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Items: 1 to 20 of 142

1.

Generation of chordoma cell line JHC7 and the identification of Brachyury as a novel molecular target.

Hsu W, Mohyeldin A, Shah SR, ap Rhys CM, Johnson LF, Sedora-Roman NI, Kosztowski TA, Awad OA, McCarthy EF, Loeb DM, Wolinsky JP, Gokaslan ZL, Quiñones-Hinojosa A.

J Neurosurg. 2011 Oct;115(4):760-9. doi: 10.3171/2011.5.JNS11185. Epub 2011 Jun 24.

2.

Molecular characterization of chordoma xenografts generated from a novel primary chordoma cell source and two chordoma cell lines.

Karikari IO, Gilchrist CL, Jing L, Alcorta DA, Chen J, Richardson WJ, Gabr MA, Bell RD, Kelley MJ, Bagley CA, Setton LA.

J Neurosurg Spine. 2014 Sep;21(3):386-93. doi: 10.3171/2014.4.SPINE13262. Epub 2014 Jun 6.

3.

Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study.

Presneau N, Shalaby A, Ye H, Pillay N, Halai D, Idowu B, Tirabosco R, Whitwell D, Jacques TS, Kindblom LG, Brüderlein S, Möller P, Leithner A, Liegl B, Amary FM, Athanasou NN, Hogendoorn PC, Mertens F, Szuhai K, Flanagan AM.

J Pathol. 2011 Feb;223(3):327-35. doi: 10.1002/path.2816. Epub 2010 Nov 24.

PMID:
21171078
4.

Diagnosing an extra-axial chordoma of the proximal tibia with the help of brachyury, a molecule required for notochordal differentiation.

O'donnell P, Tirabosco R, Vujovic S, Bartlett W, Briggs TW, Henderson S, Boshoff C, Flanagan AM.

Skeletal Radiol. 2007 Jan;36(1):59-65. Epub 2006 Jun 30.

PMID:
16810540
5.

Molecular and clinical risk factors for recurrence of skull base chordomas: gain on chromosome 2p, expression of brachyury, and lack of irradiation negatively correlate with patient prognosis.

Kitamura Y, Sasaki H, Kimura T, Miwa T, Takahashi S, Kawase T, Yoshida K.

J Neuropathol Exp Neurol. 2013 Sep;72(9):816-23. doi: 10.1097/NEN.0b013e3182a065d0.

6.

From notochord formation to hereditary chordoma: the many roles of Brachyury.

Nibu Y, José-Edwards DS, Di Gregorio A.

Biomed Res Int. 2013;2013:826435. doi: 10.1155/2013/826435. Epub 2013 Mar 31. Review.

7.

An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma.

Nelson AC, Pillay N, Henderson S, Presneau N, Tirabosco R, Halai D, Berisha F, Flicek P, Stemple DL, Stern CD, Wardle FC, Flanagan AM.

J Pathol. 2012 Nov;228(3):274-85. doi: 10.1002/path.4082. Epub 2012 Sep 26.

PMID:
22847733
8.

Classic chordoma coexisting with benign notochordal cell rest demonstrating different immunohistological expression patterns of brachyury and galectin-3.

Shen J, Li CD, Yang HL, Lu J, Zou TM, Wang DL, Deng M.

J Clin Neurosci. 2011 Jan;18(1):96-9. doi: 10.1016/j.jocn.2010.03.066. Epub 2010 Sep 19.

PMID:
20855213
9.

Brachyury expression in extra-axial skeletal and soft tissue chordomas: a marker that distinguishes chordoma from mixed tumor/myoepithelioma/parachordoma in soft tissue.

Tirabosco R, Mangham DC, Rosenberg AE, Vujovic S, Bousdras K, Pizzolitto S, De Maglio G, den Bakker MA, Di Francesco L, Kalil RK, Athanasou NA, O'Donnell P, McCarthy EF, Flanagan AM.

Am J Surg Pathol. 2008 Apr;32(4):572-80. doi: 10.1097/PAS.0b013e31815b693a.

PMID:
18301055
10.

The FGFR/MEK/ERK/brachyury pathway is critical for chordoma cell growth and survival.

Hu Y, Mintz A, Shah SR, Quinones-Hinojosa A, Hsu W.

Carcinogenesis. 2014 Jul;35(7):1491-9. doi: 10.1093/carcin/bgu014. Epub 2014 Jan 20.

11.

Establishment and characterization of a primary human chordoma xenograft model.

Siu IM, Salmasi V, Orr BA, Zhao Q, Binder ZA, Tran C, Ishii M, Riggins GJ, Hann CL, Gallia GL.

J Neurosurg. 2012 Apr;116(4):801-9. doi: 10.3171/2011.12.JNS111123. Epub 2012 Jan 27.

12.

The T-box transcription factor Brachyury regulates epithelial-mesenchymal transition in association with cancer stem-like cells in adenoid cystic carcinoma cells.

Shimoda M, Sugiura T, Imajyo I, Ishii K, Chigita S, Seki K, Kobayashi Y, Shirasuna K.

BMC Cancer. 2012 Aug 29;12:377. doi: 10.1186/1471-2407-12-377.

13.

T gene isoform expression pattern is significantly different between chordomas and notochords.

Wang K, Hu Q, Wang L, Chen W, Tian K, Cao C, Wu Z, Jia G, Zhang L, Zeng C, Zhang J.

Biochem Biophys Res Commun. 2015 Nov 13;467(2):261-7. doi: 10.1016/j.bbrc.2015.09.178. Epub 2015 Oct 3.

PMID:
26435504
14.

Analysis of the fibroblastic growth factor receptor-RAS/RAF/MEK/ERK-ETS2/brachyury signalling pathway in chordomas.

Shalaby AA, Presneau N, Idowu BD, Thompson L, Briggs TR, Tirabosco R, Diss TC, Flanagan AM.

Mod Pathol. 2009 Aug;22(8):996-1005. doi: 10.1038/modpathol.2009.63. Epub 2009 May 1.

15.

Novel therapeutic targets in chordoma.

Bydon M, Papadimitriou K, Witham T, Wolinsky JP, Bydon A, Sciubba D, Gokaslan Z.

Expert Opin Ther Targets. 2012 Nov;16(11):1139-43. doi: 10.1517/14728222.2012.714772. Epub 2012 Aug 4. Review.

PMID:
22860993
16.

[Novel molecular aspects of chordomas].

Scheil-Bertram S.

Pathologe. 2014 Nov;35 Suppl 2:237-41. doi: 10.1007/s00292-014-1986-z. German.

PMID:
25394972
17.

Tissue microarray immunohistochemical detection of brachyury is not a prognostic indicator in chordoma.

Zhang L, Guo S, Schwab JH, Nielsen GP, Choy E, Ye S, Zhang Z, Mankin H, Hornicek FJ, Duan Z.

PLoS One. 2013 Sep 23;8(9):e75851. doi: 10.1371/journal.pone.0075851. eCollection 2013.

18.

Brachyury: a diagnostic marker for the differential diagnosis of chordoma and hemangioblastoma versus neoplastic histological mimickers.

Barresi V, Ieni A, Branca G, Tuccari G.

Dis Markers. 2014;2014:514753. doi: 10.1155/2014/514753. Epub 2014 Jan 21. Review.

19.

Specificity of brachyury in the distinction of chordoma from clear cell renal cell carcinoma and germ cell tumors: a study of 305 cases.

Sangoi AR, Karamchandani J, Lane B, Higgins JP, Rouse RV, Brooks JD, McKenney JK.

Mod Pathol. 2011 Mar;24(3):425-9. doi: 10.1038/modpathol.2010.196. Epub 2010 Nov 19.

20.

Histological study of chordoma origin from fetal notochordal cell rests.

Shen J, Shi Q, Lu J, Wang DL, Zou TM, Yang HL, Zhu GQ.

Spine (Phila Pa 1976). 2013 Dec 1;38(25):2165-70. doi: 10.1097/BRS.0000000000000010.

PMID:
24296480
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