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Results: 1 to 20 of 109

1.

Mechanisms for the evolution of a derived function in the ancestral glucocorticoid receptor.

Carroll SM, Ortlund EA, Thornton JW.

PLoS Genet. 2011 Jun;7(6):e1002117. doi: 10.1371/journal.pgen.1002117. Epub 2011 Jun 16.

PMID:
21698144
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Crystal structure of an ancient protein: evolution by conformational epistasis.

Ortlund EA, Bridgham JT, Redinbo MR, Thornton JW.

Science. 2007 Sep 14;317(5844):1544-8. Epub 2007 Aug 16.

PMID:
17702911
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Evolution of hormone selectivity in glucocorticoid and mineralocorticoid receptors.

Baker ME, Funder JW, Kattoula SR.

J Steroid Biochem Mol Biol. 2013 Sep;137:57-70. doi: 10.1016/j.jsbmb.2013.07.009. Epub 2013 Jul 29. Review. Erratum in: J Steroid Biochem Mol Biol. 2014 Jan;139:104.

PMID:
23907018
[PubMed - indexed for MEDLINE]
4.

An epistatic ratchet constrains the direction of glucocorticoid receptor evolution.

Bridgham JT, Ortlund EA, Thornton JW.

Nature. 2009 Sep 24;461(7263):515-9. doi: 10.1038/nature08249.

PMID:
19779450
[PubMed - indexed for MEDLINE]
5.

Valine 571 functions as a regional organizer in programming the glucocorticoid receptor for differential binding of glucocorticoids and mineralocorticoids.

Lind U, Greenidge P, Gustafsson JA, Wright AP, Carlstedt-Duke J.

J Biol Chem. 1999 Jun 25;274(26):18515-23.

PMID:
10373460
[PubMed - indexed for MEDLINE]
Free Article
6.

Vestigialization of an allosteric switch: genetic and structural mechanisms for the evolution of constitutive activity in a steroid hormone receptor.

Bridgham JT, Keay J, Ortlund EA, Thornton JW.

PLoS Genet. 2014 Jan;10(1):e1004058. doi: 10.1371/journal.pgen.1004058. Epub 2014 Jan 9.

PMID:
24415950
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Structural and evolutionary analysis of the co-activator binding domain in vertebrate progesterone receptors.

Kattoula SR, Baker ME.

J Steroid Biochem Mol Biol. 2014 May;141:7-15. doi: 10.1016/j.jsbmb.2013.12.018. Epub 2013 Dec 31.

PMID:
24388949
[PubMed - indexed for MEDLINE]
8.

Functional analysis of R651 mutations in the putative helix 6 of rat glucocorticoid receptors.

Huang Y, Simons SS Jr.

Mol Cell Endocrinol. 1999 Dec 20;158(1-2):117-30.

PMID:
10630412
[PubMed - indexed for MEDLINE]
9.

Evidence for a divergence in function between two glucocorticoid receptors from a basal teleost.

Li Y, Sturm A, Cunningham P, Bury NR.

BMC Evol Biol. 2012 Aug 3;12:137.

PMID:
22862956
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Evolution of ligand specificity in vertebrate corticosteroid receptors.

Arterbery AS, Fergus DJ, Fogarty EA, Mayberry J, Deitcher DL, Lee Kraus W, Bass AH.

BMC Evol Biol. 2011 Jan 14;11:14. doi: 10.1186/1471-2148-11-14.

PMID:
21232159
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Distinct interaction of cortivazol with the ligand binding domain confers glucocorticoid receptor specificity: cortivazol is a specific ligand for the glucocorticoid receptor.

Yoshikawa N, Makino Y, Okamoto K, Morimoto C, Makino I, Tanaka H.

J Biol Chem. 2002 Feb 15;277(7):5529-40. Epub 2001 Dec 10.

PMID:
11741935
[PubMed - indexed for MEDLINE]
Free Article
12.

Evolution of hormone signaling in elasmobranchs by exploitation of promiscuous receptors.

Carroll SM, Bridgham JT, Thornton JW.

Mol Biol Evol. 2008 Dec;25(12):2643-52. doi: 10.1093/molbev/msn204. Epub 2008 Sep 17.

PMID:
18799714
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Analysis of the hormone-binding domain of steroid receptors using chimeras generated by homologous recombination.

Martinez ED, Pattabiraman N, Danielsen M.

Exp Cell Res. 2005 Aug 15;308(2):320-33.

PMID:
15936754
[PubMed - indexed for MEDLINE]
14.

Evolution of glucocorticoid receptors with different glucocorticoid sensitivity.

Stolte EH, van Kemenade BM, Savelkoul HF, Flik G.

J Endocrinol. 2006 Jul;190(1):17-28. Review.

PMID:
16837607
[PubMed - indexed for MEDLINE]
Free Article
15.

Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors.

Harms MJ, Eick GN, Goswami D, Colucci JK, Griffin PR, Ortlund EA, Thornton JW.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11475-80. doi: 10.1073/pnas.1303930110. Epub 2013 Jun 24.

PMID:
23798447
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Structural analysis of the evolution of steroid specificity in the mineralocorticoid and glucocorticoid receptors.

Baker ME, Chandsawangbhuwana C, Ollikainen N.

BMC Evol Biol. 2007 Feb 16;7:24.

PMID:
17306029
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Historical contingency and its biophysical basis in glucocorticoid receptor evolution.

Harms MJ, Thornton JW.

Nature. 2014 Aug 14;512(7513):203-7. doi: 10.1038/nature13410. Epub 2014 Jun 15.

PMID:
24930765
[PubMed - in process]
18.

Identification of amino acids in the tau 2-region of the mouse glucocorticoid receptor that contribute to hormone binding and transcriptional activation.

Milhon J, Lee S, Kohli K, Chen D, Hong H, Stallcup MR.

Mol Endocrinol. 1997 Nov;11(12):1795-805.

PMID:
9369447
[PubMed - indexed for MEDLINE]
19.

Inhibition of mineralocorticoid and glucocorticoid receptor function by the heat shock protein 90-binding agent geldanamycin.

Bamberger CM, Wald M, Bamberger AM, Schulte HM.

Mol Cell Endocrinol. 1997 Aug 8;131(2):233-40.

PMID:
9296382
[PubMed - indexed for MEDLINE]

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