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Results: 1 to 20 of 97

1.

Direct activation of Epac by sulfonylurea is isoform selective.

Herbst KJ, Coltharp C, Amzel LM, Zhang J.

Chem Biol. 2011 Feb 25;18(2):243-51. doi: 10.1016/j.chembiol.2010.12.007.

PMID:
21338921
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Exchange protein directly activated by cyclic AMP isoform 2 is not a direct target of sulfonylurea drugs.

Tsalkova T, Gribenko AV, Cheng X.

Assay Drug Dev Technol. 2011 Feb;9(1):88-91. doi: 10.1089/adt.2010.0338. Epub 2010 Dec 6.

PMID:
21133673
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs.

Zhang CL, Katoh M, Shibasaki T, Minami K, Sunaga Y, Takahashi H, Yokoi N, Iwasaki M, Miki T, Seino S.

Science. 2009 Jul 31;325(5940):607-10. doi: 10.1126/science.1172256.

PMID:
19644119
[PubMed - indexed for MEDLINE]
Free Article
4.

Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation.

Wang Z, Dillon TJ, Pokala V, Mishra S, Labudda K, Hunter B, Stork PJ.

Mol Cell Biol. 2006 Mar;26(6):2130-45.

PMID:
16507992
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Isoform-specific antagonists of exchange proteins directly activated by cAMP.

Tsalkova T, Mei FC, Li S, Chepurny OG, Leech CA, Liu T, Holz GG, Woods VL Jr, Cheng X.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18613-8. doi: 10.1073/pnas.1210209109. Epub 2012 Oct 22.

PMID:
23091014
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.

de Rooij J, Rehmann H, van Triest M, Cool RH, Wittinghofer A, Bos JL.

J Biol Chem. 2000 Jul 7;275(27):20829-36.

PMID:
10777494
[PubMed - indexed for MEDLINE]
Free Article
7.

Antidiabetic sulfonylureas and cAMP cooperatively activate Epac2A.

Takahashi T, Shibasaki T, Takahashi H, Sugawara K, Ono A, Inoue N, Furuya T, Seino S.

Sci Signal. 2013 Oct 22;6(298):ra94. doi: 10.1126/scisignal.2004581.

PMID:
24150255
[PubMed - indexed for MEDLINE]
8.

cAMP-Epac2-mediated activation of Rap1 in developing male germ cells: RA-RhoGAP as a possible direct down-stream effector.

Aivatiadou E, Ripolone M, Brunetti F, Berruti G.

Mol Reprod Dev. 2009 Apr;76(4):407-16. doi: 10.1002/mrd.20963.

PMID:
18937323
[PubMed - indexed for MEDLINE]
9.

Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM.

Chepurny OG, Leech CA, Kelley GG, Dzhura I, Dzhura E, Li X, Rindler MJ, Schwede F, Genieser HG, Holz GG.

J Biol Chem. 2009 Apr 17;284(16):10728-36. doi: 10.1074/jbc.M900166200. Epub 2009 Feb 25.

PMID:
19244230
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Treating diabetes today: a matter of selectivity of sulphonylureas.

Seino S, Takahashi H, Takahashi T, Shibasaki T.

Diabetes Obes Metab. 2012 Jan;14 Suppl 1:9-13. doi: 10.1111/j.1463-1326.2011.01507.x. Review.

PMID:
22118705
[PubMed - indexed for MEDLINE]
11.

Ras is required for the cyclic AMP-dependent activation of Rap1 via Epac2.

Liu C, Takahashi M, Li Y, Song S, Dillon TJ, Shinde U, Stork PJ.

Mol Cell Biol. 2008 Dec;28(23):7109-25. doi: 10.1128/MCB.01060-08. Epub 2008 Sep 29.

PMID:
18824540
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1).

Courilleau D, Bouyssou P, Fischmeister R, Lezoualc'h F, Blondeau JP.

Biochem Biophys Res Commun. 2013 Oct 25;440(3):443-8. doi: 10.1016/j.bbrc.2013.09.107. Epub 2013 Oct 4.

PMID:
24099776
[PubMed - indexed for MEDLINE]
13.

Understanding cAMP-dependent allostery by NMR spectroscopy: comparative analysis of the EPAC1 cAMP-binding domain in its apo and cAMP-bound states.

Mazhab-Jafari MT, Das R, Fotheringham SA, SilDas S, Chowdhury S, Melacini G.

J Am Chem Soc. 2007 Nov 21;129(46):14482-92. Epub 2007 Oct 31.

PMID:
17973384
[PubMed - indexed for MEDLINE]
14.

Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans.

Dzhura I, Chepurny OG, Leech CA, Roe MW, Dzhura E, Xu X, Lu Y, Schwede F, Genieser HG, Smrcka AV, Holz GG.

Islets. 2011 May-Jun;3(3):121-8. Epub 2011 May 1.

PMID:
21478675
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane.

Li Y, Asuri S, Rebhun JF, Castro AF, Paranavitana NC, Quilliam LA.

J Biol Chem. 2006 Feb 3;281(5):2506-14. Epub 2005 Nov 29.

PMID:
16316996
[PubMed - indexed for MEDLINE]
Free Article
16.

cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension.

Christensen AE, Selheim F, de Rooij J, Dremier S, Schwede F, Dao KK, Martinez A, Maenhaut C, Bos JL, Genieser HG, Døskeland SO.

J Biol Chem. 2003 Sep 12;278(37):35394-402. Epub 2003 Jun 20.

PMID:
12819211
[PubMed - indexed for MEDLINE]
Free Article
17.

Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B.

Rehmann H, Arias-Palomo E, Hadders MA, Schwede F, Llorca O, Bos JL.

Nature. 2008 Sep 4;455(7209):124-7. doi: 10.1038/nature07187. Epub 2008 Jul 27.

PMID:
18660803
[PubMed - indexed for MEDLINE]
18.

Facilitation of ß-cell K(ATP) channel sulfonylurea sensitivity by a cAMP analog selective for the cAMP-regulated guanine nucleotide exchange factor Epac.

Leech CA, Dzhura I, Chepurny OG, Schwede F, Genieser HG, Holz GG.

Islets. 2010 Mar-Apr;2(2):72-81.

PMID:
20428467
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Epac2: a sulfonylurea receptor?

Rehmann H.

Biochem Soc Trans. 2012 Feb;40(1):6-10. doi: 10.1042/BST20110640.

PMID:
22260657
[PubMed - indexed for MEDLINE]
20.

Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state.

Rehmann H, Das J, Knipscheer P, Wittinghofer A, Bos JL.

Nature. 2006 Feb 2;439(7076):625-8.

PMID:
16452984
[PubMed - indexed for MEDLINE]

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