Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 87

1.

Design, synthesis and characterization of a highly effective inhibitor for analog-sensitive (as) kinases.

Klein M, Morillas M, Vendrell A, Brive L, Gebbia M, Wallace IM, Giaever G, Nislow C, Posas F, Grøtli M.

PLoS One. 2011;6(6):e20789. doi: 10.1371/journal.pone.0020789. Epub 2011 Jun 17.

PMID:
21698101
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Design, synthesis, and characterization of a highly effective Hog1 inhibitor: a powerful tool for analyzing MAP kinase signaling in yeast.

Dinér P, Veide Vilg J, Kjellén J, Migdal I, Andersson T, Gebbia M, Giaever G, Nislow C, Hohmann S, Wysocki R, Tamás MJ, Grøtli M.

PLoS One. 2011;6(5):e20012. doi: 10.1371/journal.pone.0020012. Epub 2011 May 31.

PMID:
21655328
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology.

Zhang C, Lopez MS, Dar AC, Ladow E, Finkbeiner S, Yun CH, Eck MJ, Shokat KM.

ACS Chem Biol. 2013 Sep 20;8(9):1931-8. doi: 10.1021/cb400376p. Epub 2013 Jul 23.

PMID:
23841803
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

A chemical switch for inhibitor-sensitive alleles of any protein kinase.

Bishop AC, Ubersax JA, Petsch DT, Matheos DP, Gray NS, Blethrow J, Shimizu E, Tsien JZ, Schultz PG, Rose MD, Wood JL, Morgan DO, Shokat KM.

Nature. 2000 Sep 21;407(6802):395-401.

PMID:
11014197
[PubMed - indexed for MEDLINE]
5.

Design and use of analog-sensitive protein kinases.

Blethrow J, Zhang C, Shokat KM, Weiss EL.

Curr Protoc Mol Biol. 2004 May;Chapter 18:Unit 18.11. doi: 10.1002/0471142727.mb1811s66.

PMID:
18265343
[PubMed - indexed for MEDLINE]
6.

Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk).

Mott BT, Tanega C, Shen M, Maloney DJ, Shinn P, Leister W, Marugan JJ, Inglese J, Austin CP, Misteli T, Auld DS, Thomas CJ.

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6700-5. doi: 10.1016/j.bmcl.2009.09.121. Epub 2009 Oct 3.

PMID:
19837585
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

NMS-P937, a 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivative as potent and selective Polo-like kinase 1 inhibitor.

Beria I, Bossi RT, Brasca MG, Caruso M, Ceccarelli W, Fachin G, Fasolini M, Forte B, Fiorentini F, Pesenti E, Pezzetta D, Posteri H, Scolaro A, Re Depaolini S, Valsasina B.

Bioorg Med Chem Lett. 2011 May 15;21(10):2969-74. doi: 10.1016/j.bmcl.2011.03.054. Epub 2011 Mar 21.

PMID:
21470862
[PubMed - indexed for MEDLINE]
8.

Design, synthesis, and biological evaluation of novel disubstituted dibenzosuberones as highly potent and selective inhibitors of p38 mitogen activated protein kinase.

Koeberle SC, Fischer S, Schollmeyer D, Schattel V, Grütter C, Rauh D, Laufer SA.

J Med Chem. 2012 Jun 28;55(12):5868-77. doi: 10.1021/jm300327h. Epub 2012 Jun 15.

PMID:
22676210
[PubMed - indexed for MEDLINE]
9.

Design and synthesis of Rho kinase inhibitors (II).

Iwakubo M, Takami A, Okada Y, Kawata T, Tagami Y, Ohashi H, Sato M, Sugiyama T, Fukushima K, Iijima H.

Bioorg Med Chem. 2007 Jan 1;15(1):350-64. Epub 2006 Oct 12.

PMID:
17046269
[PubMed - indexed for MEDLINE]
10.

Synthesis and structure based optimization of 2-(4-phenoxybenzoyl)-5-hydroxyindole as a novel CaMKII inhibitor.

Komiya M, Asano S, Koike N, Koga E, Igarashi J, Nakatani S, Isobe Y.

Bioorg Med Chem. 2012 Dec 1;20(23):6840-7. doi: 10.1016/j.bmc.2012.09.048. Epub 2012 Oct 2.

PMID:
23088910
[PubMed - indexed for MEDLINE]
11.

SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors.

Heron NM, Anderson M, Blowers DP, Breed J, Eden JM, Green S, Hill GB, Johnson T, Jung FH, McMiken HH, Mortlock AA, Pannifer AD, Pauptit RA, Pink J, Roberts NJ, Rowsell S.

Bioorg Med Chem Lett. 2006 Mar 1;16(5):1320-3. Epub 2005 Dec 5.

PMID:
16337122
[PubMed - indexed for MEDLINE]
12.

Design, synthesis, and evaluation of novel 4-thiazolylimidazoles as inhibitors of transforming growth factor-β type I receptor kinase.

Amada H, Sekiguchi Y, Ono N, Matsunaga Y, Koami T, Asanuma H, Shiozawa F, Endo M, Ikeda A, Aoki M, Fujimoto N, Wada R, Sato M.

Bioorg Med Chem Lett. 2012 Mar 1;22(5):2024-9. doi: 10.1016/j.bmcl.2012.01.066. Epub 2012 Jan 28.

PMID:
22325945
[PubMed - indexed for MEDLINE]
13.

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM.

Hickson I, Zhao Y, Richardson CJ, Green SJ, Martin NM, Orr AI, Reaper PM, Jackson SP, Curtin NJ, Smith GC.

Cancer Res. 2004 Dec 15;64(24):9152-9.

PMID:
15604286
[PubMed - indexed for MEDLINE]
Free Article
14.

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity.

Islam I, Bryant J, Chou YL, Kochanny MJ, Lee W, Phillips GB, Yu H, Adler M, Whitlow M, Ho E, Lentz D, Polokoff MA, Subramanyam B, Wu JM, Zhu D, Feldman RI, Arnaiz DO.

Bioorg Med Chem Lett. 2007 Jul 15;17(14):3814-8. Epub 2007 Apr 27.

PMID:
17531483
[PubMed - indexed for MEDLINE]
15.

Pyrazolo[4,3-d]pyrimidine bioisostere of roscovitine: evaluation of a novel selective inhibitor of cyclin-dependent kinases with antiproliferative activity.

Jorda R, Havlícek L, McNae IW, Walkinshaw MD, Voller J, Sturc A, Navrátilová J, Kuzma M, Mistrík M, Bártek J, Strnad M, Krystof V.

J Med Chem. 2011 Apr 28;54(8):2980-93. doi: 10.1021/jm200064p. Epub 2011 Apr 6.

PMID:
21417417
[PubMed - indexed for MEDLINE]
16.

[Progress in the design of selective ATP-competitive kinase inhibitors].

Deng XQ, Xiang ML, Jia R, Yang SY.

Yao Xue Xue Bao. 2007 Dec;42(12):1232-6. Review. Chinese.

PMID:
18338633
[PubMed - indexed for MEDLINE]
17.

Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of cyclin D1-CDK4: synthesis, biological evaluation and structure-activity relationships. Part 2.

Horiuchi T, Nagata M, Kitagawa M, Akahane K, Uoto K.

Bioorg Med Chem. 2009 Dec 1;17(23):7850-60. doi: 10.1016/j.bmc.2009.10.039. Epub 2009 Oct 24.

PMID:
19889545
[PubMed - indexed for MEDLINE]
18.

Design, synthesis and biological evaluation of new potent and highly selective ROS1-tyrosine kinase inhibitor.

Park BS, El-Deeb IM, Yoo KH, Oh CH, Cho SJ, Han DK, Lee HS, Lee JY, Lee SH.

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4720-3. doi: 10.1016/j.bmcl.2009.06.066. Epub 2009 Jun 21.

PMID:
19596575
[PubMed - indexed for MEDLINE]
19.

Design of allele-specific inhibitors to probe protein kinase signaling.

Bishop AC, Shah K, Liu Y, Witucki L, Kung C, Shokat KM.

Curr Biol. 1998 Feb 26;8(5):257-66.

PMID:
9501066
[PubMed - indexed for MEDLINE]
Free Article
20.

Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding.

Emmitte KA, Adjabeng GM, Andrews CW, Alberti JG, Bambal R, Chamberlain SD, Davis-Ward RG, Dickson HD, Hassler DF, Hornberger KR, Jackson JR, Kuntz KW, Lansing TJ, Mook RA Jr, Nailor KE, Pobanz MA, Smith SC, Sung CM, Cheung M.

Bioorg Med Chem Lett. 2009 Mar 15;19(6):1694-7. doi: 10.1016/j.bmcl.2009.01.094. Epub 2009 Jan 31. Erratum in: Bioorg Med Chem Lett. 2009 May 1;19(9):2604. Adjebang, George M [corrected to Adjabeng, George M].

PMID:
19237286
[PubMed - indexed for MEDLINE]
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk