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Results: 1 to 20 of 88

1.

Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice.

Wang H, Venkatesh M, Li H, Goetz R, Mukherjee S, Biswas A, Zhu L, Kaubisch A, Wang L, Pullman J, Whitney K, Kuro-o M, Roig AI, Shay JW, Mohammadi M, Mani S.

J Clin Invest. 2011 Aug;121(8):3220-32. doi: 10.1172/JCI41514. Epub 2011 Jul 11.

PMID:
21747170
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Lithocholic acid induction of the FGF19 promoter in intestinal cells is mediated by PXR.

Wistuba W, Gnewuch C, Liebisch G, Schmitz G, Langmann T.

World J Gastroenterol. 2007 Aug 21;13(31):4230-5.

PMID:
17696253
[PubMed - indexed for MEDLINE]
Free Article
3.

Pregnane X receptor suppresses proliferation and tumourigenicity of colon cancer cells.

Ouyang N, Ke S, Eagleton N, Xie Y, Chen G, Laffins B, Yao H, Zhou B, Tian Y.

Br J Cancer. 2010 Jun 8;102(12):1753-61. doi: 10.1038/sj.bjc.6605677.

PMID:
20531417
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

The antiapoptotic role of pregnane X receptor in human colon cancer cells.

Zhou J, Liu M, Zhai Y, Xie W.

Mol Endocrinol. 2008 Apr;22(4):868-80. Epub 2007 Dec 20.

PMID:
18096695
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Association of pregnane X receptor with multidrug resistance-related protein 3 and its role in human colon cancer chemoresistance.

Jiang H, Chen K, He J, Pan F, Li J, Chen J, Chen W, Liang H.

J Gastrointest Surg. 2009 Oct;13(10):1831-8. doi: 10.1007/s11605-009-0964-x. Epub 2009 Jul 11.

PMID:
19593667
[PubMed - indexed for MEDLINE]
6.

Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells.

Habano W, Gamo T, Terashima J, Sugai T, Otsuka K, Wakabayashi G, Ozawa S.

BMC Cancer. 2011 Feb 22;11:81. doi: 10.1186/1471-2407-11-81.

PMID:
21342487
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models.

Desnoyers LR, Pai R, Ferrando RE, Hötzel K, Le T, Ross J, Carano R, D'Souza A, Qing J, Mohtashemi I, Ashkenazi A, French DM.

Oncogene. 2008 Jan 3;27(1):85-97. Epub 2007 Jun 25.

PMID:
17599042
[PubMed - indexed for MEDLINE]
8.

PXR-mediated induction of P-glycoprotein by anticancer drugs in a human colon adenocarcinoma-derived cell line.

Harmsen S, Meijerman I, Febus CL, Maas-Bakker RF, Beijnen JH, Schellens JH.

Cancer Chemother Pharmacol. 2010 Sep;66(4):765-71. doi: 10.1007/s00280-009-1221-4. Epub 2009 Dec 30.

PMID:
20041327
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Down-regulation of pregnane X receptor contributes to cell growth inhibition and apoptosis by anticancer agents in endometrial cancer cells.

Masuyama H, Nakatsukasa H, Takamoto N, Hiramatsu Y.

Mol Pharmacol. 2007 Oct;72(4):1045-53. Epub 2007 Jul 17.

PMID:
17636047
[PubMed - indexed for MEDLINE]
Free Article
10.

Expanding the roles for pregnane X receptor in cancer: proliferation and drug resistance in ovarian cancer.

Gupta D, Venkatesh M, Wang H, Kim S, Sinz M, Goldberg GL, Whitney K, Longley C, Mani S.

Clin Cancer Res. 2008 Sep 1;14(17):5332-40. doi: 10.1158/1078-0432.CCR-08-1033.

PMID:
18765524
[PubMed - indexed for MEDLINE]
Free Article
11.

Pregnane xenobiotic receptor in cancer pathogenesis and therapeutic response.

Pondugula SR, Mani S.

Cancer Lett. 2013 Jan 1;328(1):1-9. doi: 10.1016/j.canlet.2012.08.030. Epub 2012 Aug 29. Review.

PMID:
22939994
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Inhibition of fibroblast growth factor 19 reduces tumor growth by modulating beta-catenin signaling.

Pai R, Dunlap D, Qing J, Mohtashemi I, Hotzel K, French DM.

Cancer Res. 2008 Jul 1;68(13):5086-95. doi: 10.1158/0008-5472.CAN-07-2325.

PMID:
18593907
[PubMed - indexed for MEDLINE]
Free Article
13.

Pregnane X receptor and human malignancy.

Koutsounas I, Patsouris E, Theocharis S.

Histol Histopathol. 2013 Apr;28(4):405-20. Epub 2013 Feb 15. Review.

PMID:
23413096
[PubMed - indexed for MEDLINE]
14.

Involvement of multiple elements in FXR-mediated transcriptional activation of FGF19.

Miyata M, Hata T, Yamakawa H, Kagawa T, Yoshinari K, Yamazoe Y.

J Steroid Biochem Mol Biol. 2012 Oct;132(1-2):41-7. doi: 10.1016/j.jsbmb.2012.04.008. Epub 2012 May 3.

PMID:
22561792
[PubMed - indexed for MEDLINE]
15.
16.

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.

Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, Edwards PA.

J Biol Chem. 2002 Jan 25;277(4):2908-15. Epub 2001 Nov 12.

PMID:
11706036
[PubMed - indexed for MEDLINE]
Free Article
17.

Role of human pregnane X receptor in tamoxifen- and 4-hydroxytamoxifen-mediated CYP3A4 induction in primary human hepatocytes and LS174T cells.

Sane RS, Buckley DJ, Buckley AR, Nallani SC, Desai PB.

Drug Metab Dispos. 2008 May;36(5):946-54. doi: 10.1124/dmd.107.018598. Epub 2008 Feb 25.

PMID:
18299335
[PubMed - indexed for MEDLINE]
Free Article
18.

The glycosphingolipid globotriaosylceramide in the metastatic transformation of colon cancer.

Kovbasnjuk O, Mourtazina R, Baibakov B, Wang T, Elowsky C, Choti MA, Kane A, Donowitz M.

Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19087-92. Epub 2005 Dec 19.

PMID:
16365318
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Alleviation of gut inflammation by Cdx2/Pxr pathway in a mouse model of chemical colitis.

Dou W, Mukherjee S, Li H, Venkatesh M, Wang H, Kortagere S, Peleg A, Chilimuri SS, Wang ZT, Feng Y, Fearon ER, Mani S.

PLoS One. 2012;7(7):e36075. doi: 10.1371/journal.pone.0036075. Epub 2012 Jul 16.

PMID:
22815676
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Identification of Ginkgo biloba as a novel activator of pregnane X receptor.

Yeung EY, Sueyoshi T, Negishi M, Chang TK.

Drug Metab Dispos. 2008 Nov;36(11):2270-6. doi: 10.1124/dmd.108.023499. Epub 2008 Aug 25.

PMID:
18725505
[PubMed - indexed for MEDLINE]
Free PMC Article

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