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Items: 1 to 20 of 111


Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.

Huang R, Xia M, Cho MH, Sakamuru S, Shinn P, Houck KA, Dix DJ, Judson RS, Witt KL, Kavlock RJ, Tice RR, Austin CP.

Environ Health Perspect. 2011 Aug;119(8):1142-8. doi: 10.1289/ehp.1002952. Epub 2011 May 4.


Compound profiling using a panel of steroid hormone receptor cell-based assays.

Wilkinson JM, Hayes S, Thompson D, Whitney P, Bi K.

J Biomol Screen. 2008 Sep;13(8):755-65. doi: 10.1177/1087057108322155. Epub 2008 Aug 27.


Endocrine profiling and prioritization of environmental chemicals using ToxCast data.

Reif DM, Martin MT, Tan SW, Houck KA, Judson RS, Richard AM, Knudsen TB, Dix DJ, Kavlock RJ.

Environ Health Perspect. 2010 Dec;118(12):1714-20. doi: 10.1289/ehp.1002180. Epub 2010 Sep 8.


Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway.

Huang R, Sakamuru S, Martin MT, Reif DM, Judson RS, Houck KA, Casey W, Hsieh JH, Shockley KR, Ceger P, Fostel J, Witt KL, Tong W, Rotroff DM, Zhao T, Shinn P, Simeonov A, Dix DJ, Austin CP, Kavlock RJ, Tice RR, Xia M.

Sci Rep. 2014 Jul 11;4:5664. doi: 10.1038/srep05664.


Peroxisome proliferator-activated receptors and retinoid X receptor-alpha in term human gestational tissues: tissue specific and labour-associated changes.

Holdsworth-Carson SJ, Permezel M, Riley C, Rice GE, Lappas M.

Placenta. 2009 Feb;30(2):176-86. doi: 10.1016/j.placenta.2008.11.013. Epub 2008 Dec 13.


Hierarchical dose-response modeling for high-throughput toxicity screening of environmental chemicals.

Wilson A, Reif DM, Reich BJ.

Biometrics. 2014 Mar;70(1):237-46. doi: 10.1111/biom.12114. Epub 2014 Jan 7.


The ToxCast program for prioritizing toxicity testing of environmental chemicals.

Dix DJ, Houck KA, Martin MT, Richard AM, Setzer RW, Kavlock RJ.

Toxicol Sci. 2007 Jan;95(1):5-12. Epub 2006 Sep 8.


Nuclear hormone receptor activity of polybrominated diphenyl ethers and their hydroxylated and methoxylated metabolites in transactivation assays using Chinese hamster ovary cells.

Kojima H, Takeuchi S, Uramaru N, Sugihara K, Yoshida T, Kitamura S.

Environ Health Perspect. 2009 Aug;117(8):1210-8. doi: 10.1289/ehp.0900753. Epub 2009 Apr 28.


T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities.

Lee G, Elwood F, McNally J, Weiszmann J, Lindstrom M, Amaral K, Nakamura M, Miao S, Cao P, Learned RM, Chen JL, Li Y.

J Biol Chem. 2002 May 31;277(22):19649-57. Epub 2002 Mar 4.


Cloning and expression pattern of peroxisome proliferator-activated receptors, estrogen receptor alpha and retinoid X receptor alpha in the thicklip grey mullet Chelon labrosus.

Raingeard D, Cancio I, Cajaraville MP.

Comp Biochem Physiol C Toxicol Pharmacol. 2009 Jan;149(1):26-35. doi: 10.1016/j.cbpc.2008.06.005. Epub 2008 Jun 21.


Using nuclear receptor activity to stratify hepatocarcinogens.

Shah I, Houck K, Judson RS, Kavlock RJ, Martin MT, Reif DM, Wambaugh J, Dix DJ.

PLoS One. 2011 Feb 14;6(2):e14584. doi: 10.1371/journal.pone.0014584.


Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation.

Mencarelli A, Distrutti E, Renga B, D'Amore C, Cipriani S, Palladino G, Donini A, Ricci P, Fiorucci S.

PLoS One. 2011;6(7):e22978. doi: 10.1371/journal.pone.0022978. Epub 2011 Jul 29.


Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662.

Leesnitzer LM, Parks DJ, Bledsoe RK, Cobb JE, Collins JL, Consler TG, Davis RG, Hull-Ryde EA, Lenhard JM, Patel L, Plunket KD, Shenk JL, Stimmel JB, Therapontos C, Willson TM, Blanchard SG.

Biochemistry. 2002 May 28;41(21):6640-50.


In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project.

Judson RS, Houck KA, Kavlock RJ, Knudsen TB, Martin MT, Mortensen HM, Reif DM, Rotroff DM, Shah I, Richard AM, Dix DJ.

Environ Health Perspect. 2010 Apr;118(4):485-92. doi: 10.1289/ehp.0901392.


Development of androgen- and estrogen-responsive bioassays, members of a panel of human cell line-based highly selective steroid-responsive bioassays.

Sonneveld E, Jansen HJ, Riteco JA, Brouwer A, van der Burg B.

Toxicol Sci. 2005 Jan;83(1):136-48. Epub 2004 Oct 13.


Peroxisome proliferator-activated receptor γ is a target for halogenated analogs of bisphenol A.

Riu A, Grimaldi M, le Maire A, Bey G, Phillips K, Boulahtouf A, Perdu E, Zalko D, Bourguet W, Balaguer P.

Environ Health Perspect. 2011 Sep;119(9):1227-32. doi: 10.1289/ehp.1003328. Epub 2011 May 11.


Type II nuclear hormone receptors, coactivator, and target gene repression in adipose tissue in the acute-phase response.

Lu B, Moser AH, Shigenaga JK, Feingold KR, Grunfeld C.

J Lipid Res. 2006 Oct;47(10):2179-90. Epub 2006 Jul 17.

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