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Results: 1 to 20 of 99

1.

Cardiac myosin activation: a potential therapeutic approach for systolic heart failure.

Malik FI, Hartman JJ, Elias KA, Morgan BP, Rodriguez H, Brejc K, Anderson RL, Sueoka SH, Lee KH, Finer JT, Sakowicz R, Baliga R, Cox DR, Garard M, Godinez G, Kawas R, Kraynack E, Lenzi D, Lu PP, Muci A, Niu C, Qian X, Pierce DW, Pokrovskii M, Suehiro I, Sylvester S, Tochimoto T, Valdez C, Wang W, Katori T, Kass DA, Shen YT, Vatner SF, Morgans DJ.

Science. 2011 Mar 18;331(6023):1439-43. doi: 10.1126/science.1200113.

PMID:
21415352
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Improvement of cardiac function by a cardiac Myosin activator in conscious dogs with systolic heart failure.

Shen YT, Malik FI, Zhao X, Depre C, Dhar SK, Abarzúa P, Morgans DJ, Vatner SF.

Circ Heart Fail. 2010 Jul;3(4):522-7. doi: 10.1161/CIRCHEARTFAILURE.109.930321. Epub 2010 May 24.

PMID:
20498236
[PubMed - indexed for MEDLINE]
Free Article
3.

Medicine. Chemically tuned myosin motors.

Leinwand LA, Moss RL.

Science. 2011 Mar 18;331(6023):1392-3. doi: 10.1126/science.1204207. No abstract available.

PMID:
21415340
[PubMed - indexed for MEDLINE]
4.

Cardiac myosin activation part 1: from concept to clinic.

Malik FI, Morgan BP.

J Mol Cell Cardiol. 2011 Oct;51(4):454-61. doi: 10.1016/j.yjmcc.2011.05.006. Epub 2011 May 17. Review.

PMID:
21616079
[PubMed - indexed for MEDLINE]
5.

The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial.

Cleland JG, Teerlink JR, Senior R, Nifontov EM, Mc Murray JJ, Lang CC, Tsyrlin VA, Greenberg BH, Mayet J, Francis DP, Shaburishvili T, Monaghan M, Saltzberg M, Neyses L, Wasserman SM, Lee JH, Saikali KG, Clarke CP, Goldman JH, Wolff AA, Malik FI.

Lancet. 2011 Aug 20;378(9792):676-83. doi: 10.1016/S0140-6736(11)61126-4.

PMID:
21856481
[PubMed - indexed for MEDLINE]
6.

Dose-dependent augmentation of cardiac systolic function with the selective cardiac myosin activator, omecamtiv mecarbil: a first-in-man study.

Teerlink JR, Clarke CP, Saikali KG, Lee JH, Chen MM, Escandon RD, Elliott L, Bee R, Habibzadeh MR, Goldman JH, Schiller NB, Malik FI, Wolff AA.

Lancet. 2011 Aug 20;378(9792):667-75. doi: 10.1016/S0140-6736(11)61219-1.

PMID:
21856480
[PubMed - indexed for MEDLINE]
7.

A new approach to inotropic therapy in the treatment of heart failure: cardiac myosin activators in treatment of HF.

Garg V, Frishman WH.

Cardiol Rev. 2013 May-Jun;21(3):155-9. doi: 10.1097/CRD.0b013e318275889c. Review.

PMID:
23018669
[PubMed - indexed for MEDLINE]
8.

A novel approach to improve cardiac performance: cardiac myosin activators.

Teerlink JR.

Heart Fail Rev. 2009 Dec;14(4):289-98. doi: 10.1007/s10741-009-9135-0. Review.

PMID:
19234787
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

In vivo and in vitro cardiac responses to beta-adrenergic stimulation in volume-overload heart failure.

Guggilam A, Hutchinson KR, West TA, Kelly AP, Galantowicz ML, Davidoff AJ, Sadayappan S, Lucchesi PA.

J Mol Cell Cardiol. 2013 Apr;57:47-58. doi: 10.1016/j.yjmcc.2012.11.013. Epub 2012 Dec 7.

PMID:
23220155
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Cardiac myosin activation: will theory and practice coincide?

Dickstein K.

Lancet. 2011 Aug 20;378(9792):639-41. doi: 10.1016/S0140-6736(11)61298-1. No abstract available.

PMID:
21856465
[PubMed - indexed for MEDLINE]
11.

Human essential myosin light chain isoforms revealed distinct myosin binding, sarcomeric sorting, and inotropic activity.

Petzhold D, Lossie J, Keller S, Werner S, Haase H, Morano I.

Cardiovasc Res. 2011 Jun 1;90(3):513-20. doi: 10.1093/cvr/cvr026. Epub 2011 Jan 24.

PMID:
21262909
[PubMed - indexed for MEDLINE]
Free Article
12.

Halothane and isoflurane do not directly interact with cardiac cross-bridge function.

Vivien B, Lecarpentier Y, Riou B, Coirault C.

Anesthesiology. 2005 Feb;102(2):364-70.

PMID:
15681952
[PubMed - indexed for MEDLINE]
13.

Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation.

Hussain RI, Qvigstad E, Birkeland JA, Eikemo H, Glende A, Sjaastad I, Skomedal T, Osnes JB, Levy FO, Krobert KA.

Br J Pharmacol. 2009 Feb;156(4):575-86. doi: 10.1111/j.1750-3639.2009.00016.x. Epub 2009 Jan 21.

PMID:
19159405
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Inotropic response of cardiac ventricular myocytes to beta-adrenergic stimulation with isoproterenol exhibits diurnal variation: involvement of nitric oxide.

Collins HE, Rodrigo GC.

Circ Res. 2010 Apr 16;106(7):1244-52. doi: 10.1161/CIRCRESAHA.109.213942. Epub 2010 Feb 18.

PMID:
20167926
[PubMed - indexed for MEDLINE]
Free Article
15.

Cardiac myosin isoforms from different species have unique enzymatic and mechanical properties.

Malmqvist UP, Aronshtam A, Lowey S.

Biochemistry. 2004 Nov 30;43(47):15058-65.

PMID:
15554713
[PubMed - indexed for MEDLINE]
16.

Adrenergic regulation of myosin adenosine triphosphatase activity.

Winegrad S, Weisberg A, Lin LE, McClellan G.

Circ Res. 1986 Jan;58(1):83-95.

PMID:
3002659
[PubMed - indexed for MEDLINE]
Free Article
17.

Omecamtiv mecarbil: a promising new drug in systolic heart failure.

Meijs MF, Asselbergs FW, Doevendans PA.

Eur J Heart Fail. 2012 Mar;14(3):232-3. doi: 10.1093/eurjhf/hfr178. Epub 2011 Dec 28. No abstract available.

PMID:
22210833
[PubMed - indexed for MEDLINE]
18.

[Interrelation between cardiac pump function disturbances and cardiac contractility after beta-adrenergic hyperstimulation of the heart in rats].

Kuz'menko MO, Pavliuchenko VB, Tumanovs'ka LV, Dosenko VIe, Moĭbenko OO.

Fiziol Zh. 2011;57(2):3-13. Ukrainian.

PMID:
21848219
[PubMed - indexed for MEDLINE]
19.

Molecular mechanics of mouse cardiac myosin isoforms.

Alpert NR, Brosseau C, Federico A, Krenz M, Robbins J, Warshaw DM.

Am J Physiol Heart Circ Physiol. 2002 Oct;283(4):H1446-54. Erratum in: Am J Physiol Heart Circ Physiol 2002 Dec;283(6):following table of contents.

PMID:
12234796
[PubMed - indexed for MEDLINE]
Free Article
20.

Neuregulins regulate cardiac parasympathetic activity: muscarinic modulation of beta-adrenergic activity in myocytes from mice with neuregulin-1 gene deletion.

Okoshi K, Nakayama M, Yan X, Okoshi MP, Schuldt AJ, Marchionni MA, Lorell BH.

Circulation. 2004 Aug 10;110(6):713-7. Epub 2004 Aug 2.

PMID:
15289373
[PubMed - indexed for MEDLINE]
Free Article
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