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AS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membrane.

Koumanov F, Richardson JD, Murrow BA, Holman GD.

J Biol Chem. 2011 May 13;286(19):16574-82. doi: 10.1074/jbc.M111.226092. Epub 2011 Mar 17.


The Rab GTPase-activating protein TBC1D4/AS160 contains an atypical phosphotyrosine-binding domain that interacts with plasma membrane phospholipids to facilitate GLUT4 trafficking in adipocytes.

Tan SX, Ng Y, Burchfield JG, Ramm G, Lambright DG, Stöckli J, James DE.

Mol Cell Biol. 2012 Dec;32(24):4946-59. doi: 10.1128/MCB.00761-12. Epub 2012 Oct 8.


Loss of AS160 Akt substrate causes Glut4 protein to accumulate in compartments that are primed for fusion in basal adipocytes.

Brewer PD, Romenskaia I, Kanow MA, Mastick CC.

J Biol Chem. 2011 Jul 29;286(30):26287-97. doi: 10.1074/jbc.M111.253880. Epub 2011 May 24.


Regulation of glucose transporter 4 translocation by the Rab guanosine triphosphatase-activating protein AS160/TBC1D4: role of phosphorylation and membrane association.

Stöckli J, Davey JR, Hohnen-Behrens C, Xu A, James DE, Ramm G.

Mol Endocrinol. 2008 Dec;22(12):2703-15. doi: 10.1210/me.2008-0111. Epub 2008 Sep 18.


Calmodulin binds to the Rab GTPase activating protein required for insulin-stimulated GLUT4 translocation.

Kane S, Lienhard GE.

Biochem Biophys Res Commun. 2005 Sep 16;335(1):175-80.


Identification of a novel AS160 splice variant that regulates GLUT4 translocation and glucose-uptake in rat muscle cells.

Baus D, Heermeier K, De Hoop M, Metz-Weidmann C, Gassenhuber J, Dittrich W, Welte S, Tennagels N.

Cell Signal. 2008 Dec;20(12):2237-46. doi: 10.1016/j.cellsig.2008.08.010. Epub 2008 Aug 17.


A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160.

Ramm G, Larance M, Guilhaus M, James DE.

J Biol Chem. 2006 Sep 29;281(39):29174-80. Epub 2006 Jul 31.


Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators.

Chen S, Murphy J, Toth R, Campbell DG, Morrice NA, Mackintosh C.

Biochem J. 2008 Jan 15;409(2):449-59.


The Rab GTPase-activating protein AS160 as a common regulator of insulin- and Galphaq-mediated intracellular GLUT4 vesicle distribution.

Yuasa T, Uchiyama K, Ogura Y, Kimura M, Teshigawara K, Hosaka T, Tanaka Y, Obata T, Sano H, Kishi K, Ebina Y.

Endocr J. 2009;56(3):345-59. Epub 2009 Jan 9.


AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain.

Mîinea CP, Sano H, Kane S, Sano E, Fukuda M, Peränen J, Lane WS, Lienhard GE.

Biochem J. 2005 Oct 1;391(Pt 1):87-93.


Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells.

Ishikura S, Bilan PJ, Klip A.

Biochem Biophys Res Commun. 2007 Feb 23;353(4):1074-9. Epub 2006 Dec 27.


The association of ClipR-59 protein with AS160 modulates AS160 protein phosphorylation and adipocyte Glut4 protein membrane translocation.

Ren W, Cheema S, Du K.

J Biol Chem. 2012 Aug 3;287(32):26890-900. doi: 10.1074/jbc.M112.357699. Epub 2012 Jun 11.


Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking.

Larance M, Ramm G, Stöckli J, van Dam EM, Winata S, Wasinger V, Simpson F, Graham M, Junutula JR, Guilhaus M, James DE.

J Biol Chem. 2005 Nov 11;280(45):37803-13. Epub 2005 Sep 8.


Interaction of the Akt substrate, AS160, with the glucose transporter 4 vesicle marker protein, insulin-regulated aminopeptidase.

Peck GR, Ye S, Pham V, Fernando RN, Macaulay SL, Chai SY, Albiston AL.

Mol Endocrinol. 2006 Oct;20(10):2576-83. Epub 2006 Jun 8.


GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells.

Randhawa VK, Ishikura S, Talior-Volodarsky I, Cheng AW, Patel N, Hartwig JH, Klip A.

J Biol Chem. 2008 Oct 3;283(40):27208-19. doi: 10.1074/jbc.M804282200. Epub 2008 Jul 23.


Inhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activation.

Chavez JA, Roach WG, Keller SR, Lane WS, Lienhard GE.

J Biol Chem. 2008 Apr 4;283(14):9187-95. doi: 10.1074/jbc.M708934200. Epub 2008 Feb 7.


Insulin-stimulated phosphorylation of the Rab GTPase-activating protein TBC1D1 regulates GLUT4 translocation.

Peck GR, Chavez JA, Roach WG, Budnik BA, Lane WS, Karlsson HK, Zierath JR, Lienhard GE.

J Biol Chem. 2009 Oct 30;284(44):30016-23. doi: 10.1074/jbc.M109.035568. Epub 2009 Sep 9.

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