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Items: 1 to 20 of 94

1.

PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment.

Avivar-Valderas A, Salas E, Bobrovnikova-Marjon E, Diehl JA, Nagi C, Debnath J, Aguirre-Ghiso JA.

Mol Cell Biol. 2011 Sep;31(17):3616-29. doi: 10.1128/MCB.05164-11. Epub 2011 Jun 27.

2.

Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK.

Avivar-Valderas A, Bobrovnikova-Marjon E, Alan Diehl J, Bardeesy N, Debnath J, Aguirre-Ghiso JA.

Oncogene. 2013 Oct 10;32(41):4932-40. doi: 10.1038/onc.2012.512. Epub 2012 Nov 19.

3.
4.

Antioxidant enzymes mediate survival of breast cancer cells deprived of extracellular matrix.

Davison CA, Durbin SM, Thau MR, Zellmer VR, Chapman SE, Diener J, Wathen C, Leevy WM, Schafer ZT.

Cancer Res. 2013 Jun 15;73(12):3704-15. doi: 10.1158/0008-5472.CAN-12-2482.

5.

Induction of autophagy during extracellular matrix detachment promotes cell survival.

Fung C, Lock R, Gao S, Salas E, Debnath J.

Mol Biol Cell. 2008 Mar;19(3):797-806. Epub 2007 Dec 19.

6.

The neuro-steroid, 5-androstene 3β,17α diol; induces endoplasmic reticulum stress and autophagy through PERK/eIF2α signaling in malignant glioma cells and transformed fibroblasts.

Jia W, Loria RM, Park MA, Yacoub A, Dent P, Graf MR.

Int J Biochem Cell Biol. 2010 Dec;42(12):2019-29. doi: 10.1016/j.biocel.2010.09.003. Epub 2010 Sep 18.

PMID:
20851775
7.

Detachment-induced autophagy in three-dimensional epithelial cell cultures.

Debnath J.

Methods Enzymol. 2009;452:423-39. doi: 10.1016/S0076-6879(08)03625-2.

PMID:
19200896
8.

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment.

Schafer ZT, Grassian AR, Song L, Jiang Z, Gerhart-Hines Z, Irie HY, Gao S, Puigserver P, Brugge JS.

Nature. 2009 Sep 3;461(7260):109-13. doi: 10.1038/nature08268. Epub 2009 Aug 19.

9.

Detachment-induced autophagy during anoikis and lumen formation in epithelial acini.

Debnath J.

Autophagy. 2008 Apr;4(3):351-3. Epub 2008 Jan 7.

PMID:
18196957
10.

Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling.

Pradeep CR, Köstler WJ, Lauriola M, Granit RZ, Zhang F, Jacob-Hirsch J, Rechavi G, Nair HB, Hennessy BT, Gonzalez-Angulo AM, Tekmal RR, Ben-Porath I, Mills GB, Domany E, Yarden Y.

Oncogene. 2012 Feb 16;31(7):907-17. doi: 10.1038/onc.2011.279. Epub 2011 Jul 11.

11.

Inhibition of proliferation by PERK regulates mammary acinar morphogenesis and tumor formation.

Sequeira SJ, Ranganathan AC, Adam AP, Iglesias BV, Farias EF, Aguirre-Ghiso JA.

PLoS One. 2007 Jul 18;2(7):e615.

12.

Upregulation of ATG3 contributes to autophagy induced by the detachment of intestinal epithelial cells from the extracellular matrix, but promotes autophagy-independent apoptosis of the attached cells.

Yoo BH, Zagryazhskaya A, Li Y, Koomson A, Khan IA, Sasazuki T, Shirasawa S, Rosen KV.

Autophagy. 2015;11(8):1230-46. doi: 10.1080/15548627.2015.1056968.

PMID:
26061804
13.

ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation.

Kouroku Y, Fujita E, Tanida I, Ueno T, Isoai A, Kumagai H, Ogawa S, Kaufman RJ, Kominami E, Momoi T.

Cell Death Differ. 2007 Feb;14(2):230-9. Epub 2006 Jun 23.

14.

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha.

Koumenis C, Naczki C, Koritzinsky M, Rastani S, Diehl A, Sonenberg N, Koromilas A, Wouters BG.

Mol Cell Biol. 2002 Nov;22(21):7405-16.

15.

Extracellular matrix regulation of autophagy.

Lock R, Debnath J.

Curr Opin Cell Biol. 2008 Oct;20(5):583-8. doi: 10.1016/j.ceb.2008.05.002. Epub 2008 Jun 21. Review.

16.

Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling.

Zhang G, Park MA, Mitchell C, Walker T, Hamed H, Studer E, Graf M, Rahmani M, Gupta S, Hylemon PB, Fisher PB, Grant S, Dent P.

J Biol Chem. 2008 Sep 5;283(36):24343-58. doi: 10.1074/jbc.M803444200. Epub 2008 Jul 9.

17.

PKR-like endoplasmic reticulum kinase is necessary for lipogenic activation during HCMV infection.

Yu Y, Pierciey FJ Jr, Maguire TG, Alwine JC.

PLoS Pathog. 2013;9(4):e1003266. doi: 10.1371/journal.ppat.1003266. Epub 2013 Apr 4.

18.

Endoplasmic reticulum stress response mediated by the PERK-eIF2(alpha)-ATF4 pathway is involved in osteoblast differentiation induced by BMP2.

Saito A, Ochiai K, Kondo S, Tsumagari K, Murakami T, Cavener DR, Imaizumi K.

J Biol Chem. 2011 Feb 11;286(6):4809-18. doi: 10.1074/jbc.M110.152900. Epub 2010 Dec 6.

19.

PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway.

Hamanaka RB, Bennett BS, Cullinan SB, Diehl JA.

Mol Biol Cell. 2005 Dec;16(12):5493-501. Epub 2005 Sep 21.

20.

ERp29 regulates response to doxorubicin by a PERK-mediated mechanism.

Farmaki E, Mkrtchian S, Papazian I, Papavassiliou AG, Kiaris H.

Biochim Biophys Acta. 2011 Jun;1813(6):1165-71. doi: 10.1016/j.bbamcr.2011.03.003. Epub 2011 Mar 22.

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