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The human adenocarcinoma-associated gene, AGR2, induces expression of amphiregulin through Hippo pathway co-activator YAP1 activation.

Dong A, Gupta A, Pai RK, Tun M, Lowe AW.

J Biol Chem. 2011 May 20;286(20):18301-10. doi: 10.1074/jbc.M110.215707. Epub 2011 Mar 26.


Reconstitution of amphiregulin-epidermal growth factor receptor signaling in lung squamous cell carcinomas activates PTHrP gene expression and contributes to cancer-mediated diseases of the bone.

Gilmore JL, Gonterman RM, Menon K, Lorch G, Riese DJ 2nd, Robling A, Foley J.

Mol Cancer Res. 2009 Oct;7(10):1714-28. doi: 10.1158/1541-7786.MCR-09-0131. Epub 2009 Oct 13.


YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway.

Zhang J, Ji JY, Yu M, Overholtzer M, Smolen GA, Wang R, Brugge JS, Dyson NJ, Haber DA.

Nat Cell Biol. 2009 Dec;11(12):1444-50. doi: 10.1038/ncb1993. Epub 2009 Nov 22.


RASSF1A-mediated regulation of AREG via the Hippo pathway in hepatocellular carcinoma.

Ahn EY, Kim JS, Kim GJ, Park YN.

Mol Cancer Res. 2013 Jul;11(7):748-58. doi: 10.1158/1541-7786.MCR-12-0665. Epub 2013 Apr 17.


The adenocarcinoma-associated antigen, AGR2, promotes tumor growth, cell migration, and cellular transformation.

Wang Z, Hao Y, Lowe AW.

Cancer Res. 2008 Jan 15;68(2):492-7. doi: 10.1158/0008-5472.CAN-07-2930.


TAZ induces growth factor-independent proliferation through activation of EGFR ligand amphiregulin.

Yang N, Morrison CD, Liu P, Miecznikowski J, Bshara W, Han S, Zhu Q, Omilian AR, Li X, Zhang J.

Cell Cycle. 2012 Aug 1;11(15):2922-30. doi: 10.4161/cc.21386. Epub 2012 Aug 1.


Human antigen R-mediated mRNA stabilization is required for ultraviolet B-induced autoinduction of amphiregulin in keratinocytes.

Nakayama H, Fukuda S, Matsushita N, Nishida-Fukuda H, Inoue H, Shirakata Y, Hashimoto K, Higashiyama S.

J Biol Chem. 2013 Apr 12;288(15):10338-48. doi: 10.1074/jbc.M112.417527. Epub 2013 Feb 21.


Cross-suppression of EGFR ligands amphiregulin and epiregulin and de-repression of FGFR3 signalling contribute to cetuximab resistance in wild-type KRAS tumour cells.

Oliveras-Ferraros C, Cufí S, Queralt B, Vazquez-Martin A, Martin-Castillo B, de Llorens R, Bosch-Barrera J, Brunet J, Menendez JA.

Br J Cancer. 2012 Apr 10;106(8):1406-14. doi: 10.1038/bjc.2012.103.


AGR2 gene function requires a unique endoplasmic reticulum localization motif.

Gupta A, Dong A, Lowe AW.

J Biol Chem. 2012 Feb 10;287(7):4773-82. doi: 10.1074/jbc.M111.301531. Epub 2011 Dec 19.


Amphiregulin exosomes increase cancer cell invasion.

Higginbotham JN, Demory Beckler M, Gephart JD, Franklin JL, Bogatcheva G, Kremers GJ, Piston DW, Ayers GD, McConnell RE, Tyska MJ, Coffey RJ.

Curr Biol. 2011 May 10;21(9):779-86. doi: 10.1016/j.cub.2011.03.043. Epub 2011 Apr 21.


The role of amphiregulin in exemestane-resistant breast cancer cells: evidence of an autocrine loop.

Wang X, Masri S, Phung S, Chen S.

Cancer Res. 2008 Apr 1;68(7):2259-65. doi: 10.1158/0008-5472.CAN-07-5544.


Amphiregulin-EGFR signaling regulates PTHrP gene expression in breast cancer cells.

Gilmore JL, Scott JA, Bouizar Z, Robling A, Pitfield SE, Riese DJ 2nd, Foley J.

Breast Cancer Res Treat. 2008 Aug;110(3):493-505. Epub 2007 Sep 20.


Constitutive activation of epidermal growth factor receptor promotes tumorigenesis of Cr(VI)-transformed cells through decreased reactive oxygen species and apoptosis resistance development.

Kim D, Dai J, Fai LY, Yao H, Son YO, Wang L, Pratheeshkumar P, Kondo K, Shi X, Zhang Z.

J Biol Chem. 2015 Jan 23;290(4):2213-24. doi: 10.1074/jbc.M114.619783. Epub 2014 Dec 4.


Inhibition of epidermal growth factor receptor signalling reduces hypercalcaemia induced by human lung squamous-cell carcinoma in athymic mice.

Lorch G, Gilmore JL, Koltz PF, Gonterman RM, Laughner R, Lewis DA, Konger RL, Nadella KS, Toribio RE, Rosol TJ, Foley J.

Br J Cancer. 2007 Jul 16;97(2):183-93. Epub 2007 May 29.


Knock-down of amphiregulin inhibits cellular invasion in inflammatory breast cancer.

Baillo A, Giroux C, Ethier SP.

J Cell Physiol. 2011 Oct;226(10):2691-701. doi: 10.1002/jcp.22620.


Opposing activities of the Ras and Hippo pathways converge on regulation of YAP protein turnover.

Hong X, Nguyen HT, Chen Q, Zhang R, Hagman Z, Voorhoeve PM, Cohen SM.

EMBO J. 2014 Nov 3;33(21):2447-57. doi: 10.15252/embj.201489385. Epub 2014 Sep 1.


Differential expression of epidermal growth factor-related proteins in human colorectal tumors.

Ciardiello F, Kim N, Saeki T, Dono R, Persico MG, Plowman GD, Garrigues J, Radke S, Todaro GJ, Salomon DS.

Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7792-6.

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