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Results: 1 to 20 of 102

1.

Novel small molecule, XZH-5, inhibits constitutive and interleukin-6-induced STAT3 phosphorylation in human rhabdomyosarcoma cells.

Liu A, Liu Y, Xu Z, Yu W, Wang H, Li C, Lin J.

Cancer Sci. 2011 Jul;102(7):1381-7. doi: 10.1111/j.1349-7006.2011.01932.x. Epub 2011 May 5.

PMID:
21435102
[PubMed - indexed for MEDLINE]
2.

XZH-5 inhibits STAT3 phosphorylation and enhances the cytotoxicity of chemotherapeutic drugs in human breast and pancreatic cancer cells.

Liu A, Liu Y, Jin Z, Hu Q, Lin L, Jou D, Yang J, Xu Z, Wang H, Li C, Lin J.

PLoS One. 2012;7(10):e46624. doi: 10.1371/journal.pone.0046624. Epub 2012 Oct 3.

PMID:
23056374
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

XZH-5 inhibits STAT3 phosphorylation and causes apoptosis in human hepatocellular carcinoma cells.

Liu Y, Liu A, Xu Z, Yu W, Wang H, Li C, Lin J.

Apoptosis. 2011 May;16(5):502-10. doi: 10.1007/s10495-011-0578-0.

PMID:
21311975
[PubMed - indexed for MEDLINE]
4.

Two small molecule compounds, LLL12 and FLLL32, exhibit potent inhibitory activity on STAT3 in human rhabdomyosarcoma cells.

Wei CC, Ball S, Lin L, Liu A, Fuchs JR, Li PK, Li C, Lin J.

Int J Oncol. 2011 Jan;38(1):279-85.

PMID:
21109950
[PubMed - indexed for MEDLINE]
5.

Celecoxib inhibits STAT3 phosphorylation and suppresses cell migration and colony forming ability in rhabdomyosarcoma cells.

Reed S, Li H, Li C, Lin J.

Biochem Biophys Res Commun. 2011 Apr 15;407(3):450-5. doi: 10.1016/j.bbrc.2011.03.014. Epub 2011 Mar 21.

PMID:
21397587
[PubMed - indexed for MEDLINE]
6.

8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a novel janus kinase 2 inhibitor, increases chemotherapy sensitivity in human ovarian cancer cells.

Duan Z, Bradner J, Greenberg E, Mazitschek R, Foster R, Mahoney J, Seiden MV.

Mol Pharmacol. 2007 Nov;72(5):1137-45. Epub 2007 Aug 3.

PMID:
17675586
[PubMed - indexed for MEDLINE]
Free Article
7.

A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.

Lin L, Hutzen B, Li PK, Ball S, Zuo M, DeAngelis S, Foust E, Sobo M, Friedman L, Bhasin D, Cen L, Li C, Lin J.

Neoplasia. 2010 Jan;12(1):39-50.

PMID:
20072652
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells.

Bharti AC, Donato N, Aggarwal BB.

J Immunol. 2003 Oct 1;171(7):3863-71.

PMID:
14500688
[PubMed - indexed for MEDLINE]
Free Article
9.

SD-1029 inhibits signal transducer and activator of transcription 3 nuclear translocation.

Duan Z, Bradner JE, Greenberg E, Levine R, Foster R, Mahoney J, Seiden MV.

Clin Cancer Res. 2006 Nov 15;12(22):6844-52.

PMID:
17121906
[PubMed - indexed for MEDLINE]
Free Article
10.

Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells.

Shin DS, Kim HN, Shin KD, Yoon YJ, Kim SJ, Han DC, Kwon BM.

Cancer Res. 2009 Jan 1;69(1):193-202. doi: 10.1158/0008-5472.CAN-08-2575.

PMID:
19118003
[PubMed - indexed for MEDLINE]
Free Article
11.

Interferon-gamma-induced dephosphorylation of STAT3 and apoptosis are dependent on the mTOR pathway.

Fang P, Hwa V, Rosenfeld RG.

Exp Cell Res. 2006 May 1;312(8):1229-39. Epub 2006 Jan 19.

PMID:
16427044
[PubMed - indexed for MEDLINE]
12.

Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation.

Bhutani M, Pathak AK, Nair AS, Kunnumakkara AB, Guha S, Sethi G, Aggarwal BB.

Clin Cancer Res. 2007 May 15;13(10):3024-32.

PMID:
17505005
[PubMed - indexed for MEDLINE]
Free Article
13.

Aspirin induces apoptosis through the blockade of IL-6-STAT3 signaling pathway in human glioblastoma A172 cells.

Kim SR, Bae MK, Kim JY, Wee HJ, Yoo MA, Bae SK.

Biochem Biophys Res Commun. 2009 Sep 18;387(2):342-7. doi: 10.1016/j.bbrc.2009.07.022. Epub 2009 Jul 10.

PMID:
19595669
[PubMed - indexed for MEDLINE]
14.

IL-6, a risk factor for hepatocellular carcinoma: FLLL32 inhibits IL-6-induced STAT3 phosphorylation in human hepatocellular cancer cells.

Liu Y, Fuchs J, Li C, Lin J.

Cell Cycle. 2010 Sep 1;9(17):3423-7. Epub 2010 Sep 8.

PMID:
20818158
[PubMed - indexed for MEDLINE]
Free Article
15.

Chemical probes that competitively and selectively inhibit Stat3 activation.

Xu X, Kasembeli MM, Jiang X, Tweardy BJ, Tweardy DJ.

PLoS One. 2009;4(3):e4783. doi: 10.1371/journal.pone.0004783. Epub 2009 Mar 10.

PMID:
19274102
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells.

Lin L, Deangelis S, Foust E, Fuchs J, Li C, Li PK, Schwartz EB, Lesinski GB, Benson D, Lü J, Hoyt D, Lin J.

Mol Cancer. 2010 Aug 16;9:217. doi: 10.1186/1476-4598-9-217.

PMID:
20712901
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

A small-molecule compound identified through a cell-based screening inhibits JAK/STAT pathway signaling in human cancer cells.

Kim BH, Yin CH, Guo Q, Bach EA, Lee H, Sandoval C, Jayabose S, Ulaczyk-Lesanko A, Hall DG, Baeg GH.

Mol Cancer Ther. 2008 Sep;7(9):2672-80. doi: 10.1158/1535-7163.MCT-08-0309.

PMID:
18790749
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Withaferin A inhibits JAK/STAT3 signaling and induces apoptosis of human renal carcinoma Caki cells.

Um HJ, Min KJ, Kim DE, Kwon TK.

Biochem Biophys Res Commun. 2012 Oct 12;427(1):24-9. doi: 10.1016/j.bbrc.2012.08.133. Epub 2012 Sep 12.

PMID:
22982675
[PubMed - indexed for MEDLINE]
19.

A Novel Small Molecular STAT3 Inhibitor, LY5 Inhibits Cell Viability, Cell Migration, And Angiogenesis in Medulloblastoma Cells.

Xiao H, Bid HK, Jou D, Wu X, Yu W, Li C, Houghton PJ, Lin J.

J Biol Chem. 2014 Oct 13. pii: jbc.M114.616748. [Epub ahead of print]

PMID:
25313399
[PubMed - as supplied by publisher]
Free Article
20.

Antitumor activity of a novel small molecule STAT3 inhibitor against a human lymphoma cell line with high STAT3 activation.

Ashizawa T, Miyata H, Ishii H, Oshita C, Matsuno K, Masuda Y, Furuya T, Okawara T, Otsuka M, Ogo N, Asai A, Akiyama Y.

Int J Oncol. 2011 May;38(5):1245-52. doi: 10.3892/ijo.2011.957. Epub 2011 Feb 28.

PMID:
21369699
[PubMed - indexed for MEDLINE]

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