenesis and elongated primary cilia in Tsc1-deficient distal convoluted tubules.

Armour EA, Carson RP, Ess KC.

Am J Physiol Renal Physiol. 2012 Aug 15;303(4):F584-92. doi: 10.1152/ajprenal.00141.2012. Epub 2012 Jun 6.


iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions.

Wu J, Yang J, Yang K, Wang H, Gorentla B, Shin J, Qiu Y, Que LG, Foster WM, Xia Z, Chi H, Zhong XP.

J Clin Invest. 2014 Apr;124(4):1685-98. doi: 10.1172/JCI69780. Epub 2014 Mar 10.


Tsc1 promotes the differentiation of memory CD8+ T cells via orchestrating the transcriptional and metabolic programs.

Shrestha S, Yang K, Wei J, Karmaus PW, Neale G, Chi H.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14858-63. doi: 10.1073/pnas.1404264111. Epub 2014 Sep 30.


Tumor suppressor TSC1 is critical for T-cell anergy.

Xie DL, Wu J, Lou YL, Zhong XP.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14152-7. doi: 10.1073/pnas.1119744109. Epub 2012 Aug 13.


Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner.

Di Nardo A, Kramvis I, Cho N, Sadowski A, Meikle L, Kwiatkowski DJ, Sahin M.

J Neurosci. 2009 May 6;29(18):5926-37. doi: 10.1523/JNEUROSCI.0778-09.2009.


mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization.

Gan B, Sahin E, Jiang S, Sanchez-Aguilera A, Scott KL, Chin L, Williams DA, Kwiatkowski DJ, DePinho RA.

Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19384-9. doi: 10.1073/pnas.0810584105. Epub 2008 Dec 3.


The TSC1-TSC2 complex is required for proper activation of mTOR complex 2.

Huang J, Dibble CC, Matsuzaki M, Manning BD.

Mol Cell Biol. 2008 Jun;28(12):4104-15. doi: 10.1128/MCB.00289-08. Epub 2008 Apr 14.


Disruption of TSC1/2 signaling complex reveals a checkpoint governing thymic CD4+ CD25+ Foxp3+ regulatory T-cell development in mice.

Chen H, Zhang L, Zhang H, Xiao Y, Shao L, Li H, Yin H, Wang R, Liu G, Corley D, Yang Z, Zhao Y.

FASEB J. 2013 Oct;27(10):3979-90. doi: 10.1096/fj.13-235408. Epub 2013 Jul 23.


Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.

Zhang HH, Huang J, Düvel K, Boback B, Wu S, Squillace RM, Wu CL, Manning BD.

PLoS One. 2009 Jul 10;4(7):e6189. doi: 10.1371/journal.pone.0006189.


Canonical autophagy dependent on the class III phosphoinositide-3 kinase Vps34 is required for naive T-cell homeostasis.

Willinger T, Flavell RA.

Proc Natl Acad Sci U S A. 2012 May 29;109(22):8670-5. doi: 10.1073/pnas.1205305109. Epub 2012 May 16.

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