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Results: 1 to 20 of 106

1.

Role of metalation in the topoisomerase IIα inhibition and antiproliferation activity of a series of α-heterocyclic-N4-substituted thiosemicarbazones and their Cu(II) complexes.

Zeglis BM, Divilov V, Lewis JS.

J Med Chem. 2011 Apr 14;54(7):2391-8. doi: 10.1021/jm101532u. Epub 2011 Mar 10.

PMID:
21391686
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Copper(II) complexes with highly water-soluble L- and D-proline-thiosemicarbazone conjugates as potential inhibitors of Topoisomerase IIα.

Bacher F, Enyedy É, Nagy NV, Rockenbauer A, Bognár GM, Trondl R, Novak MS, Klapproth E, Kiss T, Arion VB.

Inorg Chem. 2013 Aug 5;52(15):8895-908. doi: 10.1021/ic401079w. Epub 2013 Jul 5.

PMID:
23829568
[PubMed - indexed for MEDLINE]
3.

A series of alpha-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIalpha catalytic activity.

Huang H, Chen Q, Ku X, Meng L, Lin L, Wang X, Zhu C, Wang Y, Chen Z, Li M, Jiang H, Chen K, Ding J, Liu H.

J Med Chem. 2010 Apr 22;53(8):3048-64. doi: 10.1021/jm9014394.

PMID:
20353152
[PubMed - indexed for MEDLINE]
4.

Synthesis and structure of [(η(6)-p-cymene)Ru(2-anthracen-9-ylmethylene-N-ethylhydrazinecarbothioamide)Cl]Cl; biological evaluation, topoisomerase II inhibition and reaction with DNA and human serum albumin.

Beckford F, Thessing J, Woods J, Didion J, Gerasimchuk N, Gonzalez-Sarrias A, Seeram NP.

Metallomics. 2011 May 1;3(5):491-502. doi: 10.1039/c1mt00003a. Epub 2011 Feb 23.

PMID:
21347491
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

3-(3-Butylamino-2-hydroxy-propoxy)-1-hydroxy-xanthen-9-one acts as a topoisomerase IIα catalytic inhibitor with low DNA damage.

Park SE, Chang IH, Jun KY, Lee E, Lee ES, Na Y, Kwon Y.

Eur J Med Chem. 2013 Nov;69:139-45. doi: 10.1016/j.ejmech.2013.07.048. Epub 2013 Aug 11.

PMID:
24013413
[PubMed - indexed for MEDLINE]
6.

The anticancer thiosemicarbazones Dp44mT and triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα.

Yalowich JC, Wu X, Zhang R, Kanagasabai R, Hornbaker M, Hasinoff BB.

Biochem Pharmacol. 2012 Jul 1;84(1):52-8. doi: 10.1016/j.bcp.2012.03.021. Epub 2012 Apr 4.

PMID:
22503743
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

L- and D-proline thiosemicarbazone conjugates: coordination behavior in solution and the effect of copper(II) coordination on their antiproliferative activity.

Milunovic MN, Enyedy É, Nagy NV, Kiss T, Trondl R, Jakupec MA, Keppler BK, Krachler R, Novitchi G, Arion VB.

Inorg Chem. 2012 Sep 3;51(17):9309-21. doi: 10.1021/ic300967j. Epub 2012 Aug 13.

PMID:
22889304
[PubMed - indexed for MEDLINE]
8.

Cytotoxic activity, albumin and DNA binding of new copper(II) complexes with chalcone-derived thiosemicarbazones.

Da Silva JG, Recio Despaigne AA, Louro SR, Bandeira CC, Souza-Fagundes EM, Beraldo H.

Eur J Med Chem. 2013 Jul;65:415-26. doi: 10.1016/j.ejmech.2013.04.036. Epub 2013 May 16.

PMID:
23747809
[PubMed - indexed for MEDLINE]
9.

Synthesis, biological evaluation, and molecular docking study of 3-(3'-heteroatom substituted-2'-hydroxy-1'-propyloxy) xanthone analogues as novel topoisomerase IIα catalytic inhibitor.

Jun KY, Lee EY, Jung MJ, Lee OH, Lee ES, Park Choo HY, Na Y, Kwon Y.

Eur J Med Chem. 2011 Jun;46(6):1964-71. doi: 10.1016/j.ejmech.2011.01.011. Epub 2011 Jan 15.

PMID:
21419530
[PubMed - indexed for MEDLINE]
10.

Chiral ruthenium(II) anthraquinone complexes as dual inhibitors of topoisomerases I and II.

Kou JF, Qian C, Wang JQ, Chen X, Wang LL, Chao H, Ji LN.

J Biol Inorg Chem. 2012 Jan;17(1):81-96. doi: 10.1007/s00775-011-0831-6. Epub 2011 Aug 21.

PMID:
21858685
[PubMed - indexed for MEDLINE]
11.

N-fused imidazoles as novel anticancer agents that inhibit catalytic activity of topoisomerase IIα and induce apoptosis in G1/S phase.

Baviskar AT, Madaan C, Preet R, Mohapatra P, Jain V, Agarwal A, Guchhait SK, Kundu CN, Banerjee UC, Bharatam PV.

J Med Chem. 2011 Jul 28;54(14):5013-30. doi: 10.1021/jm200235u. Epub 2011 Jun 23.

PMID:
21644529
[PubMed - indexed for MEDLINE]
12.

Synthesis of friedelan triterpenoid analogs with DNA topoisomerase IIα inhibitory activity and their molecular docking studies.

Mandal A, Ghosh S, Bothra AK, Nanda AK, Ghosh P.

Eur J Med Chem. 2012 Aug;54:137-43. doi: 10.1016/j.ejmech.2012.04.037. Epub 2012 May 8.

PMID:
22633831
[PubMed - indexed for MEDLINE]
13.

Role of substitution at terminal nitrogen of 2-oxo-1,2-dihydroquinoline-3-carbaldehyde thiosemicarbazones on the coordination behavior and structure and biological properties of their palladium(II) complexes.

Ramachandran E, Senthil Raja D, Rath NP, Natarajan K.

Inorg Chem. 2013 Feb 4;52(3):1504-14. doi: 10.1021/ic302258k. Epub 2013 Jan 16.

PMID:
23323516
[PubMed - indexed for MEDLINE]
14.

Further SAR studies on bicyclic basic merbarone analogues as potent antiproliferative agents.

Spallarossa A, Rotolo C, Sissi C, Marson G, Greco ML, Ranise A, La Colla P, Busonera B, Loddo R.

Bioorg Med Chem. 2013 Nov 1;21(21):6328-36. doi: 10.1016/j.bmc.2013.08.056. Epub 2013 Sep 6.

PMID:
24063907
[PubMed - indexed for MEDLINE]
15.

Loss of O⁶-methylguanine-DNA methyltransferase confers collateral sensitivity to carmustine in topoisomerase II-mediated doxorubicin resistant triple negative breast cancer cells.

Raguz S, Adams C, Masrour N, Rasul S, Papoutsoglou P, Hu Y, Cazzanelli G, Zhou Y, Patel N, Coombes C, Yagüe E.

Biochem Pharmacol. 2013 Jan 15;85(2):186-96. doi: 10.1016/j.bcp.2012.10.020. Epub 2012 Oct 30.

PMID:
23122841
[PubMed - indexed for MEDLINE]
16.

Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.

Thapa U, Thapa P, Karki R, Yun M, Choi JH, Jahng Y, Lee E, Jeon KH, Na Y, Ha EM, Cho WJ, Kwon Y, Lee ES.

Eur J Med Chem. 2011 Aug;46(8):3201-9. doi: 10.1016/j.ejmech.2011.04.029. Epub 2011 Apr 29.

PMID:
21601964
[PubMed - indexed for MEDLINE]
17.

Synthesis, cytotoxicity and topoisomerase II inhibitory activity of lomefloxacin derivatives.

Zhou Y, Xu X, Sun Y, Wang H, Sun H, You Q.

Bioorg Med Chem Lett. 2013 May 15;23(10):2974-8. doi: 10.1016/j.bmcl.2013.03.037. Epub 2013 Mar 20.

PMID:
23566520
[PubMed - indexed for MEDLINE]
18.

Copper(II) complexes with substituted thiosemicarbazones of thiophene-2-carboxaldehyde: synthesis, characterization and antiamoebic activity against E. histolytica.

Sharma S, Athar F, Maurya MR, Azam A.

Eur J Med Chem. 2005 Dec;40(12):1414-9. Epub 2005 Aug 29.

PMID:
16129515
[PubMed - indexed for MEDLINE]
19.

Mn(II), Co(II) and Zn(II) complexes with heterocyclic substituted thiosemicarbazones: synthesis, characterization, X-ray crystal structures and antitumor comparison.

Li MX, Chen CL, Zhang D, Niu JY, Ji BS.

Eur J Med Chem. 2010 Jul;45(7):3169-77. doi: 10.1016/j.ejmech.2010.04.009. Epub 2010 Apr 14.

PMID:
20434816
[PubMed - indexed for MEDLINE]
20.

Synthesis and biological evaluation of benzo[a]phenazine derivatives as a dual inhibitor of topoisomerase I and II.

Zhuo ST, Li CY, Hu MH, Chen SB, Yao PF, Huang SL, Ou TM, Tan JH, An LK, Li D, Gu LQ, Huang ZS.

Org Biomol Chem. 2013 Jun 28;11(24):3989-4005. doi: 10.1039/c3ob40325d.

PMID:
23657605
[PubMed - indexed for MEDLINE]

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