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Three amino acid mutations (F51L, T59A, and S390L) in the capsid protein of the hepatitis E virus collectively contribute to virus attenuation.

Córdoba L, Huang YW, Opriessnig T, Harral KK, Beach NM, Finkielstein CV, Emerson SU, Meng XJ.

J Virol. 2011 Jun;85(11):5338-49. doi: 10.1128/JVI.02278-10. Epub 2011 Mar 30.


Deletions of the hypervariable region (HVR) in open reading frame 1 of hepatitis E virus do not abolish virus infectivity: evidence for attenuation of HVR deletion mutants in vivo.

Pudupakam RS, Huang YW, Opriessnig T, Halbur PG, Pierson FW, Meng XJ.

J Virol. 2009 Jan;83(1):384-95. doi: 10.1128/JVI.01854-08. Epub 2008 Oct 22.


Construction and characterization of infectious cDNA clones of a chicken strain of hepatitis E virus (HEV), avian HEV.

Huang FF, Pierson FW, Toth TE, Meng XJ.

J Gen Virol. 2005 Sep;86(Pt 9):2585-93.


Assessment of the cross-protective capability of recombinant capsid proteins derived from pig, rat, and avian hepatitis E viruses (HEV) against challenge with a genotype 3 HEV in pigs.

Sanford BJ, Opriessnig T, Kenney SP, Dryman BA, Córdoba L, Meng XJ.

Vaccine. 2012 Sep 28;30(44):6249-55. doi: 10.1016/j.vaccine.2012.08.013. Epub 2012 Aug 17.


Rescue of a genotype 4 human hepatitis E virus from cloned cDNA and characterization of intergenotypic chimeric viruses in cultured human liver cells and in pigs.

Córdoba L, Feagins AR, Opriessnig T, Cossaboom CM, Dryman BA, Huang YW, Meng XJ.

J Gen Virol. 2012 Oct;93(Pt 10):2183-94. doi: 10.1099/vir.0.043711-0. Epub 2012 Jul 25.


Cross-species infection of specific-pathogen-free pigs by a genotype 4 strain of human hepatitis E virus.

Feagins AR, Opriessnig T, Huang YW, Halbur PG, Meng XJ.

J Med Virol. 2008 Aug;80(8):1379-86. doi: 10.1002/jmv.21223.


Intergenotypic chimeric hepatitis E viruses (HEVs) with the genotype 4 human HEV capsid gene in the backbone of genotype 3 swine HEV are infectious in pigs.

Feagins AR, Córdoba L, Sanford BJ, Dryman BA, Huang YW, LeRoith T, Emerson SU, Meng XJ.

Virus Res. 2011 Mar;156(1-2):141-6. doi: 10.1016/j.virusres.2010.12.011. Epub 2010 Dec 30.


Infectivity of a genotype 4 hepatitis E virus cDNA clone by intrahepatic inoculation of laboratory rats.

Zhu Y, Yu X, Zhang Y, Ni Y, Si F, Yu R, Dong S, Huang Y, Li Z.

Vet Microbiol. 2013 Oct 25;166(3-4):405-11. doi: 10.1016/j.vetmic.2013.06.021. Epub 2013 Jul 9.


The course of hepatitis E virus infection in pigs after contact-infection and intravenous inoculation.

Bouwknegt M, Rutjes SA, Reusken CB, Stockhofe-Zurwieden N, Frankena K, de Jong MC, de Roda Husman AM, Poel WH.

BMC Vet Res. 2009 Feb 4;5:7. doi: 10.1186/1746-6148-5-7.


Long-term shedding of hepatitis E virus in the feces of pigs infected naturally, born to sows with and without maternal antibodies.

Kanai Y, Tsujikawa M, Yunoki M, Nishiyama S, Ikuta K, Hagiwara K.

J Med Virol. 2010 Jan;82(1):69-76. doi: 10.1002/jmv.21647.


Experimental infection of rabbits with rabbit and genotypes 1 and 4 hepatitis E viruses.

Ma H, Zheng L, Liu Y, Zhao C, Harrison TJ, Ma Y, Sun S, Zhang J, Wang Y.

PLoS One. 2010 Feb 11;5(2):e9160. doi: 10.1371/journal.pone.0009160.


Experimental infection of pigs with the newly identified swine hepatitis E virus (swine HEV), but not with human strains of HEV.

Meng XJ, Halbur PG, Haynes JS, Tsareva TS, Bruna JD, Royer RL, Purcell RH, Emerson SU.

Arch Virol. 1998;143(7):1405-15.


Experimental infection of Mongolian gerbils by a genotype 4 strain of swine hepatitis E virus.

Li W, Sun Q, She R, Wang D, Duan X, Yin J, Ding Y.

J Med Virol. 2009 Sep;81(9):1591-6. doi: 10.1002/jmv.21573.


Prior infection of pigs with a genotype 3 swine hepatitis E virus (HEV) protects against subsequent challenges with homologous and heterologous genotypes 3 and 4 human HEV.

Sanford BJ, Dryman BA, Huang YW, Feagins AR, Leroith T, Meng XJ.

Virus Res. 2011 Jul;159(1):17-22. doi: 10.1016/j.virusres.2011.04.010. Epub 2011 Apr 22.


Systematic pathogenesis and replication of avian hepatitis E virus in specific-pathogen-free adult chickens.

Billam P, Huang FF, Sun ZF, Pierson FW, Duncan RB, Elvinger F, Guenette DK, Toth TE, Meng XJ.

J Virol. 2005 Mar;79(6):3429-37. Erratum in: J Virol. 2006 Jul;80(13):6721.


Swine hepatitis E virus in rural southern China: genetic characterization and experimental infection in rhesus monkeys (Macaca mulatta).

Ji Y, Zhu Y, Liang J, Wei X, Yang X, Wang L, Li L, Chang Y, Tang R, Zhuang H.

J Gastroenterol. 2008;43(7):565-70. doi: 10.1007/s00535-008-2196-3. Epub 2008 Jul 23.


Use of a swine bioassay and a RT-PCR assay to assess the risk of transmission of swine hepatitis E virus in pigs.

Kasorndorkbua C, Halbur PG, Thomas PJ, Guenette DK, Toth TE, Meng XJ.

J Virol Methods. 2002 Mar;101(1-2):71-8.


Comparative pathogenesis of infection of pigs with hepatitis E viruses recovered from a pig and a human.

Halbur PG, Kasorndorkbua C, Gilbert C, Guenette D, Potters MB, Purcell RH, Emerson SU, Toth TE, Meng XJ.

J Clin Microbiol. 2001 Mar;39(3):918-23.


Prevalence of four different subgenotypes of genotype 4 hepatitis E virus among swine in the Shanghai area of China.

Yan Y, Zhang W, Shen Q, Cui L, Hua X.

Acta Vet Scand. 2008 May 31;50:12. doi: 10.1186/1751-0147-50-12.

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