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Osteopontin undergoes polymerization in vivo and gains chemotactic activity for neutrophils mediated by integrin alpha9beta1.

Nishimichi N, Hayashita-Kinoh H, Chen C, Matsuda H, Sheppard D, Yokosaki Y.

J Biol Chem. 2011 Apr 1;286(13):11170-8. doi: 10.1074/jbc.M110.189258. Epub 2011 Feb 14.


Polymeric osteopontin employs integrin alpha9beta1 as a receptor and attracts neutrophils by presenting a de novo binding site.

Nishimichi N, Higashikawa F, Kinoh HH, Tateishi Y, Matsuda H, Yokosaki Y.

J Biol Chem. 2009 May 29;284(22):14769-76. doi: 10.1074/jbc.M901515200. Epub 2009 Apr 3.


Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with alpha9beta1 and alpha4beta1 integrins.

Grassinger J, Haylock DN, Storan MJ, Haines GO, Williams B, Whitty GA, Vinson AR, Be CL, Li S, Sørensen ES, Tam PP, Denhardt DT, Sheppard D, Choong PF, Nilsson SK.

Blood. 2009 Jul 2;114(1):49-59. doi: 10.1182/blood-2009-01-197988. Epub 2009 May 5.


Thrombin cleavage of osteopontin disrupts a pro-chemotactic sequence for dendritic cells, which is compensated by the release of its pro-chemotactic C-terminal fragment.

Shao Z, Morser J, Leung LL.

J Biol Chem. 2014 Sep 26;289(39):27146-58. doi: 10.1074/jbc.M114.572172. Epub 2014 Aug 11.


Deletion of the thrombin cleavage domain of osteopontin mediates breast cancer cell adhesion, proteolytic activity, tumorgenicity, and metastasis.

Beausoleil MS, Schulze EB, Goodale D, Postenka CO, Allan AL.

BMC Cancer. 2011 Jan 19;11:25. doi: 10.1186/1471-2407-11-25.


Thrombin-activatable carboxypeptidase B cleavage of osteopontin regulates neutrophil survival and synoviocyte binding in rheumatoid arthritis.

Sharif SA, Du X, Myles T, Song JJ, Price E, Lee DM, Goodman SB, Nagashima M, Morser J, Robinson WH, Leung LL.

Arthritis Rheum. 2009 Oct;60(10):2902-12. doi: 10.1002/art.24814.


Osteopontin is cleaved at multiple sites close to its integrin-binding motifs in milk and is a novel substrate for plasmin and cathepsin D.

Christensen B, Schack L, Kläning E, Sørensen ES.

J Biol Chem. 2010 Mar 12;285(11):7929-37. doi: 10.1074/jbc.M109.075010. Epub 2010 Jan 13.


Inhibitory effects of MLDG-containing heterodimeric disintegrins reveal distinct structural requirements for interaction of the integrin alpha 9beta 1 with VCAM-1, tenascin-C, and osteopontin.

Marcinkiewicz C, Taooka Y, Yokosaki Y, Calvete JJ, Marcinkiewicz MM, Lobb RR, Niewiarowski S, Sheppard D.

J Biol Chem. 2000 Oct 13;275(41):31930-7.


Interaction of osteopontin with neutrophil alpha(4)beta(1) and alpha(9)beta(1) integrins in a rodent model of alcoholic liver disease.

Banerjee A, Lee JH, Ramaiah SK.

Toxicol Appl Pharmacol. 2008 Dec 1;233(2):238-46. doi: 10.1016/j.taap.2008.08.008. Epub 2008 Aug 22.


Osteopontin mediates macrophage chemotaxis via α4 and α9 integrins and survival via the α4 integrin.

Lund SA, Wilson CL, Raines EW, Tang J, Giachelli CM, Scatena M.

J Cell Biochem. 2013 May;114(5):1194-202. doi: 10.1002/jcb.24462.


Osteopontin induces growth of metastatic tumors in a preclinical model of non-small lung cancer.

Shojaei F, Scott N, Kang X, Lappin PB, Fitzgerald AA, Karlicek S, Simmons BH, Wu A, Lee JH, Bergqvist S, Kraynov E.

J Exp Clin Cancer Res. 2012 Mar 23;31:26. doi: 10.1186/1756-9966-31-26.


Distinct structural requirements for binding of the integrins alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 to osteopontin.

Yokosaki Y, Tanaka K, Higashikawa F, Yamashita K, Eboshida A.

Matrix Biol. 2005 Sep;24(6):418-27.


Role of osteopontin in neutrophil function.

Koh A, da Silva AP, Bansal AK, Bansal M, Sun C, Lee H, Glogauer M, Sodek J, Zohar R.

Immunology. 2007 Dec;122(4):466-75. Epub 2007 Aug 3.


Enhanced biological activity of polymeric osteopontin.

Higashikawa F, Eboshida A, Yokosaki Y.

FEBS Lett. 2007 Jun 12;581(14):2697-701. Epub 2007 May 21.


A regulated interaction between alpha5beta1 integrin and osteopontin.

Barry ST, Ludbrook SB, Murrison E, Horgan CM.

Biochem Biophys Res Commun. 2000 Jan 27;267(3):764-9.


Osteopontin upregulation and polymerization by transglutaminase 2 in calcified arteries of Matrix Gla protein-deficient mice.

Kaartinen MT, Murshed M, Karsenty G, McKee MD.

J Histochem Cytochem. 2007 Apr;55(4):375-86. Epub 2006 Dec 22.


Thrombin hydrolysis of human osteopontin is dependent on thrombin anion-binding exosites.

Myles T, Leung LL.

J Biol Chem. 2008 Jun 27;283(26):17789-96. doi: 10.1074/jbc.M708629200. Epub 2008 Apr 14.

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