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Results: 1 to 20 of 136

1.

Mitochondria-targeted ubiquinone (MitoQ) decreases ethanol-dependent micro and macro hepatosteatosis.

Chacko BK, Srivastava A, Johnson MS, Benavides GA, Chang MJ, Ye Y, Jhala N, Murphy MP, Kalyanaraman B, Darley-Usmar VM.

Hepatology. 2011 Jul;54(1):153-63. doi: 10.1002/hep.24377.

PMID:
21520201
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/-/ApoE-/- mice.

Mercer JR, Yu E, Figg N, Cheng KK, Prime TA, Griffin JL, Masoodi M, Vidal-Puig A, Murphy MP, Bennett MR.

Free Radic Biol Med. 2012 Mar 1;52(5):841-9. doi: 10.1016/j.freeradbiomed.2011.11.026. Epub 2011 Dec 14.

PMID:
22210379
[PubMed - indexed for MEDLINE]
3.

Role of medium-chain triglycerides in the alcohol-mediated cytochrome P450 2E1 induction of mitochondria.

Lieber CS, Cao Q, DeCarli LM, Leo MA, Mak KM, Ponomarenko A, Ren C, Wang X.

Alcohol Clin Exp Res. 2007 Oct;31(10):1660-8. Epub 2007 Aug 6.

PMID:
17681033
[PubMed - indexed for MEDLINE]
4.

Additive effects of mitochondrion-targeted cytochrome CYP2E1 and alcohol toxicity on cytochrome c oxidase function and stability of respirosome complexes.

Bansal S, Srinivasan S, Anandasadagopan S, Chowdhury AR, Selvaraj V, Kalyanaraman B, Joseph J, Avadhani NG.

J Biol Chem. 2012 May 4;287(19):15284-97. doi: 10.1074/jbc.M111.314062. Epub 2012 Mar 6.

PMID:
22396533
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1α in vivo.

Wang X, Wu D, Yang L, Gan L, Cederbaum AI.

Free Radic Biol Med. 2013 Oct;63:175-86. doi: 10.1016/j.freeradbiomed.2013.05.009. Epub 2013 May 10.

PMID:
23669278
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis.

Abdelmegeed MA, Banerjee A, Jang S, Yoo SH, Yun JW, Gonzalez FJ, Keshavarzian A, Song BJ.

Free Radic Biol Med. 2013 Dec;65:1238-45. doi: 10.1016/j.freeradbiomed.2013.09.009. Epub 2013 Sep 21.

PMID:
24064383
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Protective efficacy of mitochondrial targeted antioxidant MitoQ against dichlorvos induced oxidative stress and cell death in rat brain.

Wani WY, Gudup S, Sunkaria A, Bal A, Singh PP, Kandimalla RJ, Sharma DR, Gill KD.

Neuropharmacology. 2011 Dec;61(8):1193-201. doi: 10.1016/j.neuropharm.2011.07.008. Epub 2011 Jul 26.

PMID:
21784090
[PubMed - indexed for MEDLINE]
8.

Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines.

Dashdorj A, Jyothi KR, Lim S, Jo A, Nguyen MN, Ha J, Yoon KS, Kim HJ, Park JH, Murphy MP, Kim SS.

BMC Med. 2013 Aug 6;11:178. doi: 10.1186/1741-7015-11-178.

PMID:
23915129
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

The mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease.

Ng LF, Gruber J, Cheah IK, Goo CK, Cheong WF, Shui G, Sit KP, Wenk MR, Halliwell B.

Free Radic Biol Med. 2014 Jun;71:390-401. doi: 10.1016/j.freeradbiomed.2014.03.003. Epub 2014 Mar 15.

PMID:
24637264
[PubMed - indexed for MEDLINE]
Free Article
10.

Demethyleneberberine, a natural mitochondria-targeted antioxidant, inhibits mitochondrial dysfunction, oxidative stress, and steatosis in alcoholic liver disease mouse model.

Zhang P, Qiang X, Zhang M, Ma D, Zhao Z, Zhou C, Liu X, Li R, Chen H, Zhang Y.

J Pharmacol Exp Ther. 2015 Jan;352(1):139-47. doi: 10.1124/jpet.114.219832. Epub 2014 Oct 31.

PMID:
25362106
[PubMed - indexed for MEDLINE]
11.

The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis.

Lowes DA, Thottakam BM, Webster NR, Murphy MP, Galley HF.

Free Radic Biol Med. 2008 Dec 1;45(11):1559-65. doi: 10.1016/j.freeradbiomed.2008.09.003. Epub 2008 Sep 17. Erratum in: Free Radic Biol Med. 2009 Oct 1;47(7):1098.

PMID:
18845241
[PubMed - indexed for MEDLINE]
12.

A mitochondrial-targeted coenzyme q analog prevents weight gain and ameliorates hepatic dysfunction in high-fat-fed mice.

Fink BD, Herlein JA, Guo DF, Kulkarni C, Weidemann BJ, Yu L, Grobe JL, Rahmouni K, Kerns RJ, Sivitz WI.

J Pharmacol Exp Ther. 2014 Dec;351(3):699-708. doi: 10.1124/jpet.114.219329. Epub 2014 Oct 9.

PMID:
25301169
[PubMed - indexed for MEDLINE]
13.

Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia-reperfusion: therapeutic potential of mitochondrially targeted antioxidants.

Mukhopadhyay P, Horváth B, Zsengellėr Z, Bátkai S, Cao Z, Kechrid M, Holovac E, Erdėlyi K, Tanchian G, Liaudet L, Stillman IE, Joseph J, Kalyanaraman B, Pacher P.

Free Radic Biol Med. 2012 Sep 1;53(5):1123-38. doi: 10.1016/j.freeradbiomed.2012.05.036. Epub 2012 Jun 6.

PMID:
22683818
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Is antioxidant potential of the mitochondrial targeted ubiquinone derivative MitoQ conserved in cells lacking mtDNA?

Lu C, Zhang D, Whiteman M, Armstrong JS.

Antioxid Redox Signal. 2008 Mar;10(3):651-60.

PMID:
17999633
[PubMed - indexed for MEDLINE]
15.

Pro-oxidant mitochondrial matrix-targeted ubiquinone MitoQ10 acts as anti-oxidant at retarded electron transport or proton pumping within Complex I.

Plecitá-Hlavatá L, Jezek J, Jezek P.

Int J Biochem Cell Biol. 2009 Aug-Sep;41(8-9):1697-707. doi: 10.1016/j.biocel.2009.02.015. Epub 2009 Mar 3.

PMID:
19433311
[PubMed - indexed for MEDLINE]
16.

Chronic ethanol consumption in mice alters hepatocyte lipid droplet properties.

Orlicky DJ, Roede JR, Bales E, Greenwood C, Greenberg A, Petersen D, McManaman JL.

Alcohol Clin Exp Res. 2011 Jun;35(6):1020-33. doi: 10.1111/j.1530-0277.2011.01434.x. Epub 2011 Apr 27.

PMID:
21535024
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Ethanol metabolism and oxidative stress are required for unfolded protein response activation and steatosis in zebrafish with alcoholic liver disease.

Tsedensodnom O, Vacaru AM, Howarth DL, Yin C, Sadler KC.

Dis Model Mech. 2013 Sep;6(5):1213-26. doi: 10.1242/dmm.012195. Epub 2013 Jun 20.

PMID:
23798569
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties.

Kelso GF, Porteous CM, Coulter CV, Hughes G, Porteous WK, Ledgerwood EC, Smith RA, Murphy MP.

J Biol Chem. 2001 Feb 16;276(7):4588-96. Epub 2000 Nov 22.

PMID:
11092892
[PubMed - indexed for MEDLINE]
Free Article
19.

Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis.

Shearn CT, Smathers RL, Jiang H, Orlicky DJ, Maclean KN, Petersen DR.

J Nutr Biochem. 2013 Aug;24(8):1436-45. doi: 10.1016/j.jnutbio.2012.12.002. Epub 2013 Mar 1.

PMID:
23465594
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Prolonged ethanol administration depletes mitochondrial DNA in MnSOD-overexpressing transgenic mice, but not in their wild type littermates.

Larosche I, Choumar A, Fromenty B, Lettéron P, Abbey-Toby A, Van Remmen H, Epstein CJ, Richardson A, Feldmann G, Pessayre D, Mansouri A.

Toxicol Appl Pharmacol. 2009 Feb 1;234(3):326-38. doi: 10.1016/j.taap.2008.11.004. Epub 2008 Nov 20.

PMID:
19063909
[PubMed - indexed for MEDLINE]
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